Volume 4.39 | Oct 2

Mesenchymal Cell News 4.39 October 2, 2012
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The Inhibition by Interleukin 1 of MSC Chondrogenesis and the Development of Biomechanical Properties in Biomimetic 3D Woven PCL Scaffolds
Scientists hypothesized that a three-dimensionally (3D) woven poly(ε-caprolactone) (PCL) scaffold seeded with bone marrow-derived mesenchymal stem cells (MSCs) would provide biomimetic mechanical properties in early stages of in vitro culture as the MSCs assembled a functional, cartilaginous extracellular matrix. [Biomaterials] Abstract

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PUBLICATIONS (Ranked by impact factor of the journal)

Chemical Modification of Collagen Improves Glycosaminoglycan Retention of Their Co-Precipitates
Chemical modifications, namely deamination, methylation and amination, were used to alter the net charge of collagen prior to fabrication of collagen-glycosaminoglycan co-precipitate. Despite lower initial cell adhesion than untreated, all modified scaffolds promoted proliferation of human mesenchymal stem cells and showed >95% cell viability at all time points. [Acta Biomater] Abstract

Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Alleviate Liver Fibrosis
Researchers found that transplantation of exosomes derived from human umbilical cord mesenchymal stem cells reduced surface fibrous capsules and got their textures soft, as well as alleviated hepatic inflammation and collagen deposition in carbon tetrachloride-induced fibrotic liver. [Stem Cells Dev] Abstract

Isolation and Characterization of CD276+/HLA-E+ Human Sub-Endocardial Mesenchymal Stem Cells from Chronic Heart Failure Patients: Analysis of Differentiative Potential and Immunomodulatory Markers Expression
Investigators showed a novel method to reproducibly isolate and culture mesenchymal stem cells from the sub-endocardial zone of human left ventricle from patients undergoing heart transplant for post-infarct chronic heart failure. [Stem Cell Dev] Abstract

Mesenchymal Stem Cell 1 (MSC1)-Based Therapy Attenuates Tumor Growth Whereas MSC2-Treatment Promotes Tumor Growth and Metastasis
Researchers previously developed a new approach to induce the conventional mixed pool of mesenchymal stem cells (MSCs) into two uniform but distinct phenotypes they termed MSC1 and MSC2. Here they tested the in vitro and in vivo stability of MSC1 and MSC2 phenotypes as well as their effects on tumor growth and spread. [PLoS One] Full Article

Tissue Inhibitor of Matrix Metalloproteinase-3 or Vascular Endothelial Growth Factor Transfection of Aged Human Mesenchymal Stem Cells Enhances Cell Therapy after Myocardial Infarction
Scientists genetically engineered old human mesenchymal stem cells with tissue inhibitor of matrix metalloproteinase-3 and vascular endothelial growth factor and evaluated the effects on the efficacy of cell-based gene therapy in a rat myocardial infarction model. [Rejuvenation Res] Abstract

Retinoic Acid Regulates Commitment of Undifferentiated Mesenchymal Stem Cells into Osteoblasts and Adipocytes
Researchers investigated the role of retinoic acid (RA) in differentiation of mesenchymal stem cells using the C3H10T1/2 cell line. RA stimulated activity and expression of alkaline phosphatase (ALP) and upregulated activity of the ALP gene promoter. [J Bone Miner Metab] Abstract

Maohuoside A Acts in a BMP-Dependent Manner during Osteogenesis
Maohuoside A, a single compound isolated from the Epimedium koreanum Nakai, was found to promote osteogenesis in mouse bone marrow-derived mesenchymal stem cells. [Phytother Res] Abstract

Low-Level Visible Light Irradiation Promotes Proliferation of Mesenchymal Stem Cells
Researchers demonstrated the ability of broadband visible light illumination to promote proliferation of mesenchymal stem cells in vitro. [Lasers Med Sci] Abstract

Human Mesenchymal Precursor Cells (Stro-1+) from Spinal Cord Injury Patients Improve Functional Recovery and Tissue Sparing in an Acute Spinal Cord Injury Rat Model
Investigators aimed to determine the potential of purified human mesenchymal precursor cells to repair the injured spinal cord after transplantation into T-cell deficient athymic RNU nude rats following acute moderate contusive spinal cord injury. [Cell Transplant] Abstract | Full Article

Isolation of Mesenchymal Stem Cells from Shoulder Rotator Cuff: Potential Source for Muscle and Tendon Repair
Similar to bone marrow mesenchymal stem cells, rotator cuff mesenchymal stem cells were proved to have the potential to undergo osteogenic, adipogenic, and chondrogenic differentiation. [Cell Transplant]
Abstract | Full Article

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Medistem and Superview Biotechnology Co. Ltd. Initiate Collaboration on Therapeutics Development Using Antibody and Stem Cell Technology
Medistem Inc announced the initiation of a collaboration with Superview Biotechnology Co. Ltd, a subsidiary of Yinhuan Holding Co from Yixing, China. The joint work will be aimed at using proprietary stem cell lines developed by Medistem for screening of monoclonal antibodies for therapeutic activity in the area of regenerative medicine. [Business Wire] Press Release

Cytori Awarded Contract Valued up to $106 Million by Biomedical Advanced Research and Development Authority to Develop Cell Therapies for Thermal Burns Combined with Radiation Injury
Cytori Therapeutics has been awarded a contract that may be valued up to $106 million by the U.S. Department of Health and Human Service’s Biomedical Advanced Research and Development Authority, if all contract options are executed. The contract is for preclinical and clinical development of the company’s cell therapy for the treatment of thermal burns combined with radiation injury. Cytori’s cell therapy is based on a patient’s own adipose-derived stem and regenerative cells  processed by the Company’s proprietary Celution® System technology. [Cytori Therapeutics]
Press Release

New Edition of Definitive (Two-Volume) Resource in Stem Cells Released
Advanced Cell Technology, Inc. announced that its chief scientific officer, Robert Lanza, M.D. and Anthony Atala, M.D., have released the second edition of Handbook of Stem Cells, the widely-recognized definitive resource in the field of stem cells. [Advanced Cell Technology, Inc.] Press Release

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NEW Novel Therapeutics Targets in Myocardial Infarction
December 14, 2012
New York City, United States

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