Bone Marrow Mesenchymal Stem Cells and TGF-β Signaling in Bone Remodeling|
The spatiotemporal release and activation of matrix TGF-β during osteoclast bone resorption recruits mesenchymal stem cells (MSCs) to bone-resorptive sites. Dysregulation of TGF-β alters MSC fate, uncoupling bone remodeling and causing skeletal disorders. Modulation of TGF-β or parathyroid hormone signaling may reestablish coupled bone remodeling and be a potential therapy. [J Clin Invest]
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