Volume 4.18 | May 8

Mesenchymal Cell News 4.18, May 8, 2012
     In this issue: Publications Industry News | Policy News | Events | Jobs 
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TOP STORY
High-Strength Silk Protein Scaffolds for Bone Repair
A combination of surface roughness, porosity, and scaffold stiffness favored human bone marrow-derived mesenchymal stem cell differentiation toward bone-like tissue in vitro based on biochemical and gene expression for bone markers. [Proc Natl Acad Sci USA] Abstract | Press Release

Apply Now: Mammary Stem Cell Training Course (June 2-3 2012) in Vancouver, Canada.
PUBLICATIONS (Ranked by Impact Factor of the Journal)

Inhibition of Kupffer Cell Activity Improves Transplantation of Human Adipose-Derived Stem Cells and Liver Functions
The authors showed that the inhibition of Kupffer cell activity improves stem cell transplantation into liver tissue and corrects some of the liver functions under conditions of liver injury. [Cell Transplant] Abstract

Human Mesenchymal Stem Cells Exploit the Immune Response Mediating Chemokines to Impact the Phenotype of Glioblastoma
Scientists aimed to investigate the interactions of human mesenchymal stem cells and glioblastoma multiforme cells under in vitro conditions. [Cell Transplant] Abstract

IFN-γ-Primed Human Bone Marrow Mesenchymal Stem Cells Induce Tumor Cell Apoptosis In Vitro via Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand
Researchers showed that IFN-γ-primed human mesenchymal stem cells could induce cancer cell apoptosis via tumor necrosis factor-related apoptosis-inducing ligand-mediated pathway. [Int J Biochem Cell Biol] Abstract

High Mesenchymal Stem Cell Seeding Densities in Hyaluronic Acid Hydrogels Produce Engineered Cartilage with Native Tissue Properties
Scientists hypothesized that increasing the mesenchymal stem cell seeding density would decrease the required diffusional distance, and so expedite the development of functional properties. [Acta Biomater] Abstract

Immunomodulatory Effects of Bone Marrow-Derived Mesenchymal Stem Cells in a Swine Hemi-Facial Allotransplantation Model
Researchers investigated whether the infusion of bone marrow-derived mesenchymal stem cells, combined with transient immunosuppressant treatment, could suppress allograft rejection and modulate T-cell regulation in a swine orthotopic hemi-facial composite tissue allotransplantation model. [PLoS One] Full Article

Isolation and Characterization of Novel Murine Epiphysis Derived Mesenchymal Stem Cells
The objective of this study was to find an alternative murine mesenchymal stem cell (MSC) source that could provide sufficient MSCs. [PLoS One] Full Article

Long-Term In Vitro Expansion of Human Adipose-Derived Stem Cells Showed Low Risk of Tumorigenicity
Researchers investigated the effect of long-term in vitro expansion on human adipose-derived stem cells. [J Tissue Eng Regen Med] Abstract

Mesenchymal Progenitor Cells Derived from Traumatized Muscle Enhance Neurite Growth
Researchers aimed to determine whether traumatized muscle-derived mesenchymal progenitor cells exhibit neurotrophic function equivalent to that of bone marrow-derived mesenchymal stem cells. [J Tissue Eng Regen Med] Abstract

Human Mesenchymal Stem Cell-Derived Matrices for Enhanced Osteoregeneration
Scientists hypothesized that given the multistage process of osteogenesis, human mesenchymal stem cells-mediated repair might be maximal at a specific time point of healing. [Sci Transl Med] Abstract

[New Webinar] Discover How to Reduce Variability in Primary Neuron Cultures with NeuroCult SM

INDUSTRY NEWS

Interdisciplinary Stem Cell Institute Gets $10 Million Grant from Starr Foundation
The Miller School of Medicine’s Interdisciplinary Stem Cell Institute (ISCI) announced that it received a $10 million grant from The Starr Foundation. The grant will support ISCI in broadening its preclinical and clinical research on stem cells, and help accelerate its pipeline of translational research and programs for a wide range of debilitating conditions. [University of Miami Miller School of Medicine] Press Release

First Fellowships Awarded in New Canadian Stem Cell and Regenerative Medicine Research Program
The first two postdoctoral research fellowships of a new program to promote stem cell research in Canada were announced by the program’s sponsors, Canada’s Stem Cell Network and Pfizer. [Stem Cell Network] Press Release

StemCell Society Singapore 2012 Symposium

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW Keystone Symposia on Molecular and Cellular Biology: Stem Cell Regulation in Homeostasis and Disease
February 24-March 1, 2013
Banff, Canada

Visit
our events page to see a complete list of events in the mesenchymal cell community.

JOB OPPORTUNITIES

Research Associate – Chemistry (STEMCELL Technologies, Inc.)

Research Associate – Particle Chemistry (STEMCELL Technologies, Inc.)

Research Technologist – Contract Assay Services (STEMCELL Technologies, Inc.)


Scientist – Endothelial Cells (STEMCELL Technologies, Inc.)


Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)


Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software, Inc.)


Postdoctoral Position – Molecular Cell Biology (Weizmann Institute of Science) 


PhD Student (University of Liège) 


Postdoctoral Position (GENyO)


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