Volume 4.42 | Oct 23

Mesenchymal Cell News 4.42 October 23, 2012
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs 
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TOP STORY

Injury-Activated Transforming Growth Factor β Controls Mobilization of Mesenchymal Stem Cells for Tissue Remodeling
Using several animal models in which latent transforming growth factor β (TGFβ) is activated in the vascular matrix in response to injury of arteries, investigators showed that active TGFβ controls the mobilization and recruitment of mesenchymal stem cells to participate in tissue repair and remodeling. [Stem Cells] Abstract

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PUBLICATIONS (Ranked by impact factor of the journal)

Demethylation of Epiregulin Gene by Histone Demethylase FBXL11 and BCL6 Corepressor Inhibits Osteo/Dentinogenic Differentiation
Scientists investigated FBXL11, a lysine-specific 2A histone demethylase, which is evolutionarily conserved, ubiquitously expressed, and a member of the JmjC-domain-containing histone demethylase family. They found that FBXL11 regulated osteo/dentinogenic differentiation in mesenchymal stem cells. [Stem Cells] Abstract

Cardiac Progenitors Derived from Reprogrammed Mesenchymal Stem Cells Contribute to Angiomyogenic Repair of the Infarcted Heart
Researchers reported efficient reprogramming of multipotent bone marrow mesenchymal stem cells (MSCs) to pluripotent status. The resultant MSC derived induced pluripotent stem cells and their derived progenitors effectively repaired the infarcted heart. [Basic Res Cardiol] AbstractFull Article

TNF-α Suppresses the Mesenchymal Stem Cell Osteogenesis Promoter miR-21 in Estrogen Deficiency-Induced Osteoporosis
Investigators identified a novel mechanism that TNF-α suppressing the functional axis of a key microRNA(miR)-21 contributes to estrogen deficiency-induced osteoporosis. miR-21 was significantly down-regulated in mesenchymal stem cells derived from estrogen deficiency-induced osteoporosis. [J Bone Miner Res] Abstract

Control of 3D Substrate Stiffness to Manipulate Mesenchymal Stem Cell Fate toward Neuronal or Glial Lineages
Researchers investigated the change of matrix stiffness on the influence of neurogenic differentiation of human mesenchymal stem cells. [Acta Biomater] Abstract

Juxtacrine and Paracrine Interactions of Rat Marrow Derived Mesenchymal Stem Cells, Muscle Derived Satellite Cells and Neonatal Cardiomyocytes with Endothelial Cells in Angiogenesis Dynamics
Scientists investigated the juxtacrine and paracrine interaction between three different cells, namely rat marrow-derived mesenchymal stem cells, rat muscle-derived satellite cells and rat neonatal cardiomyocytes, and endothelial cells during the angiogenesis process. [Stem Cell Dev] Abstract

MSM Enhances GH Signaling via the Jak2/STAT5b Pathway in Osteoblast-Like Cells and Osteoblast Differentiation through the Activation of STAT5b in MSCs
Researchers investigated the effects of methylsulfonylmethane (MSM) on the growth hormone (GH) signaling via the Janus kinase (Jak)/signal transducers and activators of transcription (STAT) pathway in osteoblasts and the differentiation of primary bone marrow mesenchymal stem cells (MSCs). [PLoS One] Full Article

Combination Treatment of Hypothermia and Mesenchymal Stromal Cells Amplifies Neuroprotection in Primary Rat Neurons Exposed to Hypoxic-Ischemic-Like Injury In Vitro: Role of the Opioid System
Scientists designed a study to reveal the therapeutic regimen and mechanism of action underlying hypothermia treatment in combination with stem cell transplantation for ameliorating neonatal hypoxic-ischemic-like injury. [PLoS One] Full Article

Comparative Analysis of Mesenchymal Stem Cells from Adult Mouse Adipose, Muscle, and Fetal Muscle
Investigators focused on the differences of mesenchymal stem cells from adult adipose, skeletal muscle and fetal muscle in biological characteristics, which is the key to cell therapy success. [Mol Biol Rep]
Abstract | Full Article

In Vitro Chondrogenesis by BMP6 Gene Therapy
The promotion of in vitro chondrogenesis was investigated by using chitosan scaffolds and rat bone marrow-derived mesenchymal stem cells which are transfected by BMP6 (bone morphogenetic protein-6) encoding gene. [J Biomed Mater Res A] Abstract

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REVIEWS

Is CD34 Truly a Negative Marker for Mesenchymal Stromal Cells?
The prevailing school of thought is that mesenchymal stromal cells (MSC) do not express CD34, and this sets MSC apart from hematopoietic stem cells (HSC), which do express CD34. However, the evidence for MSC being CD34 is largely based on cultured MSC, not tissue-resident MSC, and the existence of CD34 HSC is in fact well documented. [Cytotherapy] Abstract

Cell Sources for the Regeneration of Articular Cartilage: The Past, the Horizon and the Future
The author discusses the cell sources which are currently being investigated for the generation of chondrogenic cells. Autologous chondrocyte implantation using chondrocytes expanded ex vivo was the first chondrogenic cellular therapy to be used clinically. Limitations in expansion potential have led to the investigation of adult mesenchymal stem cells as an alternative cell source and these therapies are beginning to enter clinical trials. [Int J Exp Pathol] Abstract

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INDUSTRY NEWS

Association Establishes the AABB Center for Cellular Therapies
AABB (formerly the American Association of Blood Banks) has established the AABB Center for Cellular Therapies, a functional unit within AABB that will focus on activities designed to foster patient safety and responsible innovation in the cellular therapy and regenerative medicine field. [AABB] Press Release

The C4C Consortium Announces the Implementation of France’s First Ever Facility for the Industrialization of Cell Therapeutics and Presents the Five Drugs under Development for Use in Personalized Medicine
The CELLforCURE (C4C) consortium today announced the implementation of France’s first ever dedicated technical facility for the manufacture of cell therapy products. The C4C project brings together two biotech companies and seven public-sector organizations and university medical centers. [Business Wire]
Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW Bone Marrow Therapy Tandem Meetings
February 13-17, 2013
Salt Lake City, United States

Visit
our events page to see a complete list of events in the mesenchymal cell community.

JOB OPPORTUNITIES

Quality Control Operations Coordinator (STEMCELL Technologies, Inc.)

Scientific Communications & Publishing Coordinator (STEMCELL Technologies, Inc.)

Product Manager – Hematopoietic (STEMCELL Technologies, Inc.)

Product Quality Scientist (STEMCELL Technologies, Inc.)


Scientist – Endothelial Cell Research (STEMCELL Technologies, Inc.)

Research Technologist – Cell Separation (STEMCELL Technologies, Inc.)

Research Associate – Quality Assurance (University of California)

Postdoctoral Position – Tumorigenicity of Mesenchymal Stem Cells Department of Molecular Cell Biology (Weizmann institute of Science)

Postdoctoral Position – Stem Cell and Cardiovascular Diseases (Zhejiang University School of Medicine)

Postdoctoral Position – Membrane Biology in Cell Signaling (University of Texas at Houston)

Postdoctoral Position – Tumor Stem Cells (Cancer Institute of New Jersey)

Tenure-Track Assistant Professor – Vertebrate Stem Cell/Regenerative Biology (Harvard Stem Cell Institute)


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