Volume 5.00 | Jan 8

Mesenchymal Cell News 5.00 January 8, 2013
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs 
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TOP STORY
S-Nitrosoglutathione Reductase (GSNOR) Enhances Vasculogenesis by Mesenchymal Stem Cells
Scientists tested the role of nitric oxide signaling in mesenchymal stem cells derived from WT mice and mice homozygous for a deletion of GSNOR, a denitrosylase that regulates S-nitrosylation. [Proc Natl Acad Sci USA] Abstract

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PUBLICATIONS (Ranked by impact factor of the journal)

Direct GSK-3β Inhibition Enhances Mesenchymal Stromal Cell Migration by Increasing Expression of Phospho-β-PAK-Interacting Exchange Factor and CXC Chemokine Receptor 4
Investigators assessed whether inhibition of glycogen synthase kinase-3β (GSK-3β) increases the migration capacity of mesenchymal stromal cells during ex vivo expansion. [Mol Neurobiol]
Full Article

Mesenchymal Stem Cells Prevent Hydrocephalus after Severe Intraventricular Hemorrhage
Researchers determined whether intraventricular transplantation of human umbilical cord blood-derived mesenchymal stem cells prevents posthemorrhagic hydrocephalus development and attenuates brain damage after severe intraventricular hemorrhage in newborn rats. [Stroke] Abstract

Aging Bone Marrow Mesenchymal Stromal Cells Have Altered Membrane Glycerophospholipid Composition and Functionality
The clinical use of human mesenchymal stem/stromal cells (MSCs) demands sequential cell expansions and since it is well established that membrane glycerophospholipids (GPLs) provide precursors for signaling lipids that modulate cellular functions, the authors studied the effect of the donor’s age and cell doublings on the GPL profile of human bone marrow MSC. [J Lipid Res] Abstract

Human Mesenchymal Stem Cells Isolated from Olfactory Biopsies but Not Bone Enhance CNS Myelination In Vitro
Scientists characterized, purified, and assessed the repair potential of human lamina propria mesenchymal-like stem cells by investigating their effect on glial cell biology with specific emphasis on CNS myelination in vitro. [Glia] Abstract

PEP-1-CAT-Transduced Mesenchymal Stem Cells Acquire an Enhanced Viability and Promote Ischemia-Induced Angiogenesis
Poor survival of mesenchymal stem cells (MSC) compromised the efficacy of stem cell therapy for ischemic diseases. Researchers investigated the role of PEP-1-CAT transduction in MSC survival and its effect on ischemia-induced angiogenesis. [PLoS One] Full Article

Functional Comparison of Chronological and In Vitro Aging: Differential Role of the Cytoskeleton and Mitochondria in Mesenchymal Stromal Cells
The authors aimed to determine to which degree in vitro aging and chronological aging may be similar processes or if in vitro culture-related changes at the cellular and molecular level are at least altered as a function of donor age. [PLoS One] Full Article

Mesenchymal Stem Cells as an Appropriate Feeder Layer for Prolonged In Vitro Culture of Human Induced Pluripotent Stem Cells
Because of some problems in the use of animal feeders and in order to simplify the therapeutic application of human induced pluripotent stem cells, investigators tested human adult bone marrow mesenchymal stem cells as a potent feeder system. [Mol Biol Rep] Full Article

Effects of Glucocorticoid Receptor Antagonist, RU486, on the Proliferative and Differentiation Capabilities of Bone Marrow Mesenchymal Stromal Cells in Ovariectomized Rats
Researchers investigated the effects mediated by endogenous glucocorticoids and the effects of an antagonist of the glucocorticoid receptor, RU486, on the proliferative and differentiation capabilities of mesenchymal stem/stromal cells using an ovariectomized animal model. [J Orthop Res] Abstract

A Comparison of Allogeneic and Autologous Mesenchymal Stromal Cells and Osteoprogenitor Cells in Augmenting Bone Formation around Massive Bone Tumor Prostheses
The authors investigated the hypothesis that allogeneic mesenchymal stromal cells and osteoprogenitor cells will augment bone growth equally when compared with autologous bone marrow stem cells. [J Biomed Mater Res A] Abstract

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REVIEWS

Bone Marrow Mesenchymal Stem Cells: Fat On and Blast Off by FGF21
The author highlights recent advances in the understanding of bone marrow mesenchymal stem cells (BMMSC) function and regulation, including the interaction between BMMSCs with the hematopoietic/immune system, and the identification of novel modulators of BMMSC differentiation such as the metabolic hormone fibroblast growth factor 21 (FGF21). [Int J Biochem Cell Biol] Abstract

REGEN 2013 - Clinical Trials & Reimbursement
INDUSTRY NEWS

Soft Tissue Regeneration Receives FDA Clearance to Market Breakthrough Rotator Cuff Repair Device
Soft Tissue Regeneration announced that it has received FDA clearance to market its STR GRAFT, a biodegradable scaffold used for soft tissue augmentation and rotator cuff repair. Developed by Cato T. Laurencin, the STR GRAFT is a three-dimensional braided engineered matrix that Laurencin likens to a patch. [PR Newswire Association LLC] Press Release

Sanford-Burnham Medical Research Institute and Intrexon Corporation Establish Collaboration to Accelerate Stem Cell Research
Sanford-Burnham Medical Research Institute and Intrexon Corporation announced a new collaboration to accelerate stem cell research. Under the agreement, Sanford-Burnham will gain access to sophisticated proprietary cellular selection and gene regulation technologies that are not currently on the market, including Intrexon’s Laser-Enabled Analysis and Processing instrument and RheoSwitch Therapeutic System®. [Intrexon Corporation] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW REGEN 2013 – Clinical Trials & Reimbursement
March 19-21, 2013
Boston, United States


NEW
World Stem Cells & Regenerative Medicine Congress 2013
May 21-23, 2013
London, United Kingdom

Visit
our events page to see a complete list of events in the mesenchymal cell community.

JOB OPPORTUNITIES

Scientist or Engineer – hPSC Bioengineer (STEMCELL Technologies, Inc.)

MSc – Future Opportunities (STEMCELL Technologies, Inc.)

PhD – Future Opportunities (STEMCELL Technologies, Inc.) 

Postdoctoral Position – Tumorigenicity of Mesenchymal Stem Cells (Weizmann Institute of Science)

PhD Student – Stem Cells in Tooth Regeneration (King’s College London)

Postdoctoral Position – Macrophage and Mesenchymal Stem Cell Interactions for Tissue Regeneration (Kent State University)

PhD Studentship – Towards a Steering of Inflammatory Processes in Bone Regeneration (Charite – Universitatsmedizin Berlin)


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