Volume 4.46 | Nov 20

Mesenchymal Cell News 4.46 November 20, 2012
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs 
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CCR2-Dependent Recruitment of Macrophages by Tumor-Educated Mesenchymal Stromal Cells Promotes Tumor Development and Is Mimicked by TNFα
Tumor-resident mesenchymal stromal cells (MSCs) are known to affect tumor growth, but the mechanisms are largely unknown. Scientists found that MSCs isolated from spontaneous lymphomas in mice strikingly enhanced tumor growth in comparison to bone marrow MSCs. [Cell Stem Cell] Abstract | Graphical Abstract

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PUBLICATIONS (Ranked by impact factor of the journal)

Targeting Androgen Receptor in Bone Marrow Mesenchymal Stem Cells Leads to Better Transplantation Therapy Efficacy in Liver Cirrhosis
Using two liver cirrhosis mouse models induced by CCl4 or TAA, the authors showed targeting androgen receptor in the bone marrow mesenchymal stem cells improves their self-renewal and migration potentials and increases paracrine effects to exert anti-inflammatory and anti-fibrotic actions to enhance liver repair. [Hepatology] Abstract

Isolation of Mouse Mesenchymal Stem Cells on the Basis of Expression of Sca-1 and PDGFR-α
Scientists described in detail their protocol to isolate platelet-derived growth factor receptor α (PDGFR-α)-positive and stem cell antigen 1 (Sca-1)-positive mesenchymal stem cells using flow cytometry. [Nat Protoc] Abstract

The Impact of Cell Source, Culture Methodology, Culture Location and Individual Donors on Gene Expression Profiles of Bone Marrow-Derived and Adipose-Derived Stromal Cells
Bone marrow stromal cells were collected from either human bone marrow or adipose tissue, and expanded using two different culture methods: one based on fetal calf serum, and one based on human platelet lysate. [Stem Cell Dev] Abstract

Prospective Dual Role of Mesenchymal Stem Cells in Breast Tumor Microenvironment
The interplay between the breast resident adipose tissue-derived mesenchymal stem cells (B-ASCs) and breast tumor microenvironment was studied. It was found that a distinct subset of B-ASCs display a strong affinity for conditioned media from two breast cancer cell lines, MDA-MB 231 and MCF-7. [Breast Cancer Res Treat] Abstract

Pericyte-Like Progenitors Show High Immaturity and Engraftment Potential as Compared with Mesenchymal Stem Cells
Mesenchymal stem cells (MSCs) and pericyte progenitors (PPs) are both perivascular cells with similar multipotential properties regardless of tissue of origin. Researchers compared the phenotype and function of the two cell types derived from the same bone-marrow samples but expanded in their respective media – pericyte conditions (endothelial cell growth medium 2) for PPs and standard medium (mesenchymal stem cell medium) for MSCs. [PLoS One] Full Article

Differential Gene Expression Profile Associated with the Abnormality of Bone Marrow Mesenchymal Stem Cells in Aplastic Anemia
Scientists comprehensively compared the biological features and gene expression profile of bone marrow mesenchymal stem cells between aplastic anemia patients and healthy volunteers. [PLoS One] Full Article

Activation of Canonical Wnt Pathway Promotes Differentiation of Mouse Bone Marrow-Derived MSCs into Type II Alveolar Epithelial Cells, Confers Resistance to Oxidative Stress, and Promotes their Migration to Injured Lung Tissue In Vitro
The authors investigated the role of the canonical wnt pathway in the differentiation of mouse bone marrow-derived mesenchymal stem cells (MSCs) into type II alveolar epithelial cells. [J Cell Physiol] Abstract

Effects of Transplanted Bone-Marrow-Derived Mesenchymal Stem Cells in Animal Models of Acute Hepatitis
Researchers aimed to evaluate the therapeutic effects of bone-marrow-derived mesenchymal stem cells on ConA-induced hepatitis and to elucidate the possible mechanism involved. [Cell Tissue Res] Abstract

Dissecting the Impact of Frizzled Receptors in Wnt/β-Catenin Signaling of Human Mesenchymal Stem Cells
For studying the functional relevance of Frizzled receptors in Wnt/β-catenin signaling, RNA interference, ectopic expression studies, and rescue approaches were performed in human mesenchymal stem cells carrying a highly sensitive TCF/LEF reporter gene system (Gaussia luciferase). [Biol Chem] Abstract

Long Term Effects of the Implantation of Wharton’s Jelly-Derived Mesenchymal Stem Cells from the Umbilical Cord for Newly-Onset Type 1 Diabetes Mellitus
Researchers assessed the long-term effects of the implantation of Wharton’s jelly-derived mesenchymal stem cells from the umbilical cord for newly-onset Type 1 Diabetes Mellitus. [Endocr J] Abstract | Full Article

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Genetically Engineered Stem Cell Therapy Targeting Angiogenesis and Tumor Stroma in Gastrointestinal Malignancy
The authors summarize the advances made in the past decade towards developing novel cell-based cancer therapies using genetically engineered mesenchymal stem cells with a focus on strategies to achieve and enhance tumor specificity and their application to targeting gastrointestinal malignancies such as hepatocellular carcinoma and pancreatic adenocarcinoma. [Stem Cells] Abstract

Mesenchymal Stromal Cells Improve Survival during Sepsis in the Absence of Heme Oxygenase-1: The Importance of Neutrophils
Researchers investigated the potential use of mesenchymal stromal cells, harvested from compact bone, and their interactions with the innate immune system, during polymicrobial sepsis induced by cecal ligation and puncture. [Stem Cells] Abstract


Stem Cell Clinical Trials to Tackle Diabetes
NUI Galway has been awarded a major new €6 million European project, designed to address complications associated with diabetes. The research project will examine the ability of stem cells to safely control glucose levels and alleviate the damage caused by six different diabetic complications. [NUI Galway] Press Release

Ontario Genomics Institute Invests in Stem Cell Technology at Tissue Regeneration Therapeutics
The Ontario Genomics Institute has invested in Toronto-based Tissue Regeneration Therapeutics (TRT), a company that aims to use umbilical mesenchymal stem cells to treat a variety of serious medical conditions. TRT will use this investment to conduct studies required to apply for approval to initiate human clinical trials. [Ontario Genomics Institute] Press Release


National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)


NEW 39th Annual Meeting of the European Group for Blood and Marrow Transplantation
April 7-10, 2013
London, United Kingdom

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Product Quality Scientist (STEMCELL Technologies, Inc.)

Scientist – Endothelial Cell Research (STEMCELL Technologies, Inc.)

Research Technologist – Cell Separation (STEMCELL Technologies, Inc.)

Scientist or Engineer – hPSC Bioengineer (STEMCELL Technologies, Inc.)

Quality Control Analyst (STEMCELL Technologies, Inc.)

Postdoctoral Position – Tumorigenicity of Mesenchymal Stem Cells Department of Molecular Cell Biology (Weizmann institute of Science)

Postdoctoral Position – Stem Cell and Cardiovascular Diseases (Zhejiang University School of Medicine)

Postdoctoral Position – Tumor Stem Cells (Cancer Institute of New Jersey)

Experienced Researcher (Hebrew University of Jerusalem)

Postdoctoral Position – Stem Cell Research (University of Regensburg)

Postdoctoral Position – Telomere Shortening and MSCs in Myelodysplastic Syndromes (Universita’ degli Studi di Torino)

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