Volume 4.21 | May 29

Mesenchymal Cell News 4.21 May 29, 2012
     In this issue: Publications Industry News | Policy News | Events | Jobs 
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TOP STORY
Hepatocyte Growth Factor Mediates Mesenchymal Stem Cell-Induced Recovery in Multiple Sclerosis Models
Scientists demonstrated that conditioned medium from human mesenchymal stem cells reduces functional deficits in mouse MOG35-55-induced experimental autoimmune encephalomyelitis and promotes the development of oligodendrocytes and neurons. [Nat Neurosci] Abstract | Press Release

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PUBLICATIONS (Ranked by impact factor of the journal)

Adipose-Derived Mesenchymal Stromal Cells Induce Immunomodulatory Macrophages which Protect from Experimental Colitis and Sepsis
Scientists investigated the effect of adipose-derived mesenchymal stromal cells on the activation state of macrophages in vitro, and the potential therapeutic effect of these cells in experimental colitis and sepsis. [Gut] Abstract

Cellular Mechanical Properties Reflect the Differentiation Potential of Adipose-Derived Mesenchymal Stem Cells

Elastic and viscoelastic properties of undifferentiated adipose-derived stem cells were tested via atomic force microscopy and correlated with lineage-specific metabolite production. Cell sorting simulations based on these “mechanical biomarkers” indicated they were predictive of differentiation capability and could be used to enrich for tissue-specific cells. [Proc Natl Acad Sci USA] Abstract | Press Release

Infusion of Mesenchymal Stem Cells Ameliorates Hyperglycemia in Type 2 Diabetic Rats: Identification of a Novel Role in Improving Insulin Sensitivity
Investigators induced a diabetic rat model by high-fat diet/streptozotocin (STZ) administration, performed mesenchymal stem cell (MSC) infusion during the early phase or late phase after STZ injection, and then evaluated the therapeutic effects of MSC infusion and explored the possible mechanisms involved. [Diabetes] Abstract

Photoactivation of Bone Marrow Mesenchymal Stromal Cells with Diode Laser: Effects and Mechanisms of Action
Researchers investigated the effects of 635 nm diode laser on mouse mesenchymal stromal cell (MSC) proliferation and examined the underlying cellular and molecular mechanisms, focusing the attention on the effects of laser irradiation on Notch-1 signal activation and membrane ion channel modulation. [J Cell Physiol] Abstract

Efficient Expansion of Mesenchymal Stem Cells from Mouse Bone Marrow under Hypoxic Conditions
Scientists have developed a robust method for isolation and expansion of mouse mesenchymal stem cells by combining low-density culture with hypoxic culture. [J Tissue Eng Regen Med] Abstract

Comparative Cellular and Molecular Analyses of Pooled Bone Marrow Multipotent Mesenchymal Stromal Cells during Continuous Passaging and after Successive Cryopreservation
The objective of this study was to determine if the effect of successive cryopreservation of pooled bone marrow derived multipotent mesenchymal stromal cells during the exponential growth phase could impair their morphology, phenotype, gene expression and differentiation capabilities. [J Cell Biochem] Abstract

Mesenchymal Stem Cells Associated with Porous Chitosan-Gelatin Scaffold: A Potential Strategy for Alveolar Bone Regeneration
Scientists evaluated the effects of a chitosan-gelatin scaffold seeded with bone marrow mesenchymal stem cells in the healing process of tooth sockets in rats. [J Biomed Mater Res A] Abstract

Defining Essential Stem Cell Characteristics in Adipose-Derived Stromal Cells Extracted from Distinct Anatomical Sites
Researchers suggest that, while the cell surface profile of adipose-derived stromal cells (ASCs) does not distinguish them from normal fibroblasts, their differentiation capacity and the expression of genes closely linked to pluripotency clearly define ASCs as multipotent stem cells, regardless of tissue isolation location. [Cell Tissue Res] Abstract

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INDUSTRY NEWS

State Awards Stem Cell Grants to UC Davis Researchers
California’s stem cell agency approved two grants to UC (University of California) Davis Health System researchers for their innovative work in regenerative medicine. [UC Davis Health System] Press Release

California’s Stem Cell Agency Announces International Collaborations and $69 Million in New Research Funding
The California Institute for Regenerative Medicine announced its first ever collaboratively funded research projects with China and the federal government of Australia, a new project with Germany, plus $69 million for research to help develop therapies for 15 diseases in its latest round of funding. [California Institute for Regenerative Medicine] Press Release

Maryland Stem Cell Research Commission Funds 40 New Proposals in FY 2012
The board of directors of the Maryland Technology Development Corporation approved the Commission’s recommendation to fund 40 new proposals with the Maryland Stem Cell Research Fund’s $12.4 million FY 2012 budget. [Maryland Stem Cell Research Fund] Press Release

IntelliCell BioSciences Announces Collaborative Agreement with the University of Florida on Stem Cell and Tissue Repair Research
IntelliCell BioSciences, Inc. announced that it has entered a sponsored research agreement with the Institute for Cell Engineering and Regenerative Medicine at the University of Florida. [PR Newswire] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW 24th International Congress of the Transplantation Society
July 15-19, 2012
Berlin, Germany

Visit our events page to see a complete list of events in the mesenchymal cell community.

JOB OPPORTUNITIES

Research Associate – Chemistry (STEMCELL Technologies, Inc.)

Research Associate – Particle Chemistry (STEMCELL Technologies, Inc.)

Research Technologist – Contract Assay Services (STEMCELL Technologies, Inc.)


Scientist – Endothelial Cells (STEMCELL Technologies, Inc.)


Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)


Scientist – Mesenchymal Cell Research (STEMCELL Technologies, Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)


Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software, Inc.)


Postdoctoral Position – Molecular Cell Biology (Weizmann Institute of Science) 


PhD Student (University of Liège)

Postdoctoral Fellowship – Mesenchymal Stem Cell Biology (University of Connecticut Health Center)


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