Volume 4.14 | Apr 10

Mesenchymal Cell News 4.14, April 10, 2012
     In this issue: Publications Industry News | Policy News | Events | Jobs 
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A Stem Cell-Based Approach to Cartilage Repair
This work provides new insights into the control of chondrogenesis that may ultimately lead to a stem cell-based therapy for osteoarthritis. [Science] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

Tissue Engineered Regeneration of Completely Transected Spinal Cord Using Human Mesenchymal Stem Cells
Scientists evaluated attachment, proliferation, osteogenic gene expression, alkaline phosphatase/DNA, protein/DNA and mineralization of human adipose-derived stem cells cultured in vitro on multi-walled carbon nanotubes and graphite compacts with the same dimension. [Biomaterials] Abstract

The Stimulation of Adipose-Derived Stem Cell Differentiation and Mineralization by Ordered Rod-Like Fluorapatite Coatings
The effect of ordered rod-like fluorapatite coatings of metal discs on adipose-derived stem cell’s growth, differentiation and mineralization was studied in vitro and their mineral inductive effects in vivo. [Biomaterials] Abstract

Exposure to Supernatants of Macrophages that Phagocytized Dead Mesenchymal Stem Cells Improves Hypoxic Cardiomyocytes Survival
Investigators aimed to observe the impact of supernatants from macrophages that phagocytized dead mesenchymal stem cells on the survival of hypoxic cardiomyocytes. [Int J Cardiol] Abstract

Vitamin D3-Inducible Mesenchymal Stem Cell-Based Delivery of Conditionally Replicating Adenoviruses Effectively Targets Renal Cell Carcinoma and Inhibits Tumor Growth
Scientists demonstrated the intrinsic tumor homing property of human bone marrow-derived mesenchymal stem cells to specifically localize primary and metastatic renal cell carcinoma tumors after systemic administration in a clinically relevant orthotopic animal model. [Mol Pharm] Abstract

Human Olfactory Mucosa Multipotent Mesenchymal Stromal Cells Promote Survival, Proliferation and Differentiation of Human Hematopoietic Cells
Researchers investigated whether human olfactory mucosa-mesenchymal stromal cells may promote the survival, proliferation and differentiation of human hematopoietic stem cells. [Stem Cells Dev] Abstract

Three-Dimensional In Vitro Tri-Culture Platform to Investigate Effects of Crosstalk between Mesenchymal Stem Cells, Osteoblasts and Adipocytes
Scientists’ results suggest novel emergent phenotypes for mesenchymal stem cells, osteoblasts, and adipocytes in bone marrow that are dependent on and result in part from paracrine interactions with their neighboring cell types. [Tissue Eng Part A] Abstract

Interplay between Local versus Soluble TGF-β and Fibrin Scaffolds: Role of Cells and Impact on Human Mesenchymal Stem Cell Chondrogenesis
Researchers described the influence of cell seeding on TGF-β release and compared the molecular path of human mesenchymal stem cell chondrogenic differentiation under soluble versus local TGF-β supply. [Tissue Eng Part A] Abstract

In Vitro and In Vivo Osteogenesis of Human Mesenchymal Stem Cells Derived from Skin, Bone Marrow and Dental Follicle Tissues
This present study evaluated the human mesenchymal stem cells isolated from skin, bone marrow and dental follicle tissues on their in vitro and in vivo osteogenic potential using demineralized bone matrix and fibrin glue scaffold. [Differentiation] Abstract

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IU Researchers Join National Network Testing Stem Cell Therapies for Cardiovascular Disease
Physician scientists at the Indiana University (IU) School of Medicine have been selected to join the nationwide Cardiovascular Cell Therapy Research Network and will begin a new round of tests of adult stem cell treatments for peripheral artery disease this summer. [Indiana University] Press Release

Arteriocyte Receives FDA Approval to Initiate Compartment Syndrome Trial for Amputation Prevention Focused on Wounded Warriors
Arteriocyte announced approval from the Food and Drug Administration (FDA) to initiate a Phase I clinical trial using its Magellan MAR01TM technology in the treatment of Compartment Syndrome. [Arteriocyte]
Press Release

American CryoStem and Protein Genomics Sign Collaboration to Develop Stem Cell Applications for Wound Healing
American CryoStem Corporation and privately-held Protein Genomics announced a collaborative agreement to develop novel cellular therapies for the wound healing, regenerative and cellular therapy markets. [Reuters] Press Release


National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)


NEW Mesenchymal Stem Cell (MSC) Galway 2012: Basic Biology and Clinical Translation of MSCs
July 2-3, 2012
Galway, Ireland

Visit our events page to see a complete list of events in the mesenchymal cell community.


Scientist – Endothelial Cells (STEMCELL Technologies, Inc.)

Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)

Scientist – Hematology (STEMCELL Technologies, Inc.)

Scientist – hPSC (STEMCELL Technologies, Inc.)

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software, Inc.)

Postdoctoral Position – Molecular Cell Biology (Weizmann Institute of Science) 

Research Associate(s) (Imperial College London) 

PhD Student (University of Liège) 

Postdoctoral Position (GENyO)

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