Volume 5.39 | Oct 8

Mesenchymal Cell News 5.39 October 8, 2013
Mesenchymal Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Nanotubular Crosstalk with Distressed Cardiomyocytes Stimulates the Paracrine Repair Function of Mesenchymal Stem Cells
Researchers addressed whether cell-to-cell communication processes between mesenchymal stem cells (MSC) and suffering cardiomyocytes, and more particularly those involving tunneling nanotubes, control the MSC paracrine regenerative function. [Stem Cells] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
C/EBPβ Expressed by Bone Marrow Mesenchymal Stromal Cells Regulates Early B-Cell Lymphopoiesis
The role of CCAAT/enhancer-binding protein β (C/EBPβ) expressed by bone marrow mesenchymal stromal cells in B-cell lymphopoiesis was examined. The size of the precursor B-cell population in bone marrow was reduced in C/EBPβ-knockout mice. [Stem Cells] Abstract

The Effect of the Coumarin-Like Derivative Osthole on the Osteogenic Properties of Human Periodontal Ligament and Jaw Bone Marrow Mesenchymal Stem Cell Sheets
Researchers investigated the biological effects of osthole, a coumarin-like derivative extracted from Chinese herbs, on the cell sheet formation and osteogenic properties of human periodontal ligament stem cells and jaw bone marrow mesenchymal stem cells. [Biomaterials] Abstract

Dexamethasone Shifts Bone Marrow Stromal Cells from Osteoblasts to Adipocytes by C/EBPalpha Promoter Methylation
Scientists established a dexamethasone (Dex)-induced osteoporotic mouse model, and found that bone marrow stromal cells from Dex-treated mice are more likely to differentiate into adipocytes than those from control mice, even under the induction of bone morphogenetic protein-2. [Cell Death Dis] Full Article

Biocompatibility of Silver Nanoparticles and Silver Ions in Primary Human Mesenchymal Stem Cells and Osteoblasts
Scientists evaluated the influence of silver nanoparticles on cell stress, viability, proliferation and differentiation of primary human mesenchymal stem cells and osteoblasts. [Acta Biomater] Abstract

The Adipose-Derived Lineage-Negative Cells Are Enriched Mesenchymal Stem Cells and Promote Limb Ischemia Recovery in Mice
Researchers systematically characterized the adipose tissue-derived lineage-negative (Lin-) cell population using various surface markers and a set of cell proliferation and differentiation assays. They demonstrated clearly that the Lin- cell population represents enriched mesenchymal stem cells (MSCs), which were identified by their high expression of MSC surface markers, and that these cells are a robust population with a vigorous growth capability and delayed aging. [Stem Cells Dev] Abstract

A Signal-Amplification Circuit Between miR-218 and Wnt/β-Catenin Signal Promotes Human Adipose Tissue-Derived Stem Cells Osteogenic Differentiation
Scientists present evidence that microRNA (miR)-218 acts as a positive regulator of human adipose-derived stem cells osteogenesis. Real-time PCR showed that miR-218 was up-regulated during osteogenic differentiation. [Bone] Abstract

Alternative Splicing Targeting the hTAF4-TAFH Domain of TAF4 Represses Proliferation and Accelerates Chondrogenic Differentiation of Human Mesenchymal Stem Cells
Researchers studied tissue distribution and cellular expression of different splice variants of transcription factor IID subunit TAF4 mRNA and biochemical properties of its isoforms in human mesenchymal stem cells to reveal the role of different isoforms of TAF4 in the regulation of proliferation and differentiation. [PLoS One] Full Article

Activation of Human Mesenchymal Stem Cells Impacts Their Therapeutic Abilities in Lung Injury by Increasing Interleukin (IL)-10 and IL-1RN Levels
The objective of this study was to improve the protective anti-inflammatory capacity of human mesenchymal stem cells (hMSCs) by evaluating the consequences of preactivating hMSCs before use in a murine model of acute respiratory distress syndrome. Minimally manipulated hMSCs were more efficient at reducing lung inflammation compared with isolated and in vitro expanded hMSCs obtained from bone marrow aspirates. [Stem Cells Transl Med] Abstract

Human Placental Alkaline Phosphatase as a Tracking Marker for Bone Marrow Mesenchymal Stem Cells
Researchers showed that bone marrow mesenchymal stem cells from wild type and human placental alkaline phosphatase (hPLAP)-transgenic inbred F344 rats donors are indistinguishable in terms of cell morphology, viability, adhesion, immune phenotype, and proliferation as well as in their differentiation capacity over six passages. [Biores Open Access] Full Article

Delivery of Functional Anti-miR-9 by Mesenchymal Stem Cell-Derived Exosomes to Glioblastoma Multiforme Cells Conferred Chemosensitivity
Although miRs are attractive targets for cancer therapeutics, the effectiveness of this approach requires targeted delivery. Mesenchymal stem cells can migrate to the sites of cancers, including glioblastoma multiforme (GBM). Researchers report on an increase in microRNA (miR)-9 in temozolomide-resistant GBM cells. [Mol Ther Nucleic Acids] Full Article

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REVIEWS
Mesenchymal Stromal Cells: Sensors and Switchers of Inflammation
The authors outline current insights into the ways in which mesenchymal stromal cells sense and control inflammation, highlighting the central role of macrophage polarization. They also draw attention to functional differences seen between in vivo and in vitro contexts and between species. [Cell Stem Cell] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.
 
INDUSTRY NEWS
Bone Therapeutics Receives Clearance for ALLOB® Phase I/IIa Trial
Bone Therapeutics announced that it has received clearance from the Competent Authorities in Belgium and the UK for a Phase I/IIa trial with its allogeneic cell therapy product ALLOB® for the treatment of delayed union fractures. [Bone Therapeutics S.A.] Press Release

TrakCel Accelerates Stem Cell Logistics Solution Development with Welsh Government Funding
TrakCel has announced it will commence trials with leading international pharmaceutical company GlaxoSmithKline in early 2014. Benefiting from an initial £100,000 from the Welsh Government SMART Cymru award for Research Development and Innovation, TrakCel has been able to swiftly develop demonstrable initial technology and present it to key players in the industry including GlaxoSmithKline. [Biotec Services International] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

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EVENTS
NEW International Federation for Adipose Therapeutics and Science
November 21-24, 2013
New York City, United States

Visit our events page to see a complete list of events in the mesenchymal cell community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Fellow – Adipose Mesenchymal Stem Cells For Retinal Disease (University of Virginia)

Postdoctoral Research Fellow – Stem Cells (Bioprocessing Technology Institute)

9 PhD Positions and 1 Postdoctoral Position – Tissue Engineering and Regenerative Medicine (RUNMC)

Faculty Positions – Stem Cells and Regenerative Medicine (Baylor College of Medicine)

Postdoctoral Position – Cell Delivery Systems in Bone Repair (Fujifilm)

PhD Position – Biomaterial Imaging (Uppsala University)

Postdoctoral Position – Cardiopulmonary Molecular Biology (Hannover Medical School)

Principal Investigator – Developmental & Stem Cell Biology (SickKids Hospital)

Scientist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Research Technologist – Mesenchymal Cell Research (STEMCELL Technologies Inc.)

Research Technologist – Cell Culture Media & Matrices (STEMCELL Technologies Inc.)

Research Associate/Scientist – Antibodies Group (STEMCELL Technologies Inc.)

Research Associate – Particle Chemistry (STEMCELL Technologies Inc.)

Quality Control Analyst – Media (STEMCELL Technologies Inc.)


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