Volume 5.31 | Aug 13

Mesenchymal Cell News 5.31 August 13, 2013
Mesenchymal Cell News
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Thalidomide Corrects Impaired Mesenchymal Stem Cell Function in Inducing Tolerogenic DCs in Patients with Immune Thrombocytopenia
Scientists demonstrated that mesenchymal stem cells in immune thrombocytopenia patients had reduced proliferative capacity and lost their immunosuppressive function, which could be corrected with thalidomide treatment. [Blood] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
TSG-6 Released from Intradermally Injected Mesenchymal Stem Cells Accelerates Wound Healing and Reduces Tissue Fibrosis in Murine Full-Thickness Skin Wounds
Using a complementary approach of in vitro and in vivo studies, scientists addressed the question whether mesenchymal stem cells-due to their anti-inflammatory properties-would control macrophage activation and tissue fibrosis in a murine model of full-thickness skin wounds. [J Invest Dermatol] Abstract

Myeloma Plasma Cells Alter the Bone Marrow Microenvironment by Stimulating the Proliferation of Mesenchymal Stromal Cells
Researchers used mesenchymal stromal cell and osteoblast-related cell surface marker expression and flow cytometry to enumerate mesenchymal stromal cell and osteoblast numbers in bone marrow recovered from myeloma patients at the time of diagnosis. [Haematol] Abstract | Full Article

A Novel Strontium(II)-Modified Calcium Phosphate Bone Cement Stimulates Human-Bone-Marrow-Derived Mesenchymal Stem Cell Proliferation and Osteogenic Differentiation In Vitro
The in vitro effects of novel strontium-modified calcium phosphate bone cements, prepared using two different approaches on human-bone-marrow-derived mesenchymal stem cells, were evaluated. [Acta Biomater] Abstract | Graphical Abstract

Collagen Hydrogels Incorporated with Surface-Aminated Mesoporous Nanobioactive Glass: Improvement of Physicochemical Stability and Mechanical Properties Effective for Hard Tissue Engineering
Mesenchymal stem cells cultivated within a collagen-mesoporous bioactive glass nanoparticle (mBGn) hydrogels were highly viable with enhanced cytoskeletal extensions due to the addition of surface aminated mBGn. [Acta Biomater] Abstract

Cytoplasmic-Targeted Parvalbumin Blocks the Proliferation of Multipotent Mesenchymal Stromal Cells in Prophase
Investigators showed that the adenoviral-parvalbumin-nuclear exclusion signal-Discosoma red fluorescent protein fusion protein decreased serum-induced Ca2+ signaling and blocked the proliferation of rat adipose-derived mesenchymal stromal cells in prophase. [Stem Cell Res Ther] Abstract | Full Article

Comparative Proteome Approach Demonstrates that Platelet-Derived Growth Factor C and D Efficiently Induce Proliferation while Maintaining Multipotency of hMSCs
Scientists describe the effects of the platelet-derived growth factor (PDGF) isoforms C and D during in vitro expansion of human mesenchymal stem cells (hMSCs). Their results showed that PDGFs can enhance proliferation of hMSCs without affecting their multipotency. [Exp Cell Res] Abstract

Isolation of Mesenchymal Stem-Like Cells in Meningioma Specimens
Researchers hypothesized that cells similar to bone marrow mesenchymal stem cells exist in meningioma specimens and sought to investigate whether these putative meningioma stroma mesenchymal stem-like cells could be isolated. [Int J Oncol] Abstract

Antioxidants Cause Rapid Expansion of Human Adipose-Derived Mesenchymal Stem Cells via CDK and CDK Inhibitor Regulation
Human adipose-derived mesenchymal stem cells (ADMSCs) cultured in ImF-A medium supplemented with antioxidants and fibroblast growth factor 2 (FGF-2) were compared with ADMSCs cultured with FGF-2 alone or with FGF-2 under 5% pO2 conditions. [J Biomed Sci] Abstract

Cyclic Tensile Strain Enhances Osteogenesis and Angiogenesis in Human Mesenchymal Stem Cells from Osteoporotic Donors
Researchers demonstrated that human mesenchymal stem cells from aged, osteoporotic donors are capable of enhanced osteogenic differentiation in response to 10% cyclic tensile strain with significant increases in expression of genes associated with enhanced cell proliferation, musculoskeletal development, and angiogenesis. [Tissue Eng Part A] Abstract

rFN/Cad-11-Modified Collagen Type II Biomimetic Interface Promotes the Adhesion and Chondrogenic Differentiation of Mesenchymal Stem Cells
Scientists showed that a designed material was able to stimulate cell proliferation and promote better chondrogenic differentiation of rabbit mesenchymal stem cells in vitro than FN modified surfaces and the negative control. [Tissue Eng Part A] Abstract

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Adipose Tissue-Derived Stem Cells in Clinical Applications
The authors focus on reported clinical applications of adipose tissue derived stem cells and discusses technical approaches of their isolation and processing. [Expert Opin Biol Ther] Abstract

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Cardium Reports on Potential Use of Excellagen to Repair Prenatally Diagnosed Birth Defects Using Mesenchymal Stem Cells
Cardium Therapeutics reported on a research collaboration with researchers at Boston Children’s Hospital, to assess the medical utility of Excellagen® as a delivery scaffold to seed autologous mesenchymal fetal stem cells for ex vivo engineering of tissue grafts for transplantation into infants to repair prenatally diagnosed birth defects. [Cardium Therapeutics] Press Release

Grafix® Demonstrates Overwhelming Efficacy in Landmark Stem Cell Study for the Treatment of Diabetic Foot Ulcers
Osiris Therapeutics, Inc. reported that its multi-center, randomized, controlled clinical trial comparing the safety and effectiveness of Grafix® to standard of care in patients with chronic diabetic foot ulcers had met the pre-specified stopping rules for overwhelming efficacy as determined by the data monitoring committee during a planned interim analysis. Grafix® is a human cellular repair matrix that provides a high-quality source of living mesenchymal stem cells. [Osiris Therapeutics, Inc.] Press Release

Stem Cell Society Singapore 2013 Symposium
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

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NEW 8th National Cancer Research Institute Conference
November 3-6, 2013
Liverpool, United Kingdom

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NEW Tenure-Track Fellowship – Musculoskeletal Regenerative Medicine (The University of Liverpool)

NEW Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Postdoctoral Fellow – Regeneration of Cartilage and Ligament Tissue (University of California, Los Angeles)

Senior Scientist – Translational Medicine (Celgene Corporation)

PhD Studentship – Mechanobiology of Stem Cells (Queen Mary University of London)

Postdoctoral Position – Cardiopulmonary Molecular Biology (Hannover Medical School)

Director of Cell Processing Facility (S L Collins Associates, Inc.)

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