Volume 4.31 | Aug 7

Mesenchymal Cell News 4.31 August 7, 2012
     In this issue: Publications Industry News | Policy News | Events | Jobs 
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TOP STORY
Human Mesenchymal Stem/Stromal Cells (hMSCs) Cultured as Spheroids Are Self-Activated to Produce Prostaglandin E2 (PEG2) that Directs Stimulated Macrophages into an Anti-Inflammatory Phenotype
Scientists explored the effects of hMSC spheroids on macrophages. Results indicated that hMSCs in three-dimensional-spheroid cultures are self-activated, in part by intracellular stress responses, to produce PGE2 that can change stimulated macrophages from a primarily pro-inflammatory M1 phenotype to a more anti-inflammatory M2 phenotype. [Stem Cells] Abstract

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PUBLICATIONS (Ranked by impact factor of the journal)

Human Serine Protease HTRA1 Positively Regulates Osteogenesis of Human Bone Marrow-Derived Mesenchymal Stem Cells and Mineralization of Differentiating Bone-Forming Cells through the Modulation of Extracellular Matrix Protein
Researchers investigated the role of HTRA1 in mesenchymal stem cell osteogenesis and suggested a potential mechanism through which it controls matrix mineralization by differentiating bone-forming cells. [Stem Cells] Abstract

Snail1 Controls TGF-β Responsiveness and Differentiation of Mesenchymal Stem Cells
Researchers demonstrated a new role for Snail1 in transforming growth factor-β (TGF-β) response and mesenchymal stem cell maintenance. [Oncogene] Abstract

Mesenchymal Stem Cells as a Novel Carrier for Targeted-Delivery of Gene in Cancer Therapy Based on Non-Viral Transfection
Scientists showed the effectiveness of non-viral vectors in transferring the therapeutic gene to mesenchymal stem cells (MSCs) and the feasible of using MSCs as a targeted gene delivery carrier, indicating that MSCs could be a promising tumor target delivery vehicle in cancer gene therapy based on non-viral gene recombination. [Mol Pharm] Abstract

Microvesicles Derived from Human Umbilical Cord Mesenchymal Stem Cells Stimulated by Hypoxia Promote Angiogenesis Both In Vitro and In Vivo
Results indicate that membrane microvesicle releasing is one of the major mechanisms underlying the effectiveness of mesenchymal stem cell therapy by promoting angiogenesis. [Stem Cells Dev] Abstract

Conditioned Mesenchymal Stem Cells Attenuate Progression of Chronic Kidney Disease through Inhibition of Epithelial-to-Mesenchymal Transition and Immune Modulation
Mesenchymal stem cells were cultured in media containing various concentrations of basic fibroblast growth factor, epidermal growth factor and ascorbic acid 2-phosphate to investigate whether hepatocyte growth factor secretion could be increased by the stimulation of these growth factors. [J Cell Mol Med] Abstract

Activation of Toll-Like Receptor 3 (TLR3) Amplifies Mesenchymal Stem Cell Trophic Factors and Enhances Therapeutic Potency
Using the RNA mimetic polyinosinic-polycytidylic acid [poly(I:C)] to engage mesenchymal stem cell (MSC) TLR3, researchers found that poly(I:C), signaling through multiple mitogen-activated protein kinase pathways, induced therapeutically relevant trophic factors such as interleukin-6-type cytokines, stromal-derived factor 1, hepatocyte growth factor, and vascular endothelial growth factor while slightly inhibiting the proliferation and migration potentials of MSCs. [Am J Physiol Cell Physiol] Abstract

Differential Effects of Mixed Lymphocyte Reaction Supernatant on Human Mesenchymal Stromal Cells
In addition to phenotype and proliferation, researchers monitored mesenchymal stromal cell differentiation, gene expression and the support of CD34+ hematopoietic stem and progenitor cells after priming with mixed lymphocyte reaction supernatant. [Exp Hematol] Abstract

Surface-Bound Orientated Jagged-1 Enhances Osteogenic Differentiation of Human Periodontal Ligament-Derived Mesenchymal Stem Cells
Researchers investigated the ability to control differentiation of human periodontal ligament derived mesenchymal stem cells using modified surfaces containing the affinity immobilized Notch ligand, Jagged-1. [J Biomed Mater Res A] Abstract

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INDUSTRY NEWS

CPRIT’s Governing Board Ratifies $114 Million in New Cancer Awards
The Cancer Prevention and Research Institute of Texas (CPRIT) announced funding of more than $114 million to support a variety of cancer-fighting efforts in Texas. [Cancer Prevention Research Institute of Texas] Press Release

BioLife Cell Bank and Intrexon Establish Worldwide Exclusive Collaboration for Spinal Muscular Atrophy (SMA)
BioLife Cell Bank, Inc. and Intrexon Corporation announced the formation of a global exclusive research collaboration. Under the collaboration, BioLife, with its extensive physician network and stem cell experience coupled with Intrexon’s innovative technology, will strive to produce new treatments for SMA. [BioLife Cell Bank, Inc.] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW Epigenetics and Stem Cells 2012
October 16-17, 2012
Cambridge, United Kingdom

Visit
our events page to see a complete list of events in the mesenchymal cell community.

JOB OPPORTUNITIES

Quality Control Operations Coordinator (STEMCELL Technologies, Inc.)

Research Technologist – Media Development (STEMCELL Technologies, Inc.)

Research Technologist – Research and Development (STEMCELL Technologies, Inc.)

Scientific Communications & Publishing Coordinator (STEMCELL Technologies, Inc.)

Scientist – Mesenchymal Cell Research (STEMCELL Technologies, Inc.)

Postdoctoral Position – Molecular Cell Biology (Weizmann Institute of Science)

Postdoctoral Position – Cancer Biology (Georgia Health Science University)

Postdoctoral Position – Mesenchymal Progenitors, Lung Development and Repair (Boston University)


Postdoctoral Position – Lung Stem Cell Research (University of Bern)



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