Volume 5.07 | Feb 26

Mesenchymal Cell News 5.07 February 26, 2013
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs 
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CXCL12 in Early Mesenchymal Progenitors Is Required for Hematopoietic Stem-Cell Maintenance
Scientists selectively deleted Cxcl12 from candidate niche stromal cell populations and characterized the effect on hematopoietic progenitor cells. Deletion of Cxcl12 from mineralizing osteoblasts had no effect on hematopoietic stem cells or lymphoid progenitors. [Nature] Abstract | Press Release

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PUBLICATIONS (Ranked by impact factor of the journal)

Cotransplantation with Specific Populations of Spina Bifida Bone Marrow Stem/Progenitor Cells Enhances Urinary Bladder Regeneration
Researchers demonstrated the role of two specific populations of bone marrow stem/progenitor cells used in combination with a synthetic elastomeric scaffold that provides a unique and alternative means to current bladder regeneration approaches. [Proc Natl Acad Sci USA] Abstract | Press Release

Metabolic Rescue of Obese Adipose-Derived Stems Cells by Lin28/Let7 Pathway
The authors evaluated whether adipose-derived stem cells (ASCs) isolated from non-obese and obese tissue differed in their metabolic characteristics and differentiation potential. During differentiation to mature adipocytes, both mouse and human ASCs derived from non-obese tissues increased their insulin sensitivity and inhibition of lipolysis while obese-derived ASCs were insulin-resistant, showing impaired insulin-stimulated glucose uptake and resistance to the antilipolytic effect of insulin. [Diabetes] Abstract

Topical Administration of Allogeneic Mesenchymal Stem Cells Seeded in a Collagen Scaffold Augments Wound Healing and Increases Angiogenesis in the Diabetic Rabbit Ulcer
Investigators hypothesized that topically applied allogeneic mesenchymal stromal cells (MSCs) would improve wound healing by augmenting angiogenesis. Allogeneic non-diabetic bone-marrow derived MSCs were seeded in a collagen scaffold. The cells were applied to a full thickness cutaneous wound in the alloxan-induced diabetic rabbit ear ulcer model in a dose escalation fashion. [Diabetes] Abstract

Delivery of Soluble TRAIL Variants by MSCs in Combination with Cytotoxic Drug Treatment Leads to p53-Independent Enhanced Antitumor Effects
The authors engineered murine mesenchymal stem cells (MSCs) to express a secreted form of the TNF-related apoptosis-inducing ligand (TRAIL), which is a potent inducer of apoptosis in tumor cells, and tested these MSCs. [Cell Death Dis] Abstract

The Effects of Hedgehog on the RNA-Binding Protein Msi1 in the Proliferation and Apoptosis of Mesenchymal Stem Cells
Researchers evaluated the direct effects of Hedgehog (Hh) signaling on the proliferation and apoptosis of human umbilical cord blood-derived mesenchymal stem cells as well as investigated potential downstream regulatory mechanisms that may be responsible for Hh signaling. [PLoS One] Full Article

In Vitro Characterization of Multipotent Mesenchymal Stromal Cells Isolated from Palatal Subepithelial Tissue Grafts
Investigators analyzed whether the mesenchymal stromal cells (MSCs) isolated from palatal tissue grafts harvested in order to cover gingival recessions have the basic characteristics of stem cells. [Microsc Microanal] Abstract

Retrovirus-Mediated Transduction of a Cytosine Deaminase Gene Preserves the Stemness of Mesenchymal Stem Cells
Scientists assessed whether transduction with a retroviral vector encoding cytosine deaminase gene altered the stem cell property of mesenchymal stem cells (MSCs). MSCs were transduced at passage 1 and cultivated up to passage 11. They found that proliferation and differentiation potentials, chromosomal stability and surface antigenicity of MSCs were not altered by retroviral transduction. [Exp Mol Med]
Full Article

The Effect of ATM Kinase Inhibition on the Initial Response of HUMAN Dental Pulp and Periodontal Ligament Mesenchymal Stem Cells to Ionizing Radiation
Researchers evaluated early changes in human mesenchymal stem cells isolated from dental pulp and periodontal ligament after γ-irradiation and the effect of ATM inhibition. [Int J Radiat Biol] Abstract

Cryopreservation of Alginate Encapsulated Mesenchymal Stromal Cells
The authors investigated the response of mesenchymal stromal cells encapsulated in alginate microspheres to different cryopreservation protocols. [Cryobiology] Abstract

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Mesenchymal Stem Cells: A Promising Therapy for the Acute Respiratory Distress Syndrome
Preclinical models of Acute respiratory distress syndrome have demonstrated that intratracheal or systemic administration of mesenchymal stem cells (MSCs) protects the lung against injury. The mechanisms responsible for the protective effects are multiple, including the secretion of multiple paracrine factors capable of modulating the immune response and restoring epithelial and endothelial integrity. [Respiration] Abstract

Osiris Therapeutics Receives Title of European Orphan Drug Designation for Prochymal®
Osiris Therapeutics, Inc. announced that the European Medicines Agency has designated Osiris as the Orphan Drug title holder for Prochymal® (remestemcel-L). The EU Commission adopted the decision to transfer the designation of Prochymal (ex-vivo cultured adult human mesenchymal stem cells) as an orphan medicinal product under Regulation No 141/2000 of the European Parliament and of the Council. [Osiris Therapeutics, Inc.] Press Release

FDA Agreement on Mesoblast’s Use of Singapore Manufacturing Facility for Clinical Trial Production of Proprietary Mesenchymal Precursor Cells
Mesoblast Limited announced that United States Food and Drug Administration (FDA) is in agreement for Mesoblast to supply its proprietary Mesenchymal Precursor Cells for clinical trials in the United States under Investigational New Drug protocols, from Lonza’s contract manufacturing facility in Singapore, in addition to its United States facility. [Mesoblast Limited] Press Release


Expanding Public Access to the Results of Federally Funded Research
In a policy memorandum, Office of Science and Technology Policy Director John Holdren has directed Federal agencies with more than $100 million in R&D expenditures to develop plans to make the published results of federally funded research freely available to the public within one year of publication and requiring researchers to better account for and manage the digital data resulting from federally funded scientific research. [Office of Science and Technology Policy, The White House, United States] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)


NEW SMi’s Cell Culture 2013
July 3-4, 2013
London, United Kingdom

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Postdoctoral Position – Tumorigenicity of Mesenchymal Stem Cells (Weizmann Institute of Science)

Postdoctoral Position – Stem Cell Biology (Johns Hopkins School of Medicine)

Postdoctoral Position – Myeloproliferative Neoplasms (Mount Sinai Medical Center)

Postdoctoral Position – Mesenchymal Stem/Stromal Cells in Acute Myeloid Leukemia (University of Bergen)

Postdoctoral Position – Cancer and Stem Cell Biology (University of Texas at Houston)

Faculty Position – Stem Cell Biology (SARITE Center for Stem Cell Engineering Translational Medicine)

Full Professorship – Stem Cell Biology (Helmholtz Zentrum Munchen)

Postdoctoral Position – Dysregulation of Hematopoietic and Mesenchymal Stem Cells (Indiana University)

Postdoctoral Fellowship (University of Bergen)

Lecturer or Reader – Associate Professor (University of Reading)

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