Volume 5.32 | Aug 20

Mesenchymal Cell News 5.32 August 20, 2013
Mesenchymal Cell News
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Mesenchymal Stem Cells Alleviate Bacteria-Induced Liver Injury in Mice by Inducing Regulatory Dendritic Cells
Researchers used Propionibacterium acnes (P. acnes)-primed, lipopolysaccharide (LPS)-induced liver injury in mice as an animal model of human fulminant hepatic failure (FHF). They demonstrated that administration of mesenchymal stem cells significantly ameliorated liver injury and improved the survival rates of mice subjected to P. acnes plus LPS-induced FHF. [Hepatology] Abstract
Achieve Superior Differentiation of Mouse MSC & MEF into Osteoblasts with the New MesenCult™ Osteogenic Stimulatory Kit (Mouse)
PUBLICATIONS (Ranked by impact factor of the journal)
Transplants of Adult Mesenchymal and Neural Stem Cells Provide Neuroprotection and Behavioral Sparing in a Transgenic Rat Model of Huntington’s Disease
Researchers aimed to compare the efficacy of transplants of mesenchymal stem cells (MSCs), adult neural stem cells (aNSCs), or co-transplants of MSCs and aNSCs for reducing deficits in a transgenic rat model of Huntington’s disease (HD). HD rats received intrastriatal transplantations of 400,000 MSCs, aNSCs, or a combination of MSCs/aNSCs, while wild-type and HD controls were given vehicle. [Stem Cells] Abstract

FGFR1 Signaling Stimulates Proliferation of Human Mesenchymal Stem Cells by Inhibiting the Cyclin-Dependent Kinase Inhibitors P21Waf1 and P27Kip1
Using siRNA depletion, antibody-inhibition and small molecule inhibition, researchers established that Fibroblast Growth Factor Receptor 1 (FGFR1) activity is rate-limiting for self-renewal of human adult mesenchymal stem cells. They showed that FGFR1 promotes stem cell proliferation through multiple mechanisms that unite to antagonize cyclin-dependent kinase inhibitors. [Stem Cells] Abstract

Human Mesenchymal Stem Cell Microvesicles for Treatment of E.coli Endotoxin-Induced Acute Lung Injury in Mice
Scientists examined whether microvesicles released by human bone marrow derived mesenchymal stem cells (MSC) would be effective in restoring lung protein permeability and reducing inflammation in E.coli endotoxin-induced acute lung injury (ALI) in C57BL/6 mice. They found that human MSC derived microvesicles were therapeutically effective following E.coli endotoxin-induced ALI in mice in part through the expression of keratinocyte growth factor mRNA in the injured alveolus. [Stem Cells] Abstract

Adipose Tissue-Derived Stromal Stem Cell Therapy in Murine ConA-Derived Hepatitis Is Dependent on Myeloid-Lineage and CD4+ T-Cell Suppression
Researchers investigated the immunomodulatory effect of adipose tissue-derived stromal stem cells (ADSCs) on hepatitis using an acute ConA C57BL/6 murine hepatitis model. Intravenous administration of ADSCs simultaneously or 3 h post injection prevented and treated ConA-induced hepatitis. [Eur J Immunol] Abstract

Human Umbilical Cord Mesenchymal Stem Cell Therapy for Patients with Active Rheumatoid Arthritis: Safety and Efficacy
Scientists assessed the safety and efficacy of human umbilical cord mesenchymal stem cells (UC-MSCs) in the treatment of rheumatoid arthritis (RA). In this ongoing cohort, 172 patients with active RA who had inadequate responses to traditional medication were enrolled. Patients were divided into two groups for different treatment: Disease modifying anti-rheumatic drugs (DMARDs) plus medium without UC-MSCs, or DMARDs plus UC-MSCs group via intravenous injection. [Stem Cells Dev] Abstract

Thyroid Hormone-Induced Hypertrophy in Mesenchymal Stem Cell (MSC) Chondrogenesis Is Mediated by Bone Morphogenetic Protein-4 (BMP-4)
Chondrogenic differentiating MSCs express markers of hypertrophic growth plate chondrocytes. As hypertrophic cartilage undergoes ossification, this is a concern for the application of MSCs in articular cartilage tissue engineering. In order to identify mechanisms that elicit this phenomenon, the authors used an in vitro hypertrophy model of chondrifying MSCs for differential gene expression analysis and functional experiments with the focus on BMP signaling. [Tissue Eng Part A] Abstract

Adipogenic Potential in Human Mesenchymal Stem Cells Strictly Depends on Adult or Fetal Tissue Harvest
Researchers compared the adipogenic potential of mesenchymal stem cells (MSC) originated from two adult sources as fat pads and bone marrow, and from four fetal sources as umbilical cord blood, Wharton’s jelly, amniotic fluid and preterm umbilical cord perivascular cells. Surprisingly, adult MSC displayed higher differentiation capacities confirmed by gene expression analysis on a selected panel of adipogenesis-related genes. [Int J Biochem Cell Biol] Abstract

Mesenchymal Stem Cells Exploit Extracellular Matrix as Mechanotransducer
Researchers showed that human mesenchymal stem cells (hMSCs) harvest and assemble plasma fibronectin into their extracellular matrix (ECM) fibrils within 24 hours. hMSCs pro-actively pull on newly assembled fibronectin ECM fibrils, and the fibers are more stretched on rigid than on soft fibronectin-coated polyacrylamide gels. [Sci Rep] Full Article

Umbilical Cord Mesenchymal Stem Cell Transplantation Significantly Improves Neurological Function in Patients with Sequelae of Traumatic Brain Injury
Researchers investigated the effects of transplantation with umbilical cord mesenchymal stem cells in patients with sequelae of traumatic brain injury (TBI). The study hypothesis was that umbilical cord mesenchymal stem cell transplantation could safely and effectively improve neurological function in patients with sequelae of TBI. [Brain Res] Abstract

Genetically Engineered Bone Marrow Mesenchymal Stem Cells Improve Functional Outcome in a Rat Model of Epilepsy
There is little research focusing on the multi-potency of bone marrow mesenchymal stem cells (BMSCs) in the treatment of epilepsy, the present study was designed to examine the influence of genetically engineered BMSCs on the functional outcome in a rat model of epilepsy. [Brain Res] Abstract

Technical Bulletin: Assays For Cord Blood
Stromal Cells in Tissue Homeostasis: Balancing Regeneration and Fibrosis
Mesenchymal stromal cells (MSCs) may enhance the intrinsic reparative capabilities of the kidney. This Perspectives article considers the innate regenerative potential of the kidney in the context of ongoing studies of MSC therapy. [Nat Rev Nephrol] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.
FDA Approves MSC-NP Therapy as Investigational New Drug in MS Clinical Trial: A Research Milestone
The stem cell research division of the Tisch MS Research Center of New York announced Food and Drug Administration (FDA) approval of autologous, mesenchymal stem cell-derived neural progenitor cells (MSC-NPs) as an Investigational New Drug for an open label, Phase I clinical trial in the treatment of multiple sclerosis (MS). [Tisch MS Research Center of New York] Press Release

Grafix® Demonstrates Overwhelming Efficacy in Landmark Stem Cell Study for the Treatment of Diabetic Foot Ulcers
Osiris Therapeutics, Inc. reported that its multi-center, randomized, controlled clinical trial comparing the safety and effectiveness of Grafix® to standard of care in patients with chronic diabetic foot ulcers had met the pre-specified stopping rules for overwhelming efficacy as determined by the data monitoring committee during a planned interim analysis. Grafix is a human cellular repair matrix containing living stem cells for acute and chronic wound repair. [Osiris Therapeutics, Inc.] Press Release

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NEW World Stem Cell Summit (WSCS) 2013
December 4-6, 2013
San Diego, United States

Visit our events page to see a complete list of events in the mesenchymal cell community.
NEW Principal Investigator – Developmental & Stem Cell Biology (SickKids Hospital)

Tenure-Track Fellowship – Musculoskeletal Regenerative Medicine (The University of Liverpool)

Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Postdoctoral Fellow – Regeneration of Cartilage and Ligament Tissue (University of California, Los Angeles)

Senior Scientist – Translational Medicine (Celgene Corporation)

PhD Studentship – Mechanobiology of Stem Cells (Queen Mary University of London)

Postdoctoral Position – Cardiopulmonary Molecular Biology (Hannover Medical School)

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