Volume 4.29 | Jul 24

Mesenchymal Cell News 4.29 July 24, 2012
     In this issue: Publications Industry News | Policy News | Events | Jobs 
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TOP STORY
Mesenchymal Stem Cells Shape Microglia Effector Functions through the Release of CX3CL1
Findings demonstrate that mesenchymal stem cells instruct, through the release of CX3CL1, microglia responsiveness to pro-inflammatory signals by modulating constitutive “calming” receptors, typically expressed by “steady-state microglia”, thus switching microglia from a detrimental phenotype to a neuroprotective one. [Stem Cells] Abstract

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PUBLICATIONS (Ranked by impact factor of the journal)

Functional Replication of the Tendon Tissue Microenvironment by a Bioimprinted Substrate and the Support of Tenocytic Differentiation of Mesenchymal Stem Cells
Scientists showed how extracellular biophysical and biochemical features intertwine to form a niche that influences cell fate and demonstrated that such complex information could be conveniently reconstructed with synthetic materials and purified extracellular matrix proteins. [Biomaterials] Abstract

Valsartan Impairs Angiogenesis of Mesenchymal Stem Cells through Akt Pathway
Researchers investigated whether type 1 angiotensin II receptor antagonists can alter the angiogenic activity of bone-marrow mesenchymal stem cells and explored the potential mechanism for such an action. [Int J Cardiol] Abstract

Stroma-Directed Imatinib Therapy Impairs the Tumor-Promoting Effect of Bone Marrow-Derived Mesenchymal Stem Cells in an Orthotopic Transplantation Model of Colon Cancer
Data suggest that blocking of platelet-derived growth factor receptor signaling pathways influences the interaction between bone marrow-derived mesenchymal stem cells and tumor cells in the tumor microenvironment, and inhibits the progressive growth of colon cancer. [Int J Cancer] Abstract

Human Induced Pluripotent Stem Cells Differentiated into Chondrogenic Lineage via Generation of Mesenchymal Progenitor Cells
Researchers demonstrated that human induced pluripotent stem cells can be efficiently differentiated into the chondrogenic lineage in vitro via generation of mesenchymal progenitor cells, using a simplified, multistep culture method. [Stem Cells Dev] Abstract

Indian Hedgehog Gene Transfer Is a Chondrogenic Inducer of Human Mesenchymal Stem Cells
Scientists tested whether gene-delivery of the growth factor indian hedgehog was able to induce chondrogenesis in human primary mesenchymal stem cells, and if it was possible by such an approach to modulate the appearance of chondrogenic hypertrophy in pellet cultures in vitro. [Arthritis Res Ther]
Abstract | Full Article

Amniotic Mesenchymal Stem Cells Enhance Wound Healing in Diabetic NOD/SCID Mice through High Angiogenic and Engraftment Capabilities
Researchers evaluated the therapeutic potential of amniotic mesenchymal stem cells using a diabetic mouse wound model
. [PLoS One] Full Article

Upregulation of p16INK4A Promotes Cellular Senescence of Bone Marrow-Derived Mesenchymal Stem Cells from Systemic Lupus Erythematosus Patients
Investigators demonstrated that mesenchymal stem cells from systemic lupus erythematosus patients were senescent and that p16INK4A plays an essential role in the process by inhibiting extracellular signal regulated kinase 1/2 activation. [Cell Signal] Abstract

Caveolin-1 Regulates Proliferation and Osteogenic Differentiation of Human Mesenchymal Stem Cells
Scientists suggest that caveolin-1 normally acts to regulate the differentiation and renewal of mesenchymal stem cells (MSCs), and increased caveolin-1 expression during MSC osteogenesis likely acts as a negative feedback to stabilize the cell phenotype. [J Cell Biochem] Abstract

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INDUSTRY NEWS

Rheumatoid Arthritis New Major Clinical Target After Mesoblast Obtains Positive Results in Inflammatory Arthritis
Mesoblast Limited announced positive results in a large animal model of rheumatoid arthritis following a single intravenous injection of its proprietary allogeneic immunomodulatory adult mesenchymal precursor cells. [Mesoblast Limited] Press Release

Shire’s Advanced BioHealing Renamed Shire Regenerative Medicine
Shire plc announced that Advanced BioHealing, Inc. has changed its name to Shire Regenerative Medicine, Inc. [Shire plc] Press Release

IntelliCell BioSciences Files Patent Application for a New Research Technique
IntelliCell BioSciences, Inc. announced that it has filed a patent application for a new research technique the Company has developed for regenerative medicine. The provisional patent, titled “Isolation of Stromal Vascular Fraction from Non-Living Adipose Tissue Using Ultrasonic Cavitation” expands the field of cellular therapy, and specifically, research in adipose stromal vascular fraction. [PR Newswire Association LLC] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW The 2nd Midwest Conference on Stem Cell Biology and Therapy
October 5-7, 2012
Rochester, United States

Visit
our events page to see a complete list of events in the mesenchymal cell community.

JOB OPPORTUNITIES

Quality Control Operations Coordinator (STEMCELL Technologies, Inc.)

Research Associate – Chemistry (STEMCELL Technologies, Inc.)

Research Associate – Particle Chemistry (STEMCELL Technologies, Inc.)

Research Technologist – Contract Assay Services (STEMCELL Technologies, Inc.)

Research Technologist – Media Development (STEMCELL Technologies, Inc.)

Research Technologist – Research and Development (STEMCELL Technologies, Inc.)

Scientific Communications & Publishing Coordinator (STEMCELL Technologies, Inc.)

Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – Mesenchymal Cell Research (STEMCELL Technologies, Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Postdoctoral Position – Molecular Cell Biology (Weizmann Institute of Science)

Postdoctoral Fellowship – Fibrosis and Mesenchymal Cell Plasticity (Northwestern University)

Scientist/Senior Scientist – Mesenchymal Stem Cell Research (Advanced Cell Technology, Inc.)


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