Volume 5.09 | Mar 12

A Diels-Alder Modulated Approach to Control and Sustain the Release of Dexamethasone and Induce Osteogenic Differentiation of Human Mesenchymal Stem Cells
Researchers report a new approach to controlled drug release based upon exploiting the dynamic equilibrium that exists between Diels-Alder reactants and products, demonstrating the release of a furan containing dexamethasone peptide from a maleimide containing hydrogel. Using a reaction-diffusion model, the release kinetics were tuned to achieve sustained concentrations conducive to osteogenic differentiation of human mesenchymal stem cells. [Biomaterials] Abstract

Allogeneic Mesenchymal Stem Cell Therapy for Bisphosphonate-Related Jaw Osteonecrosis in Swine
To investigate the pathogenesis of bisphosphonates-related osteonecrosis of the jaw (BRONJ) and observe the treatment effect of bone marrow mesenchymal stem cell transplantation, the authors established a pre-clinical animal model of BRONJ in miniature pigs. [Stem Cell Dev] Abstract

Hepatocyte Growth Factor Gene-Modified Mesenchymal Stem Cells Reduce Radiation-Induced Lung Injury
Scientists conducted mesenchymal stem cell-based hepatocyte growth factor gene therapy for radiation-induced lung injury. [Hum Gene Ther] Abstract

Stromal Cell-Derived Factor-1β Mediates Cell Survival through Enhancing Autophagy in Bone Marrow-Derived Mesenchymal Stem Cells
The authors tested the hypothesis that stromal cell-derived factor-1 can mediate cell survival of bone marrow-derived mesenchymal stem/stromal cells in vitro through increasing autophagy. [PLoS One]
Full Article | Press Release

Snail Mediates PDGF-BB-Induced Invasion of Rat Bone Marrow Mesenchymal Stem Cells in 3-D Collagen and Chick Chorioallantoic Membrane
Researchers report that PDGF-BB upregulates both mRNA and protein expression of snail in rat bone marrow mesenchymal stem cells (rBMMSCs). PDGF-BB enhances rBMMSC invasion in three-dimensional (3D) collagen, which is blocked by snail specific siRNA transfection. [J Cell Physiol] Abstract

Expression Profiles of Subtracted mRNAs during Cellular Senescence in Human Mesenchymal Stem Cells Derived from Bone Marrow
Suppression subtractive hybridization was used to identify genes that were differentially expressed between young human mesenchymal stem cells and senescent human mesenchymal stem cells. Scientists selected positive clones that were functionally characterized by referring to public databases using NCBI BLAST tool. [Exp Gerontol] Abstract

Ischemic Brain Injury: A Consortium Analysis of Key Factors Involved in Mesenchymal Stem Cell-Mediated Inflammatory Reduction
Modulation by mesenchymal stem cells in this in vivo and in vitro study shows they decrease markers of microglial activation and astrogliosis following transplantation in an ouabain-induced brain ischemia rat model and in organotypic hippocampal cultures. [Arch Biochem Biophys] Abstract

Nano-Sized Collagen I Molecules Enhanced the Differentiation of Rat Mesenchymal Stem Cells into Cardiomyocytes
Researchers investigated the ability of nano-sized collagen I molecules and a 5-azacytidine treatment to enhance the differentiation of rat mesenchymal stem cells toward a cardiomyogenic phenotype in vitro. [J Biomed Mater Res A] Abstract

Differential Effects of Mesenchymal Stem Cells on a Heterogeneous Cell Population within Lung Cancer Cell Lines
Because malignant tumors contain a heterogeneous cell population with variable capacity for self-renewal, the authors aimed to determine whether the inconsistencies between in vitro and in vivo studies are a result of differential effects of mesenchymal stem cells on the heterogeneous cell population within lung cancer cell lines. [Mol Cell Biochem] Abstract

REVIEWS

UI Researchers Developing 3D Printer, ‘Bio-Ink’ to Create Human Organs
Using its facilities for engineering living tissue systems, the Biomanufacturing Laboratory at University of Iowa (UI) College of Engineering’s Center for Computer Aided Design is working to develop and refine various 3D printing processes required for organ and tissue fabrication. [The University of Iowa]
Press Release

ReNeuron Wins Two Major Biomedical Catalyst Grants to Pursue Core Stem Cell Therapy Programs
ReNeuron Group plc announced that it has been awarded two separate grants, totaling £1.2 million, from the UK Biomedical Catalyst to pursue further development of two of its core stem cell therapy candidates. The first award to ReNeuron of £0.4 million is a Late Stage Biomedical Catalyst grant and relates to the Company’s ReN009 stem cell therapy candidate for critical limb ischemia. The second award of £0.8 million is an Early Stage Biomedical Catalyst grant and relates to the Company’s ReN003 stem cell candidate for the treatment of retinitis pigmentosa. [ReNeuron Group plc] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW 2013 Royal College of Pathologists Stem Cell Event Trilogy
June 4-6, 2013
London, United Kingdom

Visit our events page to see a complete list of events in the mesenchymal cell community.

Full Professorship – Stem Cell Biology (Helmholtz Zentrum Munchen)

Postdoctoral Position – Dysregulation of Hematopoietic and Mesenchymal Stem Cells (Indiana University)

Lecturer or Reader – Associate Professor (University of Reading)

Postdoctoral Position – Cardiopulmonary Molecular Biology (Hannover Medical School)

Postdoctoral Positions – Angiogenesis and Human Mesenchymal Stem Cell Biology (Boston University)

Postdoctoral Position – Stem Cell Development (Stony Brook University)


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