Volume 4.16 | Apr 24

Mesenchymal Cell News 4.16, April 24, 2012
     In this issue: Publications Industry News | Policy News | Events | Jobs 
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TOP STORY
LIGHT Delivery to Tumors by Mesenchymal Stem Cells Mobilizes an Effective Antitumor Immune Response
Scientists tested whether mesenchymal stem cells engineered to express the immune stimulating factor LIGHT could induce tumor regression. [Cancer Res] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

The Use of Autologous Enriched Bone Marrow MSCs to Enhance Osteoporotic Bone Defect Repair in Long-Term Estrogen Deficient Goats
Investigators demonstrated that bone marrow mesenchymal stem cells (MSCs) harvested from goats with long-term estrogen deficiencies exhibited a lower proliferation rate and decreased osteogenic capacity. [Biomaterials] Abstract

Nanotopography as Modulator of Human Mesenchymal Stem Cell Function
Scientists studied a culture of human mesenchymal stem cells on polydimethylsiloxane substrates with 350 nm grating topography and investigated the focal adhesion composition and dynamics using biochemical and imaging techniques. [Biomaterials] Abstract

Regulation of the Fate of Human Mesenchymal Stem Cells by Mechanical and Stereo-Topographical Cues Provided by Silicon Nanowires
Researchers aimed to delineate the effects of stereotopography and its various relevant physical properties on the fate regulation of human mesenchymal stem cells. [Biomaterials] Abstract

Basal Autophagy Decreased during the Differentiation of Human Adult Mesenchymal Stem Cells
This study expands the knowledge on the control exerted by Bcl-xL on autophagy and illustrates the important role of autophagy in the maintenance and differentiation of adult human mesenchymal stem cells. [Stem Cells Dev] Abstract

The Adult Human Brain Harbors Multipotent Perivascular Mesenchymal Stem Cells
Researchers isolated, purified and characterized a previously unrecognized progenitor population from two different regions in the adult human brain. They showed that these cells co-express markers for mesenchymal stem cells and pericytes in vivo and in vitro. [PLoS One] Abstract | Press Release

The Role of SDF-1-CXCR4/CXCR7 Axis in the Therapeutic Effects of Hypoxia-Preconditioned Mesenchymal Stem Cells for Renal Ischemia/Reperfusion Injury
Investigators evaluated the role of the stromal-derived factor-1 (SDF-1)-CXCR4/CXCR7 pathway in regulating chemotaxis, viability and paracrine actions of hypoxic preconditioned-mesenchymal stem cells in vitro and in vivo. [PLoS One] Abstract

Effects of Endothelial Cells on Proliferation and Survival of Human Mesenchymal Stem Cells and Primary Osteoblasts
Researchers investigated the effect of endothelial cells on proliferation and cell survival of human primary osteoblasts and human mesenchymal stem cells. [J Orthop Res] Abstract

Pre-Culturing Human Adipose Tissue Mesenchymal Stem Cells Under Hypoxia Increases Their Adipogenic and Osteogenic Differentiation Potentials
Human adipose tissue mesenchymal stem-cells from four human donors were cultured in growth medium under either normoxic or hypoxic conditions for seven days and were then transferred to normoxic conditions to study their differentiation potential. [Cell Prolif] Abstract

[New Webinar] Discover How to Reduce Variability in Primary Neuron Cultures with NeuroCult SM

INDUSTRY NEWS
New Research Center Unveiled at Annual Ohio State Conference
The Ohio State University has established a partnership of experts who will work together to discover novel treatments to accelerate wound healing and rehabilitation for patients. [The Ohio State University Wexner Medical Center] Press Release

Stem Cell Initiative Receives Additional $1.5 Million Award

Cal Poly Pomona has received a three year, $1.5 million grant renewal for stem cell education and research from the California Institute for Regenerative Medicine. [Cal Poly Pomona] Press Release
POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW 3rd Tissue Engineering and Regenerative Medicine International Society (TERMIS) World Congress
September 5-8, 2012
Vienna, Austria

Visit our events page to see a complete list of events in the mesenchymal cell community.

JOB OPPORTUNITIES

Scientist – Endothelial Cells (STEMCELL Technologies, Inc.)


Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)

Scientist – hPSC (STEMCELL Technologies, Inc.)

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)


Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software, Inc.)


Postdoctoral Position – Molecular Cell Biology (Weizmann Institute of Science) 


PhD Student (University of Liège) 


Postdoctoral Position (GENyO)

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