Volume 4.35 | Sep 4

Mesenchymal Cell News 4.35 September 4, 2012
     In this issue: Publications | Reviews | Science News | Industry News | Policy News | Events | Jobs 
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TOP STORY
Intravenous Mesenchymal Stem Cells Prevented Rejection of Allogeneic Corneal Transplants by Aborting the Early Inflammatory Response
Researchers used a mouse model of corneal allo-transplantation and demonstrated that peri-transplant intravenous infusion of human mesenchymal stem/progenitor cells decreased the early surgically induced inflammation and reduced the activation of antigen-presenting cells in the cornea and draining lymph nodes. Subsequently, immune rejection was decreased, and allograft survival was prolonged. [Mol Ther] Abstract

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PUBLICATIONS (Ranked by impact factor of the journal)

The Isolation and Differentiation of Human Adipose-Derived Stem Cells Using Membrane Filtration
Human adipose-derived stem cells (hADSCs) were purified from a suspension of human adipose tissue cells by the conventional culture method and by membrane filtration through polyurethane (PU) foam membranes. Results suggested that the hADSCs with the capability for osteogenic differentiation adhered to the PU membranes. [Biomaterials] Abstract

Functional Vascular Smooth Muscle Cells Derived from Human Induced Pluripotent Stem Cells via Mesenchymal Stem Cell Intermediates
Scientists developed an efficient stage-wise strategy that enabled human induced pluripotent stem cells differentiation into contractile smooth muscle cells through an intermediate population of clonogenic and multipotent mesenchymal stem cells. [Cardiovasc Res] Abstract

Transplantation of Adipose-Derived Stem Cells Is Associated with Neural Differentiation and Functional Improvement in a Rat Model of Intracerebral Hemorrhage
Researchers examined whether transplantation of adipose-derived stem cells induces neural differentiation and improves neural function in a rat intracerebral hemorrhage model. [CNS Neurosci Ther] Abstract

Investigating the Role of FGF18 in the Cultivation and Osteogenic Differentiation of Mesenchymal Stem Cells
Scientists constructed fibroblast growth factor 18 (FGF18) and investigated its effects on rat bone marrow mesenchymal stem cells (rBMSCs). The proliferative effects of FGF18 on rBMSCs were examined using an MTS assay. To validate the osteogenic differentiation effects of FGF18, ALP and mineralization activity were examined as well as osteogenic differentiation-related gene levels. [PLoS One] Full Article

HGF and Direct Mesenchymal Stem Cells Contact Synergize to Inhibit Hepatic Stellate Cells Activation through TLR4/NF-kB Pathway
Apart from the paracrine mechanism by which the anti-fibrotic effects of bone marrow-derived mesenchymal stem cells (BMSCs) inhibit activated hepatic stellate cells (HSCs), the effects of direct interplay and juxtacrine signaling between the two cell types are poorly understood. Researchers explored the underlying mechanisms by which BMSCs modulate the function of activated HSCs. [PLoS One] Full Article

Human Serum Is a Suitable Supplement for the Osteogenic Differentiation of Human Adipose-Derived Stem Cells Seeded on Poly-3-Hydroxibutyrate-co-3-Hydroxyvalerate Scaffolds
Researchers evaluated the osteogenic differentiation process of human adipose-derived stem cells in poly-3-hydroxybutyrate-co-3-hydroxyvalerate scaffolds with osteogenic medium supplemented with pooled allogeneic human serum. [Tissue Eng Part A] Abstract

Modular Polylactic Acid Microparticle-Based Scaffolds Prepared via Microfluidic Emulsion/Solvent Displacement Process: Fabrication, Characterization, and In Vitro Mesenchymal Stem Cells Interaction Study
Investigators reported a novel approach for the design and fabrication of polylactic acid microparticle-based scaffolds with microstructural properties suitable for bone and cartilage regeneration. The biological response of the scaffolds was assessed in vitro by using bone marrow-derived rat mesenchymal stem cells. [J Biomed Mater Res A] Abstract

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REVIEWS

Rationale of Mesenchymal Stem Cell Therapy in Kidney Injury
Authors discuss the possible beneficial effect of mesenchymal stromal cell (MSC) treatment in the light of preclinical and clinical data supporting the regenerative and immunomodulatory potential of MSCs. [Am J Kidney Dis] Abstract

Cell Culture World Congress USA 2012

SCIENCE NEWS
Stem Cell-Powered Implant Set to Revolutionize Orthopedic Surgery
Scientists are working to harness the regenerative power of stem cells to improve orthopedic implant surgery. The team has found a reliable method to encourage bone cell growth around a new type of implant. [University of Glasgow] Press Release
INDUSTRY NEWS

AlloCure Begins Phase II Clinical Trial in Acute Kidney Injury
AlloCure, Inc. announced that it has initiated a phase II clinical trial of AC607, the company’s mesenchymal stem cell therapy, as a potential treatment for acute kidney injury. [AlloCure, Inc.] Press Release

NIH Awards $7.5 Million, Designates URMC Orthopedics as Center of Research Translation
The University of Rochester Medical Center (URMC) was granted a $7.5 million Center of Research Translation award for programs designed to find new therapies for arthritis and bone healing. Scientists will primarily investigate the regulation of stem cells in joint tissue and bone, and how tissues respond after musculoskeletal injury to knees and hips. [University of Rochester Medical Center] Press Release

Anne-Marie Duliege Appointed to Governing Board of California’s Stem Cell Agency
Anne-Marie Duliege, MD, Chief Medical Officer of Affymax Inc., has been appointed to the Independent Citizens Oversight Committee, the governing board of California’s stem cell agency, the California Institute for Regenerative Medicine. [California Institute for Regenerative Medicine] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW Stem Cells 2012
October 10-12, 2012
Mumbai, India

Visit
our events page to see a complete list of events in the mesenchymal cell community.

JOB OPPORTUNITIES

Quality Control Operations Coordinator (STEMCELL Technologies, Inc.)

Research Technologist – Media Development (STEMCELL Technologies, Inc.)

Research Technologist – Research and Development (STEMCELL Technologies, Inc.)

Scientific Communications & Publishing Coordinator (STEMCELL Technologies, Inc.)

Scientist – Mesenchymal Cell Research (STEMCELL Technologies, Inc.)

Postdoctoral Position – Molecular Cell Biology (Weizmann Institute of Science)

Postdoctoral Position – Stem Cell/Diabetes Research (Johns Hopkins Medical School)

Research Associate – Quality Assurance (University of California)

Postdoctoral Position – DNA Repair and Genomic Instability in Mesenchymal Stromal/Stem Cells (University of Rennes 1)


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