Volume 6.04 | Feb 4

Mesenchymal Cell News 6.04 February 4, 2014
Mesenchymal Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
The Immunosuppressive Properties of Non-Cultured Dermal-Derived Mesenchymal Stromal Cells and the Control of Graft-versus-Host Disease
The authors described for the first time the use of non-cultured dermal-derived-mesenchymal stromal cells (DMSCs) for controlling graft-versus-host disease (GvHD) in an MHC-mismatched mouse model and investigated their immunomodulatory effects. Their results showed that non-cultured mouse DMSCs decreased the incidence and severity of acute GvHD during MHC-mismatched stem cell transplantation in mice. [Biomaterials] Abstract
For Feeder-Free Culture of Human ES Cells and iPS Cells
 
PUBLICATIONS (Ranked by impact factor of the journal)
Mesenchymal Stem Cells Induce Non-Classical IL-10-Producing Regulatory TH17 Cells in Arthritis: Role of Gilz
Scientists evaluated the molecular mechanisms involved in the therapeutic potential of mesenchymal stem cell (MSC) in a murine model of rheumatoid arthritis (RA) and to better understand how the immune balance between Th1/Th17 and Treg cells is regulated following MSC injection. They focused their study on the role of Gilz which was recently described as an inhibitor of immune-inflammatory responses in RA. [Ann Rheum Dis] Abstract

Engineering of Pre-Vascularized Urethral Patch with Muscle Flaps and Hypoxia-Activated hUCMSCs Improves Its Therapeutic Outcome
In this study, with the assistance of hypoxia-activated human umbilical cord mesenchymal stem cells (hUCMSCs), pedicled muscle flaps were used as materials and pre-incubated in ventral penile subcutaneous cavity of rabbit for 3 weeks to prepare a pre-vascularized urethral construct. [J Cell Mol Med] Abstract

Mouse Flk-1+Sca-1- Mesenchymal Stem Cells: Functional Plasticity In Vitro and Immunoregulation In Vivo
Researchers isolated Flk-1+Sca-1 mesenchymal stem cells (MSCs) from bone marrow and studied their biological characteristics and immunologic functions. They also investigated their effects on graft-versus-host disease associated with allogeneic bone marrow transplantation in mice. [Transplantation] Abstract

Heterogeneity of Baseline Neural Marker Expression by Undifferentiated Mesenchymal Stem Cells May Be Correlated to Donor Age
Researchers showed that amongst a mixed group of primary adipose and bone marrow-derived mesenchymal stem cells(12–50 years), the observed variability in baseline neural marker expression may be correlated to donor age. [J Biotechnol] Abstract

Overexpression of Wnt11 Promotes Chondrogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells in Synergism with TGF-β
Scientists investigated the role of Wnt11, a member of noncanonical Wnts, in mesenchymal stem cells (MSCs) during chondrogenic differentiation. They observed that overexpression of Wnt11 inhibited proliferation of MSCs and caused a G0/G1 cell cycle arrest. [Mol Cell Biochem] Abstract

Mesenchymal Stem Cells Support Hepatocyte Function in Engineered Liver Grafts
The authors describe enhanced hepatic function achieved using a strategy of sequential infusion of cells and illustrate the advantages of co-cultivating bone marrow-derived mesenchymal stem cells with primary hepatocytes in the engineered whole-liver scaffold. [Organogenesis] Abstract

A Combinatorial Cell-Laden Gel Microarray for Inducing Osteogenic Differentiation of Human Mesenchymal Stem Cells
Development of three dimensional (3D) microenvironments that direct stem cell differentiation into functional cell types remains a major challenge in the field of regenerative medicine. Investigators describe a new platform to address this challenge by utilizing a robotic microarray spotter for testing stem cell fates inside various miniaturized cell-laden gels in a systematic manner. To demonstrate the feasibility of their platform, they evaluated the osteogenic differentiation of human mesenchymal stem cells within combinatorial 3D niches. [Sci Rep] Full Article

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View Technical Data: Superior Chondrogenic Differentiation Potential of MesenCult-XF Cultured MSCs
 
REVIEWS
Bone Marrow Mesenchymal Stem Cells and TGF-β Signaling in Bone Remodeling
The spatiotemporal release and activation of matrix TGF-β during osteoclast bone resorption recruits mesenchymal stem cells (MSCs) to bone-resorptive sites. Dysregulation of TGF-β alters MSC fate, uncoupling bone remodeling and causing skeletal disorders. Modulation of TGF-β or parathyroid hormone signaling may reestablish coupled bone remodeling and be a potential therapy. [J Clin Invest] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.
 
INDUSTRY NEWS
Experienced Stem Cell Product Developer to Join Cynata
Cynata Therapeutics Ltd announced the appointment of Dr. Kilian Kelly as Vice President, Product Development. Dr. Kelly will be a member of Cynata’s executive management team and will lead the regulatory, pre-clinical and clinical development of the Company’s proprietary Cymerus™ mesenchymal stem cell product pipeline. [Cynata Therapeutics Ltd] Press Release

BrainStorm Receives US Notice of Allowance for Its Key Stem Cell Technology Patent
BrainStorm Cell Therapeutics announced that it has received a Notice of Allowance from the U.S. Patent Office for its “Mesenchymal Stem Cells for the Treatment of CNS Diseases” patent application. This patent relates to BrainStorm’s proprietary stem cells induced to secrete large quantities of neurotrophic factors for the treatment of neurodegenerative diseases. [BrainStorm Cell Therapeutics Inc.] Press Release

Positive Spinal Disc Repair Trial Results Using Mesoblast Adult Stem Cells
Regenerative medicine company Mesoblast Limited announced positive 12 month outcome results from the 100-patient Phase II clinical trial of its proprietary allogeneic, or “off-the-shelf”, Mesenchymal Precursor Cells (MPCs) in patients with chronic moderate to severe discogenic low back pain. [Mesoblast Limited] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW International Society for Stem Cell Research (ISSCR) 12th Annual Meeting
June 18-21, 2014
Vancouver, Canada

Visit our events page to see a complete list of events in the mesenchymal cell community.
 
JOB OPPORTUNITIES
NEW Fellowship – Mesenchymal Stem Cell-Derived Microvescicles and Pericyte Dysfunction in Diabetic Microangiopathy (University of Turin)

NEW Lab Technologist – Human Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Fellow – Mesenchymal Stem/Stromal Cell Biology (DRK-Blutspendedienst Baden-Württemberg-Hessen gGmbH)

Postdoctoral Researcher Position – Role of Muscle Stem Cells in Tissue Regeneration after Radiation Injury (IRSN [French Nuclear Safety Institute])

Postdoctoral Position – Regenerative Medicine (Centro Cardiologico Monzino IRCCS)

Postdoctoral Position – Cardiopulmonary Molecular Biology (Hannover Medical School)

Postdoctoral Position – Tissue Engineering and Regenerative Medicine (RUNMC)


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