Volume 5.29 | Jul 30

Mesenchymal Cell News 5.29 July 30, 2013
Mesenchymal Cell News
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The Transcription Factor Sox11 Enhances Early Osteoblast Differentiation by Facilitating Proliferation and the Survival of Mesenchymal and Osteoblast Progenitors
Scientists identified that Sox11 is an important transcription factor for regulating the proliferation and survival of osteoblast precursor cells as well as the self renewal potency of mesenchymal progenitor cells via upregulation of Tead2. [J Cell Biol] Abstract | Full Article
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PUBLICATIONS (Ranked by impact factor of the journal)
Determination of Mesenchymal Stem Cell Fate by Pigment Epithelium-Derived Factor (PEDF) Results in Increased Adiposity and Reduced Bone Mineral Content
Since mesenchymal stem cell (MSC) differentiation into adipocytes vs. osteoblasts can be regulated by specific factors, PEDF-directed dependency of murine and human MSCs was assessed. PEDF inhibited adipogenesis and promoted osteoblast differentiation of murine MSCs, osteoblast precursors, and human MSCs. [FASEB J] Abstract

Interferon-ß Gene-Modified Human Bone Marrow Mesenchymal Stem Cells Attenuate Hepatocellular Carcinoma through Inhibiting AKT/FOXO3a Pathway
Scientists investigated the using of bone marrow mesenchymal stem cells genetically engineered to produce interferon-ß as a gene delivery system to treat hepatocellular carcinoma in vitro and in vivo. [Brit J Cancer] Abstract

Platelet Rich Plasma Clot Releasate Preconditioning Induced PI3K/AKT/NF?B Signaling Enhances Survival and Regenerative Function of Rat Bone Marrow Mesenchymal Stem Cells in Hostile Microenvironments
Researchers describe novel effects of platelet rich clot releasate on rat bone marrow mesenchymal stem cells, with the former driving a gene program which can reduce apoptosis and promote the regenerative function of the latter in hostile microenvironments through enhancement of paracrine/autocrine factors. [Stem Cells Dev] Abstract

BKCa and hEag1 Channels Regulate Cell Proliferation and Differentiation in Human Bone Marrow-Derived Mesenchymal Stem Cells
Scientists investigated potential roles of large-conductance Ca2+-activated potassium (BKCa) channels and ether-à-go-go potassium (hEag1 or Kv10.1) channels in regulating cell proliferation and differentiation in human mesenchymal stem cells. [J Cell Physiol] Abstract

Inhibition of Wnt/ß-Catenin Signaling Promotes Engraftment of Mesenchymal Stem Cells to Repair Lung Injury
Investigators found that activated Wnt/ß-catenin signaling may regulate the differentiation of mesenchymal stem cells and is associated with lung fibroblasts activation, pulmonary fibrosis and tissue repair process in acute lung injury rats. [J Cell Physiol] Abstract

Mesenchymal Stem Cells from iPS Cells Facilitate Periodontal Regeneration
Researchers successfully induced induced pluripotent stem cells (iPSC) to differentiate into mesenchymal stem cells (MSC)-like cells. The MSC-like cells generated satisfied the International Society of Cellular Therapy’s minimal criteria for defining multipotent MSC, since they had plastic adherent properties, expressed key MSC-associated markers, and had the capacity to undergo tri-lineage differentiation. [J Dent Res] Abstract

CXCR4-Overexpressing Bone Marrow-Derived Mesenchymal Stem Cells Improve Repair of Acute Kidney Injury
Scientists tested the hypothesis that CXCR4 overexpression improves bone marrow-derived mesenchymal stem cells’ repair ability and that this is related to increased release of cytokines. [Am J Physiol Renal Physiol] Abstract

A Negative Correlation between Per1 and Sox6 Expression during Chondrogenic Differentiation in Pre-Chondrocytic ATDC5 Cells
Scientists previously showed upregulation by parathyroid hormone (PTH) of the clock gene Period-1 (Per1) through the cAMP/protein kinase A signaling pathway in pre-chondrocytic ATDC5 cells. In this study, they investigated the role of Per1 in the suppression of chondrogenic differentiation by PTH. [J Pharmacol Sci] Abstract | Full Article

Sustained Release of Bone Morphogenetic Protein 2 via Coacervate Improves the Osteogenic Potential of Muscle-Derived Stem Cells
Prolonged exposure to bone morphogenetic protein (BMP)2 released by the poly(ethylene argininylaspartate diglyceride):heparin delivery system promoted the differentiation of muscle-derived stem cells to an osteogenic lineage in vitro and induced the formation of viable bone at an ectopic site in vivo. [Stem Cells Transl Med] Abstract

Multipotent Human Mesenchymal Stromal Cells Mediate Expansion of Myeloid-Derived Suppressor Cells via Hepatocyte Growth Factor/c-Met and STAT3
Researchers report that human mesenchymal stromal cells (MSCs) can expand CD14CD11b+CD33+ human myeloid-derived suppressor cells (MDSCs). MSC-expanded MDSCs suppress allogeneic lymphocyte proliferation, express arginase-1 and inducible nitric oxide synthase, and increase the number of regulatory T lymphocytes. [Stem Cells Rep] Abstract | Graphical Abstract | Full Article

New TeSR™-E8™ is Here For Feeder-Free Culture of Human ES Cells and iPS Cells
Perspectives on the Use of Mesenchymal Stem Cells in Vascularized Composite Allotransplantation
This authors provide an overview of the experimental basis, the scientific background and clinical applications of stem cell-based therapies in the field of reconstructive allotransplantation. [Front Immunol] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.
Stem Cell Agency’s Board Approves $70 Million Plan to Develop Innovative Alpha Clinics
A $70 million plan to create a new statewide network of sites that will act as a hub for stem cell clinical trials was approved by the governing Board of California’s stem cell agency, the California Institute for Regenerative Medicine. [California Institute for Regenerative Medicine] Press Release

Brazilian, Indian and Chinese Markets For Orthopedic Soft Tissue Solutions Will Grow Rapidly to Reach $500 Million by 2021
According to Millennium Research Group, expanding health care infrastructure and favorable demographics will drive rapid expansion in the Brazilian, Indian and Chinese orthopedic soft tissue solutions market, which will reach a value of approximately $500 million in 2021. [Millennium Research Group] Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW IBC’s 3rd Annual Cell Therapy Bioprocessing
October 21-22, 2013
Bethesda, United States

NEW IBC’s Biopharmaceutical Development & Production (BDP) Week: Methods & Molecules
March 24-27, 2014
San Diego, United States

Visit our events page to see a complete list of events in the mesenchymal cell community.
NEW Senior Scientist – Translational Medicine (Celgene Corporation)

Postdoctoral Research Associate – Cell-Material Interactions on Cellular Differentiation and Tissue Formation (University of Texas Health Science Center)

PhD Studentship – Mechanobiology of Stem Cells (Queen Mary University of London)

Postdoctoral Position – Cardiopulmonary Molecular Biology (Hannover Medical School)

Two PhD Students and One Postdoc – Molecular Cell Biology and Hematopoiesis (Sanquin)

Postdoctoral Fellow – Visualization of Gene Expression Promoting Mesenchymal Stem Cell Tropism (Johns Hopkins University School of Medicine)

Director of Cell Processing Facility (S L Collins Associates, Inc.)

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