Volume 6.02 | Jan 21

Mesenchymal Cell News 6.02 January 21, 2014
Mesenchymal Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Miro1 Regulates Intercellular Mitochondrial Transport & Enhances Mesenchymal Stem Cell Rescue Efficacy
Investigators demonstrated that overexpression of Miro1 in mesenchymal stem cells leads to enhanced mitochondrial transfer and rescue of epithelial injury, while Miro1 knockdown leads to loss of efficacy. [EMBO J] Abstract | Press Release | Video
View Technical Data: Superior Chondrogenic Differentiation Potential of MesenCult-XF Cultured MSCs
 
PUBLICATIONS (Ranked by impact factor of the journal)
Importance of SOX8 for In Vitro Chondrogenic Differentiation of Human Mesenchymal Stromal Cells
Scientists demonstrated that SOX8 mRNA levels decrease during in vitro dedifferentiation of human articular chondrocytes and increase during chondrogenic differentiation of mesenchymal stromal cells. [Stem Cells] Abstract

Adhesion and Proliferation of Human Mesenchymal Stem Cells from Dental Pulp on Porous Silicon Scaffolds
The behavior of human dental pulp stem cells were analyzed on porous silicon substrates presenting pore of various sizes and undergoing different chemical treatments: thermal oxidation, silanization with aminopropyltriethoxysilane, and hydrosilylation with undecenoic acid or semicarbazide. [ACS Appl Mater Interfaces] Abstract

Human Mesenchymal Stromal Cells from Adult and Neonatal Sources: A Comparative In Vitro Analysis of Their Immunosuppressive Properties against T Cells
Researchers compared mesenchymal stromal cells (MSCs) from bone marrow (BM), umbilical cord blood (UCB) and placenta (PL) in terms of their immunosuppressive properties against lymphoid cell populations enriched for CD3+ T cells. Their results confirm the immunosuppressive potential of BM-MSCs, and demonstrated that MSCs from UCB and, to a lesser extent PL, also have immunosuppressive potential. [Stem Cells Dev] Abstract

pVEGF-Loaded Lipopolysaccharide-Amine Nanopolymersomes for Therapeutic Angiogenesis
Scientists have demonstrated that their newly developed lipopolysaccharide-amine nanopolymersomes have higher than 95% transfection efficiency when delivering pEGFP into mesenchymal stem cells (MSCs). To explore their clinical potential in therapeutic angiogenesis the scientists studied their toxicity, storage stability, protection ability to genes and efficacy to deliver therapeutic genes of pVEGF in MSCs and zebrafish. [Nanotechnology] Abstract

In Vitro and In Vivo Angiogenic Capacity of BM-MSCs/HUVECs and AT-MSCs/HUVECs Cocultures
Researchers comparatively evaluated the angiogenic capacity of cocultures using either human bone marrow- or human adipose tissue-derived mesenchymal stem cells (MSCs) (BM- or AT-MSCs) with human umbilical vein endothelial cells (HUVECs) both in vitro and in vivo at early time points. [Biofabrication] Abstract

Decellularized Silk Fibroin Scaffold Primed with Adipose Mesenchymal Stromal Cells Improves Wound Healing in Diabetic Mice
Researchers demonstrated, for the first time, that electrospun nanofibrous silk fibroin patches, cellularized with human adipose-derived mesenchymal stromal cells or decellularized are effective in the treatment of skin wounds, improving skin regeneration in db/db diabetic mice. [Stem Cell Res Ther] Abstract | Full Article

Human Cadaver Multipotent Stromal/Stem Cells Isolated from Arteries Stored in Liquid Nitrogen for 5 Years
Cadaveric vascular tissues were established as an alternative source of human cadaver mesenchymal stromal/stem cells. Scientists reported the successful cell isolation from post mortem arterial segments stored in a tissue-banking facility for at least 5 years. [Stem Cell Res Ther] Abstract | Full Article

Adult Human Mesenchymal Stem Cells Delivered via Intra-Articular Injection to the Knee Following Partial Medial Meniscectomy: A Randomized, Double-Blind, Controlled Study
In a randomized, double-blind, controlled study, the safety of the intra-articular injection of human mesenchymal stem cells into the knee, the ability of mesenchymal stem cells to promote meniscus regeneration following partial meniscectomy, and the effects of mesenchymal stem cells on osteoarthritic changes in the knee were investigated. [J Bone Joint Surg Am] Abstract | Press Release

Mesenchymal Stromal (Stem) Cells Suppress Pro-Inflammatory Cytokine Production but Fail to Improve Survival in Experimental Staphylococcal Toxic Shock Syndrome
Based on the critical role of host-derived immune mediators in toxic shock syndrome (TSS), scientists hypothesized that mesenchymal stromal (stem) cells could modulate the host-derived proinflammatory response triggered by Staphylococcal enterotoxin B and improve survival in experimental TSS. [BMC Immunol] Full Article

Human Bone Marrow-Derived Mesenchymal Stem Cells Display Enhanced Clonogenicity but Impaired Differentiation with Hypoxic Preconditioning
Scientists investigated the use of hypoxia as a preconditioning agent and in differentiating cultures to enhance mesenchymal stem cells function. They determined that enhanced clonogenicity was attributable to increased proliferation, increased vascular endothelial growth factor secretion, and increased matrix turnover. [Stem Cells Transl Med] Abstract

Novel SCRG1/BST1 Axis Regulates Self-Renewal, Migration, and Osteogenic Differentiation Potential in Mesenchymal Stem Cells
Researchers identified the human mesenchymal stem cell (hMSC)-secreted protein SCRG1 and its receptor BST1 as a positive regulator of self-renewal, migration, and osteogenic differentiation. SCRG1 and BST1 gene expression decreased during osteogenic differentiation of hMSCs. [Sci Rep] Full Article

Learn How to Assemble & Purge the Hypoxia Chamber Watch the Video
 
REVIEWS
Bone Marrow-Derived Mesenchymal Stem Cells Change Phenotype following In Vitro Culture: Implications for Basic Research and the Clinic
The authors provide an update on knowledge of mesenchymal stem cells (MSCs) in their native environment, focusing on bone marrow-derived MSCs. They provide a detailed description of the differences between naive cells and those that have been cultured in vitro and examine the effect of isolation and culture parameters on these phenotypic changes. [Stem Cells] Abstract | Full Article

Mesenchymal Stem Cells: Roles and Relationships in Vascularization
This review aims to provide a summary of relevant relationships between mesenchymal stem cells (MSCs), vascularization, and other relevant cell types, along with an overview discussing applications and challenges related to the role and relationship of MSCs and vascular tissues. [Tissue Eng Part B Rev] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

Hear from the leaders in the Cell Culture sector!
 
INDUSTRY NEWS
Cytori to Initiate U.S. Clinical Trial of Adipose-Derived Regenerative Cells in Hamstring Injuries
Cytori Therapeutics has received Investigational Device Exemption approval from the FDA to begin a prospective clinical trial to evaluate the safety and feasibility of Cytori Cell Therapy as a potential treatment for hamstring injuries. [Cytori Therapeutics] Press Release

Cardio3 BioSciences Receives IND Clearance from the FDA for its CHART-2 Phase III Heart Failure Clinical Trial
Cardio3 BioSciences announced that the U.S. Food and Drug Administration (FDA) has authorized the Company’s Investigational New Drug (IND) application for clinical testing of the Company’s proprietary regenerative medicine product C3BS-CQR-1 as a treatment targeting heart failure. [Cardio3 BioSciences]
Press Release

The HUB Foundation for Organoid Technology and STEMCELL Technologies Sign Agreement on the Manufacturing of Cell Culture Media for Organoids
The HUB Foundation for Organoid Technology announced that it has signed a licensing agreement with STEMCELL Technologies Inc. for the manufacturing and worldwide distribution of cell culture media for growing Organoids. [STEMCELL Technologies Inc.] Press Release

From our sponsor: Learn about assays for cord blood. Download the free technical bulletin.
 
POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW The Stem Cell Niche 2014
May 18-22, 2014
Copenhagen, Denmark

Visit our events page to see a complete list of events in the mesenchymal cell community.
 
JOB OPPORTUNITIES
NEW Senior Scientist – Stem Cell and Regenerative Medicine (Universidad de Los Andes)

Postdoctoral Fellow – Viral Gene Therapy for Ocular Diseases (University of Alberta)

Postdoctoral Researcher Position – Role of Muscle Stem Cells in Tissue Regeneration after Radiation Injury (IRSN [French Nuclear Safety Institute])

PhD Fellowship – Regenerative Medicine (UKSH)

Postdoctoral Position – Regenerative Medicine (Centro Cardiologico Monzino IRCCS)

Postdoctoral Position – Cardiopulmonary Molecular Biology (Hannover Medical School)

PhD Position – Human Cell Isolation and Controlled Expansion for Tuned Drug Release in Bone Repair (Medicyte)

Postdoctoral Position – Tissue Engineering and Regenerative Medicine (RUNMC)


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