Volume 4.22 | Jun 5

Mesenchymal Cell News 4.22 June 5, 2012
     In this issue: Publications Industry News | Policy News | Events | Jobs 
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Primary Mesenchymal Stem and Progenitor Cells from Bone Marrow Lack Expression of CD44
Researchers suggest that bone marrow mesenchymal stem cells (MSCs) physiologically lack expression of CD44, highlighting the natural phenotype of MSCs and open new possibilities to prospectively isolate MSCs from the bone marrow. [J Biol Chem] Abstract | Full Article

Learn more about the new smartphone app for human blood cell frequencies
PUBLICATIONS (Ranked by impact factor of the journal)

Role of Subnano-, Nano- and Submicron-Surface Features on Osteoblast Differentiation of Bone Marrow Mesenchymal Stem Cells
This study systematically controlled titanium surface features from the sub-nano to sub-micron scales and investigated the corresponding effects on stem cell responses, such as integrin activation, cyclins, key transcriptional genes of osteoblast differentiation and osteoblastic phenotype genes. [Biomaterials] Abstract

G-CSF Stimulation of Bone Marrow Mesenchymal Stromal Cells Promotes CD34+ Cell Migration via a Matrix Metalloproteinase-2-Dependent Mechanism

Investigators showed that the granulocyte-colony stimulating factor (G-CSF) receptor is expressed by human bone marrow mesenchymal stromal/stem cells (MSCs) and that G-CSF pre-stimulation of MSCs enhances the in vitro trans-stromal migration of CD34+ cells. [Stem Cells Dev] Abstract

Diverse Effects of Cyclic AMP Variants on Osteogenic and Adipogenic Differentiation of Human Mesenchymal Stromal Cells
Scientists investigated the role of cyclic AMP/protein kinase A signaling in differentiation of human mesenchymal stromal cells. [Tissue Eng Part A] Abstract

Donor Age of Human Platelet Lysate Affects Proliferation and Differentiation of Mesenchymal Stem Cells
Researchers support the notion that aging is associated with systemic feedback mechanisms acting on stem and progenitor cells, and suggest this is also relevant for serum supplements in cell culture: human platelet lysates derived from younger donors facilitate enhanced expansion and more pronounced osteogenic differentiation. [PLoS One] Full Article

Mesenchymal Stem Cells-Derived Interleukin-6 and Vascular Endothelial Growth Factor Promote Breast Cancer Cell Migration
By using a small panel of breast cancer cell lines, researchers analyzed the role of interleukin-6 and vascular endothelial growth factor A in the cross-talk between mesenchymal stem cells and breast cancer cells. [J Cell Biochem] Abstract

Recombinant Human Bone Morphogenetic Protein-2 Released from Polyurethane-Based Scaffolds Promotes Early Osteogenic Differentiation of Human Mesenchymal Stem Cells
Researchers aimed to investigate the pharmacokinetics of recombinant human bone morphogenetic protein-2 (rhBMP-2) from a polyurethane-based porous scaffold and to determine the biological responses of human mesenchymal stem cells to the rhBMP-2 released from those scaffolds. [Biomed Mater]

Amelogenin Enhances the Osteogenic Differentiation of Mesenchymal Stem Cells Derived from Bone Marrow
Scientists examined the effect of recombinant human full-length amelogenin on the osteogenic differentiation of cultured human mesenchymal stem cells. [Cells Tissues Organs] Abstract

Effect of Growth Differentiation Factor 5 on the Proliferation and Tenogenic Differentiation Potential of Human Mesenchymal Stem Cells In Vitro
Researchers investigated cell proliferation and tenogenic differentiation in human mesenchymal stem cells exposed to different concentrations of growth differentiation factor 5. [Cells Tissues Organs] Abstract

View Lectures, Tools, Protocols and Other Resources on the Human Immunology Portal (www.humanimmunologyportal.com)


29 Johns Hopkins Stem Cell Researchers Awarded Funding from the Maryland Stem Cell Research Fund
The Maryland Stem Cell Research Fund awarded 29 of 40 grants to Johns Hopkins researchers for the study of stem cell metabolism and regulation, the creation of new cell models for human diseases such as schizophrenia and Rett syndrome and the development of new potential therapies. [The Johns Hopkins University]
Press Release

Osiris Receives Medicare Reimbursement Codes for Grafix®
Osiris Therapeutics, Inc. announced that it has received transitional passthrough status from the Center for Medicare & Medicaid Services, with C‐Codes being designated for Grafix®. [Osiris Therapeutics, Inc.]
Press Release


White House Petitioned to Make Research Free to Access
More than 17,000 people have signed an online petition urging US President Barack Obama to require all scientific journal articles resulting from US taxpayer-funded research to be made freely available online. [White House, United States] Press Release

Horizon 2020: A €80 Billion Battlefield for Open Access
As negotiations proceed to shape the next installment of Europe’s gargantuan research funding programs, scientists, librarians, and publishers are eagerly awaiting the answer to a critical question: How strong will the new seven-year program, called Horizon 2020, be on Open Access? [European Commission, European Union] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)


NEW American Society for Bone and Mineral Research (ASBMR) 2012 Annual Meeting
October 12-15, 2012
Minneapolis, United States

Visit our events page to see a complete list of events in the mesenchymal cell community.


Research Associate – Chemistry (STEMCELL Technologies, Inc.)

Research Associate – Particle Chemistry (STEMCELL Technologies, Inc.)

Research Technologist – Contract Assay Services (STEMCELL Technologies, Inc.)

Research Technologist – Media Development (STEMCELL Technologies, Inc.)

Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – Mesenchymal Cell Research (STEMCELL Technologies, Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software, Inc.)

Postdoctoral Position – Molecular Cell Biology (Weizmann Institute of Science) 

Postdoctoral Fellowship – Fibrosis and Mesenchymal Cell Plasticity (Northwestern University)

Development Scientist – Cell Therapy (GE Healthcare)

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