Volume 5.33 | Aug 27

Mesenchymal Cell News 5.33 August 27, 2013
Mesenchymal Cell News
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miR-146a-5p Circuitry Uncouples Cell Proliferation and Migration, but Not Differentiation, in Human Mesenchymal Stem Cells
Knockdown of miR-146a-5p in Wharton’s jelly-mesenchymal stem cells (MSCs) inhibited their proliferation yet enhanced their migration, whereas overexpression of miR-146a-5p in bone marrow-MSCs did not influence their osteogenic and adipogenic potentials. [Nucleic Acids Res] Full Article
Directed Differentiation of Pluripotent Stem Cells - A Cell Stem Cell Poster
PUBLICATIONS (Ranked by impact factor of the journal)
Protein Kinase Inhibitor ? Reciprocally Regulates Osteoblast and Adipocyte Differentiation by Downregulating Leukemia Inhibitory Factor
Investigators determined whether endogenous levels of Pkig regulate osteoblast differentiation. Pkig is the primary family member in MEFs, murine marrow-derived mesenchymal stem cells, and human mesenchymal stem cells. Pkig deletion increased forskolin-dependent nuclear PKA activation and gene expression and Pkig deletion or knockdown increased osteoblast differentiation. [Stem Cells] Abstract

Withaferin A: A Proteasomal Inhibitor Promotes Healing after Injury and Exerts Anabolic Effect on Osteoporotic Bone
Researchers showed that one of the withanolides, withaferin A acts as a proteasomal inhibitor and binds to specific catalytic ß subunit of the 20S proteasome. It exerts positive effect on osteoblasts by increasing osteoblast proliferation and differentiation. [Cell Death Dis] Full Article

Rutaecarpine Analogues Reduce Lipid Accumulation in Adipocytes via Inhibiting Adipogenesis/Lipogenesis with AMPK Activation and UPR Suppression
Rutaecarpine and its novel analogues were identified to exert potent effect in reducing lipid accumulation during adipocyte differentiation in 3T3-L1 adipocytes with little cytotoxicity. [ACS Chem Biol] Abstract

Systemic Administration of Exosomes Released from Mesenchymal Stromal Cells Promote Functional Recovery and Neurovascular Plasticity after Stroke in Rats
Scientists tested a novel hypothesis that systemic treatment of stroke with exosomes derived from multipotent mesenchymal stromal cells promote neurovascular remodeling and functional recovery after stroke in rats. [J Cereb Blood Flow Metab] Full Article | Press Release

Inflammatory Cytokines Induce an Unique Mineralizing Phenotype in Mesenchymal Stem Cells Derived from Human Bone Marrow
Little is known of the biological responses of human mesenchymal stem cells to inflammatory conditions. When cultured with IL-1ß, marrow-derived MSCs from eight of ten human subjects deposited copious hydroxyapatite, whose authenticity was confirmed by Fourier transform infra-red spectroscopy. [J Biol Chem] Abstract | Full Article

Hypoxia Promotes Redifferentiation and Suppresses Markers of Hypertrophy and Degeneration in Both Healthy and Osteoarthritic Chondrocytes
Researchers assessed whether healthy and osteoarthritis chondrocytes have distinct responses to oxygen, particularly with regard to hypertrophy and degradation during redifferentiation. [Arthritis Res Ther]
Abstract | Full Article

Glucocorticoid Receptor Antagonist and siRNA Prevent Senescence of Human Bone Marrow Mesenchymal Stromal Cells In Vitro
Scientists investigated the effects mediated by glucocorticoid receptor (GR) blockage by using RU486, a GR antagonist and GR short interfering RNA (GR siRNA) on the proliferative and differentiation capabilities of human bone marrow mesenchymal stromal/stem cells and on their senescence and antioxidant levels during extended in vitro culture. [Cell Tissue Res] Abstract

Regulation of Differentiation in Trabecular Bone-Derived Mesenchymal Stem Cells by T Cell Activation and Inflammation
Scientists investigated the effects of T cell activation and inflammation on the differentiation of mesenchymal stem cells. [Oncol Rep] Abstract

Gene Expression Responses to Mechanical Stimulation of Mesenchymal Stem Cells Seeded on Calcium Phosphate Cement
Scientists investigated the molecular responses of human mesenchymal stem cells to loading with a model that attempts to closely mimic the physiological mechanical loading of bone, using monetite calcium phosphate scaffolds to mimic the biomechanical properties of bone and a bioreactor to induce appropriate load and strain. [Tissue Eng Part A] Abstract

View Technical Data: Superior Chondrogenic Differentiation Potential of MesenCult-XF Cultured MSCs
Aging-Related Genes in Mesenchymal Stem Cells: A Mini-Review
The authors amass and discuss the recent data related to age-associated genes in mesenchymal stem cells (MSCs). In particular, the activities of epigenetic regulatory factors, including histone acetylase and DNA methyltransferase, modulate gene expression and crosstalk with each other during the MSC senescence process. [Gerontology] Full Article

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Okyanos Heart Institute Inks Deal with International Med-X and Philips Healthcare for Cardiac Cath Lab Equipment to Treat Heart Disease Patients with Adult Stem Cell Therapy
Okyanos Heart Institute announced that it has selected International Med-X and Philips Healthcare as its partner to establish the Bahamas’ first cath lab for stem cell therapy. [Vocus PRW Holdings, LLC]
Press Release

BioTime CEO Dr. Michael West to Give Keynote Address at the MSC 2013 Adult Stem Cell Therapy & Regenerative Medicine Conference
BioTime, Inc. announced that Chief Executive Officer Michael D. West, PhD will give the keynote address at the MSC 2013 Adult Stem Cell Therapy & Regenerative Medicine conference. Dr. West will discuss the potential use of embryonic mesenchymal progenitor cells, generated using BioTime’s PureStem™ technology, in regenerative medicine and will contrast the properties of those cells with adult-derived mesenchymal stem cells. [BioTime, Inc.] Press Release

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April 23-26, 2014
Paris, France

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NEW Senior Scientist – Characterizing Mesenchymal Cell Activity (Celgene Corporation)

Principal Investigator – Developmental & Stem Cell Biology (SickKids Hospital)

Tenure-Track Fellowship – Musculoskeletal Regenerative Medicine (The University of Liverpool)

Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Postdoctoral Fellow – Regeneration of Cartilage and Ligament Tissue (University of California, Los Angeles)

PhD Studentship – Mechanobiology of Stem Cells (Queen Mary University of London)

Postdoctoral Position – Cardiopulmonary Molecular Biology (Hannover Medical School)

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