Volume 4.44 | Nov 6

Mesenchymal Cell News 4.44 November 6, 2012
     In this issue: Publications | Reviews | Industry News | Policy News | Events  | Jobs 
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TOP STORY

Comparison of Allogeneic vs Autologous Bone Marrow-Derived Mesenchymal Stem Cells Delivered by Transendocardial Injection in Patients with Ischemic Cardiomyopathy: The POSEIDON Randomized Trial
In this early-stage study of patients with ischemic cardiomyopathy, transendocardial injection of allogeneic and autologous mesenchymal stem cells (MSCs) without a placebo control were both associated with low rates of treatment-emergent serious adverse events, including immunologic reactions. In aggregate, MSC injection favorably affected patient functional capacity, quality of life, and ventricular remodeling. [JAMA]  Full Article | Press Release

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PUBLICATIONS (Ranked by impact factor of the journal)

Exosomes Mediate the Cytoprotective Action of Mesenchymal Stromal Cells on Hypoxia-Induced Pulmonary Hypertension
Scientists fractionated mouse mesenchymal stromal cell-conditioned media to identify the biologically-active component affecting in vivo hypoxic signaling and determined that exosomes suppressed the hypoxic pulmonary influx of macrophages and the induction of pro-inflammatory and pro-proliferative mediators, including monocyte chemoattractant protein-1 and hypoxia-inducible mitogenic factor, in the murine model of hypoxic pulmonary hypertension. [Circulation] Abstract | Press Release

A Therapeutic Strategy for Metastatic Malignant Fibrous Histiocytoma through Mesenchymal Stromal Cell-Mediated TRAIL Production
To overcome the therapeutic limitations of malignant fibrous histiocytoma (MFH), investigators evaluated human adipose tissue-derived mesenchymal stromal cells that secrete tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) on metastatic MFH. [Ann Surg] Abstract

The Use of Type 1 Collagen Scaffold Containing Stromal Cell-Derived Factor-1 to Create a Matrix Environment Conducive to Partial-Thickness Cartilage Defects Repair
Scientists aimed to create an in situ matrix environment conducive to cartilage-derived mesenchymal stem cells and synovial membrane-derived mesenchymal stem cells to promote cartilage self-repair. [Biomaterials] Abstract

Adenoviral Vectors Stimulate Glucagon Transcription in Human Mesenchymal Stem Cells Expressing Pancreatic Transcription Factors
Researchers examined whether a viral vector system itself could impact the differentiation capacity of human bone-marrow derived mesenchymal stem cells toward the endocrine lineage. [PLoS One] Full Article

Close Interactions between Mesenchymal Stem Cells and Neuroblastoma Cell Lines Lead to Tumor Growth Inhibition
Scientists aimed to investigate the role of mesenchymal stem cells in the control of the growth of neuroblastoma, which is the second most common solid tumor in children. [PLoS One] Full Article

Coordinated Time-Dependent Modulation of AMPK/Akt/mTOR Signaling and Autophagy Controls Osteogenic Differentiation of Human Mesenchymal Stem Cells
Scientists investigated the role of adenosine monophosphate-activated protein kinase (AMPK), Akt, mammalian target of rapamycin (mTOR), autophagy and their interplay in osteogenic differentiation of human dental pulp mesenchymal stem cells. [Bone] Abstract

Vitamin MK-7 Enhances Vitamin D3-Induced Osteogenesis in hMSCs: Modulation of Key Effectors in Mineralization and Vascularization
Investigators evaluated the effects of vitamin MK-7, alone or in association with vitamin D3, in differentiating human mesenchymal stem cells (hMSCs) in vitro along the osteoblastic lineage. [J Tissue Eng Regen Med] Abstract

Tissue Engraftment of Hypoxic-Preconditioned Adipose-Derived Stem Cells Improves Flap Viability
Scientists investigated the potential of adipose-derived stem cells (ASCs) to prevent tissue ischemia. They found conditioned media from hypoxic ASCs had increased levels of vascular endothelial growth factor and enhanced endothelial cell tubule formation. [Wound Repair Regen] Abstract

Arsenic Inhibits the Adipogenic Differentiation of Mesenchymal Stem Cells by Down-Regulating Peroxisome Proliferator-Activated Receptor Gamma and CCAAT Enhancer-Binding Proteins
Researchers reported that arsenic inhibits the adipogenic differentiation of human mesenchymal stem cells. Arsenic reduced the formation of lipid droplets and the expression of adipogenesis-related proteins, such as CCAAT enhancer binding protein, peroxisome proliferator-activated receptor- gamma, and adipocyte fatty acid-binding protein aP2. [Toxicol In Vitro] Abstract

The Protective Effect of Adipose-Derived Stem Cells against Liver Injury by Trophic Molecules
Investigators transplanted adipose-derived stem cells into mice after 70% hepatectomy and ischemia-reperfusion, and observed liver injury and regeneration after reperfusion. [J Surg Res] Abstract

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REVIEWS

Biomechanical Regulation of Mesenchymal Cell Function
Although mechanical regulation of cell function and tissue remodeling has long been appreciated in other contexts, the purpose of this review is to highlight the increasing appreciation of its importance in fibrosis and hypertrophic scarring. [Curr Opin Rheumatol] Abstract
INDUSTRY NEWS
Wibi+Works, LLC Awarded $400,000
Wibi+Works, LLC has been awarded a $400,000 Phase I Small Business Innovation Research Grant from the National Institutes of Health. The grant will be used to fund the development of its adult allogeneic mesenchymal stem cell-based therapy for the anti-inflammatory treatment of rheumatoid arthritis. [Wibi+Works, LLC] Press Release

Stem Cell Research at UCSB Soars with New Lab Space and New Research Teams
Campus leaders, dignitaries, scientists, and engineers gathered at UC Santa Barbara (UCSB) to celebrate the completion of a dream: 10,000 square feet of renovated laboratory space devoted to stem cell research. This was the grand opening ceremony and ribbon-cutting in celebration of UCSB’s Center for Stem Cell Biology and Engineering, part of the Neuroscience Research Institute. The California Institute for Regenerative Medicine contributed to the renovation with a $3.2 million grant that was matched by $3.2 million from UCSB. [UC Santa Barbara] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW Cancer Cell Metabolism and Systems Biology
December 6, 2012
New York City, United States


Visit
our events page to see a complete list of events in the mesenchymal cell community.

JOB OPPORTUNITIES

Quality Control Operations Coordinator (STEMCELL Technologies, Inc.)

Product Manager – Hematopoietic (STEMCELL Technologies, Inc.)

Product Quality Scientist (STEMCELL Technologies, Inc.)


Scientist – Endothelial Cell Research (STEMCELL Technologies, Inc.)

Research Technologist – Cell Separation (STEMCELL Technologies, Inc.)

Postdoctoral Position – Tumorigenicity of Mesenchymal Stem Cells Department of Molecular Cell Biology (Weizmann institute of Science)

Postdoctoral Position – Stem Cell and Cardiovascular Diseases (Zhejiang University School of Medicine)

Postdoctoral Position – Tumor Stem Cells (Cancer Institute of New Jersey)

Experienced Researcher (Hebrew University of Jerusalem)


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