Volume 4.33 | Aug 21

Mesenchymal Cell News 4.33 August 21, 2012
     In this issue: Publications | ReviewsIndustry News | Policy News | Events | Jobs 
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Mesenchymal Stem Cells Transmigrate Between and Directly Through TNF-α-Activated Endothelial Cells
Systemically administered adult mesenchymal stem cells exhibit the critical ability to extravasate at sites of inflammation. Researchers aimed to characterize the basic cellular processes mediating this extravasation and compare them to those involved in leukocyte transmigration. [Stem Cells] Abstract

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PUBLICATIONS (Ranked by impact factor of the journal)

Viability and Proliferation of Rat MSCs on Adhesion Protein-Modified PET and PU Scaffolds
Rat mesenchymal stromal cells (MSCs) were seeded on either polyethylene terephthalate (PET) or polyurethane (PU) fiber-layered culture plates coated with laminin, collagen I, fibronectin, poly-d-lysine or gelatin. Cell density, proliferation, viability, morphology and mRNA expression were evaluated. [Biomaterials] Abstract

Mesenchymal Stem Cells Overexpressing GCP-2 Improve Heart Function through Enhanced Angiogenic Properties in a Myocardial Infarction Model
Scientists evaluated the angio-vasculogenic properties of human adipose tissue-derived mesenchymal stem cells overexpressing the granulocyte chemotactic protein-2 (GCP-2) and determined possible therapeutic effects in an experimental ischaemic heart model. [Cardiovasc Res] Abstract

RELMα Stimulates Proliferation of Mesenchymal Stem Cells While Maintaining Their Multipotency
Scientists investigated the effect of resistin-like molecule α (RELMα) on progenitor stem cell content in mouse lung. [Stem Cells Dev] Abstract

Paracrine Release from Non-Viral Engineered Adipose-Derived Stem Cells Promotes Endothelial Cell Survival and Migration In Vitro
Researchers developed VEGF-overexpressing adipose-derived stem cells (ADSCs) utilizing poly(β-amino esters) and examined the effects of paracrine release from non-viral modified ADSCs on the angiogenic potential of human umbilical vein endothelial cells in vitro. [Stem Cells Dev] Abstract

Enhanced Cartilage Formation via Three-Dimensional Cell Engineering of Human Adipose-Derived Stem Cells
Scientists developed an effective method for large scale in vitro chondrogenic differentiation, which is the procedure that would be required for clinical applications, and the subsequent in vivo cartilage formation of human adipose-derived stem cells. [Tissue Eng Part A] Abstract

Crosstalk on Cell Behavior in Interactive Cocultures of hMSCs with Various Oral Cell Types
Results showed for the first time that behavior of human bone marrow-derived mesenchymal stem cells (hMSCs) reflected by proliferation and gene expression was governed by interaction with various oral cells in a cell type-discriminative manner. In addition, hMSC coculture restrains apoptosis, such that influences on cell behavior appear as a crosstalk. [Tissue Eng Part A] Abstract

An Activator of the cAMP/PKA/CREB Pathway Promotes Osteogenesis from Human Bone Marrow-Derived Mesenchymal Stem Cells
Researchers identified CW008, a derivative of pyrazole-pyridine, that stimulates osteoblast differentiation of human mesenchymal stem cells and increases bone formation in ovariectomized mice. [J Cell Physiol] Abstract

Human Adipose-Derived Cells Can Serve as a Single-Cell Source for the In Vitro Cultivation of Vascularized Bone Grafts
Researchers explored the potential of human adipose-derived mesenchymal stem cells as a single-cell source for osteogenic and endothelial differentiation and the assembly of bone and vascular compartments within the same scaffold. [J Tissue Eng Regen Med] Abstract

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The Role of Recipient T Cells in Mesenchymal Stem Cell-Based Tissue Regeneration
The authors discuss the current understanding of mesenchymal stem cell-based tissue regeneration, emphasizing the role of the immune microenvironment in bone regeneration. [Int J Biochem Cell Biol] Abstract

Enhancing the MSC Therapeutic Response: Cell Localization and Support for Cartilage Repair
This review examines current strategies for optimizing mesenchymal stem cell (MSC) localization, evaluates their limitations and looks to other technologies to devise a combinatorial strategy for the creation of an MSC seeded composite structure that addresses both the mechanical and biological property requirements for enhanced cartilage repair. [Tissue Eng Part B Rev] Abstract


TiGenix Completes Patient Enrollment in Phase IIa Rheumatoid Arthritis Study
TiGenix announced the completion of patient enrollment in the Company’s Phase IIa study of Cx611, a suspension of expanded allogeneic adult stem cells, in rheumatoid arthritis. [TiGenix] Press Release

Proteonomix Receives FDA Permission to Initiate Company-Sponsored Phase I Clinical Trial with UMK-121 in Patients with End-Stage Liver Disease
Proteonomix, Inc. announced that the U.S. Food and Drug Administration (FDA) has granted permission to the Company to initiate a Phase I clinical trial with its mobilization technology UMK-121. UMK-121 is a patent-pending combination of two FDA-approved drugs designed to mobilize mesenchymal stem cells from the bone marrow to the peripheral circulation. [Business Wire] Press Release


National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)


NEW EMBO | EMBL Symposia 2013: Cardiac Biology – From Development to Regenerative Medicine
June 7-9, 2013
Heidelberg, Germany

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Quality Control Operations Coordinator (STEMCELL Technologies, Inc.)

Research Technologist – Media Development (STEMCELL Technologies, Inc.)

Research Technologist – Research and Development (STEMCELL Technologies, Inc.)

Scientific Communications & Publishing Coordinator (STEMCELL Technologies, Inc.)

Scientist – Mesenchymal Cell Research (STEMCELL Technologies, Inc.)

Postdoctoral Position – Molecular Cell Biology (Weizmann Institute of Science)

Postdoctoral Position – Cancer Biology (Georgia Health Science University)

Postdoctoral Position – Mesenchymal Progenitors, Lung Development and Repair (Boston University)

Postdoctoral Position – Stem Cell/Diabetes Research (Johns Hopkins Medical School)

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