Volume 4.28 | Jul 17

Mesenchymal Cell News 4.28 July 17, 2012
     In this issue: Publications Industry News | Policy News | Events | Jobs 
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TOP STORY
Histone Demethylases KDM4B and KDM6B Promote Osteogenic Differentiation of Human MSCs
Scientists showed that the histone demethylases KDM4B and KDM6B play critical roles in osteogenic commitment of mesenchymal stem/stromal cells (MSCs) by removing H3K9me3 and H3K27me3. [Cell Stem Cell] Abstract | Press Release

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PUBLICATIONS (Ranked by impact factor of the journal)

Oct4 and Nanog Directly Regulate Dnmt1 to Maintain Self-Renewal and Undifferentiated State in Mesenchymal Stem Cells
Researchers demonstrated the important roles of Oct4 and Nanog in maintaining mesenchymal stem cell properties. [Mol Cell] Abstract

Lysophosphatidic Acid Induces Migration of Human Lung-Resident Mesenchymal Stem Cells Through the β-Catenin Pathway
Scientists demonstrated that bioactive lipid lysophosphatidic acid (LPA) plays a principal role in the migration of human lung-resident mesenchymal stem cells through a signaling pathway involving LPA1 induced β-catenin activation. [Stem Cells] Abstract

Exogenous Nurr1 Gene Expression in Electrically-Stimulated Human Mesenchymal Stem Cells and the Induction of Neurogenesis
Researchers report that electrical stimulation and exogenous Nurr1 gene expression together may be adequate to induce nerve regeneration using stem cells
. [Biomaterials] Abstract

Reconstruction of Epidural Fat with Engineered Adipose Tissue from Adipose Derived Stem Cells and porous Poly(Lactic-Co-Glycolic) Acid in the Rabbit Dorsal Laminectomy Model
Researchers aimed to restore epidural fat using adipose tissue engineered from adipose derived stem cells in a rabbit dorsal laminectomy model. [Biomaterials] Abstract

Intra-Articular Injection of Mesenchymal Stem Cells Expressing Coagulation Factor Ameliorates Hemophilic Arthropathy in Factor VIII-Deficient Mice
Investigators focused on the use of autologous mesenchymal stem cells expressing coagulation factor for the treatment of coagulation factor VIII-deficiency in mice. [J Thromb Haemost] Abstract

Ultraviolet B Preconditioning Enhances the Hair Growth-Promoting Effects of Adipose-Derived Stem Cells via Generation of Reactive Oxygen Species
Scientists investigated the ability of low-dose ultraviolet B (UVB) radiation to stimulate the survival, migration and tube-forming activity of adipose-derived stem cells (ASCs) in vitro, the ability of UVB preconditioning to enhance the hair growth-promoting capacity of ASCs in vivo, and the mechanism of action for ASC stimulation by UVB. [Stem Cells Dev] Abstract

Neonatal Desensitization Supports Long Term Survival and Functional Integration of Human Embryonic Stem Cell-Derived Mesenchymal Stem Cells in Rat Joint Cartilage without Immunosuppresssion
Scientists investigated whether neonatal desensitization supports relative long-term survival of human embryonic stem cells-derived mesenchymal stem cells and promotes cartilage regeneration. [Stem Cells Dev] Abstract

Effect on Ligament Marker Expression by Direct-Contact Co-Culture of Mesenchymal Stem Cells and Anterior Cruciate Ligament Cells
Researchers examined whether a co-culture of anterior cruciate ligament cells and mesenchymal stem cells has a beneficial effect on ligament regeneration that is not observed when utilizing either cell source independently. [Tissue Eng Part A] Abstract

Sliding Contact Loading Enhances the Tensile Properties of Mesenchymal Stem Cell-Seeded Hydrogels
Researchers showed that short-term sliding contact of mesenchymal stem cell-seeded agarose improved chondrogenic gene expression in a manner dependent on both the axial strain applied and transforming growth factor-β supplementation. [Eur Cell Mater] Abstract | Full Article

Anti-Inflammatory Mesenchymal Stem Cells (MSC2) Attenuate Symptoms of Painful Diabetic Peripheral Neuropathy
Scientists determined the effects of MSC2-based therapies on an inflammation-linked painful diabetic peripheral neuropathy mouse model. [Stem Cells Transl Med] Abstract | Press Release

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INDUSTRY NEWS

TiGenix Enrolls First Patients in Pivotal Phase III Trial with Lead Product Cx601 in Perianal Fistulas
TiGenix announced the enrolment of the first patients in the ADMIRE-CD trial, its pivotal Phase III clinical trial with Cx601 in perianal fistulas in Crohn´s disease patients. Cx601 is an adipose derived allogeneic stem cell therapy. [TiGenix NV] Press Release

Regeneus Validates Therapeutic Benefits of Stem Cell Secretions Platform
Regeneus has completed a successful trial validating the efficacy of the company’s adipose-derived stem cell secretion therapy using a well-established mouse model for rheumatoid arthritis. [Regeneus Ltd]
Press Release

Biomedical Engineering Degree First in Western Canada
The University of Victoria is launching a new undergraduate biomedical engineering degree, the first of its kind west of Ontario. [University of Victoria] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW University of Oxford: Stem Cells – A Pathway Through the Maze
December 5-7, 2012
Oxford, United Kingdom

Visit
our events page to see a complete list of events in the mesenchymal cell community.

JOB OPPORTUNITIES

Quality Control Operations Coordinator (STEMCELL Technologies, Inc.)

Research Associate – Chemistry (STEMCELL Technologies, Inc.)

Research Associate – Particle Chemistry (STEMCELL Technologies, Inc.)

Research Technologist – Contract Assay Services (STEMCELL Technologies, Inc.)

Research Technologist – Media Development (STEMCELL Technologies, Inc.)

Research Technologist – Research and Development (STEMCELL Technologies, Inc.)

Scientific Communications & Publishing Coordinator (STEMCELL Technologies, Inc.)

Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – Mesenchymal Cell Research (STEMCELL Technologies, Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Postdoctoral Position – Molecular Cell Biology (Weizmann Institute of Science)

Postdoctoral Fellowship – Fibrosis and Mesenchymal Cell Plasticity (Northwestern University)

Scientist/Senior Scientist – Mesenchymal Stem Cell Research (Advanced Cell Technology, Inc.)


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