Volume 4.30 | Jul 31

Mesenchymal Cell News 4.30 July 31, 2012
     In this issue: Publications Science News | Industry News | Policy News | Events | Jobs 
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TOP STORY
The Role of MicroRNA-146a in the Pathogenesis of the Diabetic Wound-Healing Impairment
Researchers have previously shown that treatment of diabetic murine wounds with mesenchymal stem cells can improve healing, but the mechanisms are not completely defined. They hypothesized that abnormal microRNA-146a (miRNA-146a) expression may contribute to the chronic inflammation. To test this hypothesis, they examined the expression of miRNA-146a and its target genes in diabetic and nondiabetic mice at baseline and after injury. [Diabetes] Abstract

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PUBLICATIONS (Ranked by impact factor of the journal)

Silk Ionomers for Encapsulation and Differentiation of Human MSCs
Researchers studied the response of human bone marrow derived human mesenchymal stem cells (MSCs) encapsulated in silk ionomer hydrogels. [Biomaterials] Abstract

Nuclear FGF2 Isoforms Inhibit Bone Marrow Stromal Cell Mineralization through FGF23/FGFR/MAPK In Vitro
Scientists assessed whether high molecular weight isoforms reduced mineralized bone formation via phosphate-independent effects in bone marrow stromal cells by modulating fibroblast growth factor 23 (FGF23)/FGF receptor (FGFR)/ERK signaling. [J Bone Miner Res] Abstract

Effect of an Adipose Derived Stem Cells and Nerve Growth Factor-Incorporated Hydrogel on Recovery of Erectile Function in a Rat Model of Cavernous Nerve Injury
Researchers investigated the effectiveness of human adipose derived stem cell and nerve growth factor-incorporated hyaluronic acid-based hydrogel application on the cavernous nerve in a rat model of bilateral cavernous nerve crush injury. [Tissue Eng Part A] Abstract

Radial-Flow Bioreactor Enables Uniform Proliferation of Human Mesenchymal Stem Cells throughout Three-Dimensional Scaffold
A radial-flow bioreactor was used to induce three-dimensional expansion of human mesenchymal stem cells on a large scaffold. The effect of this expansion on cellular characteristics was investigated. [Tissue Eng Part C Methods] Abstract

Explant Culture: A Simple, Reproducible, Efficient and Economic Technique for Isolation of Mesenchymal Stromal Cells from Human Adipose Tissue and Lipoaspirate
Investigators demonstrated that adipose tissue-derived stromal cells (ASCs) isolated by explant culture are phenotypically and functionally equivalent to those obtained by enzymatic digestion. Further, the explant-derived ASC share the immune privileged status and immunosuppressive properties implicit to mesenchymal stromal cells, suggesting that they are competent to be tested and applied in allogeneic clinical settings. [J Tissue Eng Regen Med] Abstract

Increased Stem Cell Factor/c-Kit by Hypoxia Promotes Autophagy of Human Placental Chorionic Plate-Derived Mesenchymal Stem Cells via Regulating the Phosphorylation of mTOR
Scientists compared the effect of hypoxia on the self-renewal of bone marrow-derived mesenchymal stem cells (MSCs) and placental chorionic plate-derived MSCs and investigated the regulatory mechanisms of self-renewal in each MSC type during hypoxia. [J Cell Biochem] Abstract

Acidic pH Conditions Mimicking Degenerative Intervertebral Discs Impair the Survival and Biological Behavior of Human Adipose-Derived Mesenchymal Stem Cells
Researchers examined the survival and biological behavior of adipose-derived mesenchymal stem cells under an intervertebral disc-like acidic environment. [Exp Biol Med] Abstract

Mineral Trioxide Aggregate-Enriched Nanocomposite TiO2-Polymeric Powder Coatings Support Human Mesenchymal Cell Attachment and Growth
Researchers found the novel polymer/ceramic nanocomposites that were created with ultrafine powder coating technology were continuous, homogenous and nano-rough coatings that enhanced human mesenchymal cell attachment and growth. [Biomed Mater] Abstract

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SCIENCE NEWS

Adult Stem Cells from Liposuction Used to Create Blood Vessels in the Lab
Adult stem cells derived from fat were turned into smooth muscle cells in the laboratory, and then “seeded” onto a very thin collagen membrane. As the stem cells multiplied, the researchers rolled them into tubes matching the diameter of small blood vessels. In three to four weeks, they grew into usable blood vessels. [Press release from the American Heart Association, Inc. discussing research presented at the American Heart Association’s Basic Cardiovascular Sciences 2012 Scientific Sessions, New Orleans] Press Release

Rheumatoid Arthritis New Major Clinical Target after Mesoblast Obtains Positive Results in Inflammatory Arthritis
Mesoblast Limited announced positive results in a large animal model of rheumatoid arthritis following a single intravenous injection of its proprietary allogeneic immunomodulatory adult mesenchymal precursor cells. [Mesoblast Limited] Press Release

INDUSTRY NEWS

Medical College of Wisconsin Researcher to Study New Treatment for Chronic Pain
The Medical College of Wisconsin received a four-year, $1.1 million grant from the National Institutes of Health’s National Institute of Neurological Disorders and Stroke to study the use of genetically modified adult stem cells to treat neuropathic pain. [Medical College of Wisconsin] Press Release

Stem Cell Agency Commits $150 Million to Develop New Therapies
California’s stem cell agency, the California Institute for Regenerative Medicine approved $150 million in new funding to help move promising stem cell-based therapies from the laboratory research phase to clinical trials in people. [California Institute For Regenerative Medicine] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW 8th World Stem Cell Summit
December 3-5, 2012
West Palm Beach, United States

Visit
our events page to see a complete list of events in the mesenchymal cell community.

JOB OPPORTUNITIES

Quality Control Operations Coordinator (STEMCELL Technologies, Inc.)

Research Associate – Chemistry (STEMCELL Technologies, Inc.)

Research Associate – Particle Chemistry (STEMCELL Technologies, Inc.)

Research Technologist – Contract Assay Services (STEMCELL Technologies, Inc.)

Research Technologist – Media Development (STEMCELL Technologies, Inc.)

Research Technologist – Research and Development (STEMCELL Technologies, Inc.)

Scientific Communications & Publishing Coordinator (STEMCELL Technologies, Inc.)

Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – Mesenchymal Cell Research (STEMCELL Technologies, Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Postdoctoral Position – Molecular Cell Biology (Weizmann Institute of Science)

Scientist/Senior Scientist – Mesenchymal Stem Cell Research (Advanced Cell Technology, Inc.)

Postdoctoral Position – Mesenchymal Progenitors, Lung Development and Repair (Boston University)



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