Volume 4.27 | Jul 10

Mesenchymal Cell News 4.27 July 10, 2012
     In this issue: Publications Industry News | Policy News | Events | Jobs 
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TOP STORY
Human Mesenchymal Stem Cells Shift CD8+ T Cells Towards a Suppressive Phenotype by Inducing Tolerogenic Monocytes
Researchers demonstrated a new immunomodulation mechanism of action of human mesenchymal stem cells through the modulation of CD8+ cells towards a non-cytotoxic/suppressive phenotype. [J Cell Sci] Abstract

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PUBLICATIONS (Ranked by impact factor of the journal)

Enhanced Function of Pancreatic Islets Co-Encapsulated with ECM Proteins and Mesenchymal Stromal Cells in a Silk Hydrogel
Scientists demonstrated that encapsulation in silk with both mesenchymal stromal cells and extracellular matrix (ECM) proteins enhances islet function and suggest, with further development, may have potential as a suitable platform for islet delivery in vivo. [Biomaterials] Abstract

Mesenchymal Stem/Stromal Cells Induce the Generation of Novel IL-10-Dependent Regulatory Dendritic Cells by SOCS3 Activation
Researchers shed new light on the role of mesenchymal stem/stromal cells (MSCs) in modulating regulatory dendritic cell production and support the clinical application of MSCs to reduce the inflammatory response in numerous disease states. [J Immunol] Abstract

Molecular Basis of Immortalization of Human Mesenchymal Stem Cells by Combination of p53 Knockdown and hTERT Overexpression
Scientists suggest that immortalization of mesenchymal stem cells relates to upregulation of cell cycle regulator and DNA repair genes enabling them to bypass cell crisis and complete mitosis. [Stem Cells Dev] Abstract

Insights into the Role of Focal Adhesion Modulation in Myogenic Differentiation of Human Mesenchymal Stem Cells
Researchers report the establishment of a novel platform to induce myogenic differentiation of human mesenchymal stem cell via focal adhesion (FA) modulation, giving insights into the role of FA on stem cell differentiation. [Stem Cells Dev] Abstract

Synovium-Derived Mesenchymal Stem Cells Encapsulated in a Novel Injectable Gel Can Repair Osteochondral Defects in a Rabbit Model
Investigators developed a novel injectable type I collagen/hyaluronic acid/fibrinogen composite gel that encapsulated synovium-derived mesenchymal stem cells for the repair of damaged articular cartilage. [Tissue Eng Part A] Abstract

BMP-Derived Peptide Promotes Chondrogenic Differentiation of Human Mesenchymal Stem Cells
Researchers investigated whether a short BMP-2-derived peptide stimulates chondrogenesis of human mesenchymal stem cells in the absence of other growth factors. [Tissue Eng Part A] Abstract

Intrahippocampal Transplantation of Mesenchymal Stromal Cells Promotes Neuroplasticity
Investigators examined the effects of intrahippocampal transplantation of allogeneic mesenchymal stromal cells on hippocampal structural plasticity and behavioral functions in rats combined with non-invasive cell tracking by magnetic resonance imaging. [Cytotherapy] Abstract

TRAIL-Engineered Pancreas-Derived Mesenchymal Stem Cells: Characterization and Cytotoxic Effects on Pancreatic Cancer Cells
Researchers characterized pancreas-derived mesenchymal stem cells (MSCs) and investigated the effects of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-engineered MSCs on pancreatic cancer cells under different culture conditions. [Cancer Gene Ther] Abstract

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INDUSTRY NEWS

Medistem Receives Notice of Patent Allowance Covering Fat Stem Cell Therapy of Autoimmune Diseases
Medistem Inc. announced notice of allowance from the United States Patent and Trademark Office for a patent covering the use of fat stem cells, and cells associated with fat stem cells for treatment of diseases related to a dysfunctional immune system. [Marketwire] Press Release

Bacterin International Signs Its Fourth National GPO Contract with the Premier Healthcare Alliance
Bacterin International Holdings, Inc. announced its fourth national GPO (group purchasing organization) contract, a three-year agreement with the Premier healthcare alliance. The agreement provides Bacterin’s full biologic portfolio, including Sports Medicine Allografts and traditional allografts for specially negotiated pricing to the nationwide network of hospitals and medical practices served by Premier. [PR Newswire] Press Release

Stem Cell Society Singapore Symposium 2012: Stem Cell Based Therapy

POLICY NEWS

Death of Evidence Announcement
Science in Canada is under attack. To make the public aware of this, Canadians are organizing a ‘Death of Evidence’ rally to coincide with a large scientific conference taking place in Ottawa. [The Death of Evidence, Canada] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW Cell Culture World Congress USA
November 12-13, 2012
Washington, United States

Visit our events page to see a complete list of events in the mesenchymal cell community.

JOB OPPORTUNITIES
Research Associate – Chemistry (STEMCELL Technologies, Inc.)

Research Associate – Particle Chemistry (STEMCELL Technologies, Inc.)

Research Technologist – Contract Assay Services (STEMCELL Technologies, Inc.)

Research Technologist – Media Development (STEMCELL Technologies, Inc.)

Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – Mesenchymal Cell Research (STEMCELL Technologies, Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Postdoctoral Position – Molecular Cell Biology (Weizmann Institute of Science)

Postdoctoral Fellowship – Fibrosis and Mesenchymal Cell Plasticity (Northwestern University)

Scientist/Senior Scientist – Mesenchymal Stem Cell Research (Advanced Cell Technology, Inc.)


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