Volume 6.06 | Feb18

Mesenchymal Cell News 6.06 February 18, 2014
Mesenchymal Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
The Effects of Actin Cytoskeleton Perturbation on Keratin Intermediate Filament Formation in Mesenchymal Stem/Stromal Cells
Scientists investigated differential gene expression and subsequent physiological changes in response to F-actin perturbation by latrunculin B in mesenchymal stem/stromal cells. Nineteen genes were down-regulated and 27 genes were up-regulated in the first 15 minutes after F-actin depolymerization. [Biomaterials] Abstract
Directed Differentiation of Pluripotent Stem Cells - A Cell Stem Cell Poster
 
PUBLICATIONS (Ranked by impact factor of the journal)
Galectin-1 Stimulates Motility of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells by Downregulation of Smad2/3-Dependent Collagen 3/5 and Upregulation of NF-κB-Dependent Fibronectin/Laminin 5 Expression
Scientists analyzed 17 extracellular matrix genes in umbilical cord blood-derived mesenchymal stem cells. Galectin-1 decreased the expression of collagen genes COL3A1 and COL5A1 but increased the expression of fibronectin and laminin 5, that were reversed by β-lactose. [Cell Death Dis] Full Article

Extracellular Calcium and CaSR Drive Osteoinduction in Mesenchymal Stromal Cells
The authors evaluated the roles of extracellular calcium ([Ca2+]o) and calcium sensing receptor (CaSR) in osteoinduction. Rat bone marrow mesenchymal stromal cells were stimulated with 10 mM of Ca2+. Several experiments were conducted to demonstrate the effect of [Ca2+]o on chemotaxis, proliferation and differentiation to the osteoblastic lineage. [Acta Biomater] Abstract

Reprogramming to a Pluripotent State Modifies Mesenchymal Stem Cell Resistance to Oxidative Stress
Researchers compared the response of induced pluripotent stem cells generated from menstrual blood-derived mesenchymal stem cells, embryonic stem cells and adult menstrual blood-derived mesenchymal stem cells to reactive oxygen exposure and investigate the effects of reprogramming on cellular oxidative stress. [J Cell Mol Med] Full Article

Mesenchymal Stem Cells Recruited by Active TGFβ Contribute to Osteogenic Vascular Calcification
Scientists used a low-density lipoprotein receptor-deficient mouse model, which develop progressively arterial calcification after fed high-fat Western diets, to examine whether TGFβ is involved in the mobilization of mesenchymal stem cells during vascular calcification. [Stem Cells Dev] Abstract

Transplantation of Bone Marrow Mesenchymal Stem Cells Decreases Oxidative Stress, Apoptosis, and Hippocampal Damage in Brain of a Spontaneous Stroke Model
The authors aimed to evaluate whether mesenchymal stem cells (MSCs) decrease apoptotic death and oxidative stress in existing stroke-prone spontaneously hypertensive rat brain tissue. The results of qRT-PCR assays showed higher levels of the antiapoptotic Bcl-2 gene in the MSC-treated animals, compared with untreated. [Free Radic Biol Med] Full Article

Mesenchymal Stem Cell Injection Protects against Oxidative Stress in Escherichia coli-Induced Acute Lung Injury in Mice
Investigators hypothesized that intravenous injection of bone marrow-derived mesenchymal stem cells (MSCs) could attenuate Escherichia coli-induced acute lung injury (ALI) in mice by controlling the oxidative stress status. Pre- and post-injury MSC injection increased survival, reduced pulmonary edema and attenuated lung injuries in ALI mice. [Cytotherapy] Abstract

The Involvement of CXCL11 in Bone Marrow-Derived Mesenchymal Stem Cell Migration through Human Brain Microvascular Endothelial Cells
Scientists modeled the interactions between human mesenchymal stem cells (hMSCs) and human brain microvascular endothelial cells (HBMECs) to mimic the blood-brain barrier microenvironment. Real-time PCR analysis indicated that the chemokine CXCL11 is produced by hMSCs and the chemokine receptor CXCR3 is expressed on HBMECs. [Neurochem Res] Abstract

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Achieve Superior Differentiation of Mouse MSC & MEF into Osteoblasts with the New MesenCult™ Osteogenic Stimulatory Kit (Mouse)
 
REVIEWS
Interferon-Gamma Modification of Mesenchymal Stem Cells: Implications of Autologous and Allogeneic Mesenchymal Stem Cell Therapy in Allotransplantation
The authors examine the potential benefits of mesenchymal stem cell (MSC) therapy in the context of allotransplantation. They also discuss the use of autologous and allogeneic MSC and the issues associated with their immunogenicity in vivo, with particular focus on the use of enhanced IFN-γ preactivated MSC cellular therapy. [Stem Cell Rev] Abstract

Cells of Origin in Osteosarcoma: Mesenchymal Stem Cells or Osteoblast Committed Cells?
As more information is gathered regarding osteosarcoma initiating cells and how they may relate to the cell of origin researchers will derive a better understanding of the development of osteosarcoma which may ultimately lead to clinical improvements through more personalized therapeutic approaches. [Bone] Abstract

Mesenchymal Stem Cell Trials for Pulmonary Diseases
This mini-review summarizes ongoing clinical trials using mesenchymal stem/stromal cells (MSC) in lung diseases, critically examine the data supporting their use for this purpose, and discuss the next steps in the translational pathway for MSC therapy of lung diseases. [J Cell Biochem] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

Attend ISCT 2014 in Paris, France!
 
INDUSTRY NEWS
Cynata Partners with Leading Biologic Product Manufacturer
Cynata Therapeutics Ltd announced that it has signed a manufacturing agreement with Waisman Biomanufacturing under which Waisman will undertake manufacturing process development, scale-up and clinical-grade manufacture of Cynata’s proprietary Cymerus™ off-the-shelf stem cell product. [Cynata Therapeutics Ltd] Press Release

Parcell Laboratories Promotes Colin White, Ph.D., to Chief Scientific Officer
Parcell Laboratories, Inc., developer of novel therapeutics based on its patented adult stem cell platform technology, the ELA® cell, has promoted Colin White, Ph.D., to the newly-created position of chief scientific officer. [Marketwire L.P.] Press Release

Ampio Announces Positive Preliminary Biochemical Findings from the Synovial Fluid of the Knees Treated in the SPRING Study
Ampio Pharmaceuticals, Inc. announced preliminary biochemical analysis of samples of synovial fluid drawn from the index knee (treated knee) of a subset of patients who participated in the SPRING study. This synovial analysis, suggested by the FDA, tests the change in expression of signaling and structural proteins that arise from the treatment of the knee with either AmpionTM or the saline vehicle control. [Ampio Pharmaceuticals Inc.] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW 5th International Conference on Stem Cells and Cancer (ICSCC-2014): Proliferation, Differentiation and Apoptosis
November 8-10, 2014
New Delhi, India

Visit our events page to see a complete list of events in the mesenchymal cell community.
 
JOB OPPORTUNITIES
NEW Cell Culture Specialist (Tisch MS Research Center of New York)

NEW Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

NEW Research Technologist – Particle Chemistry (STEMCELL Technologies Inc.)

NEW Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

Associate/Full Professor – Cardiovascular, Pulmonary, Neural Tissue Engineering/Regenerative Medicine (Temple University)

Postdoctoral Fellow – Regenerative Biology (University of California San Francisco)

Research Fellow – Mesenchymal Stem/Stromal Cell Biology (DRK-Blutspendedienst Baden-Württemberg-Hessen gGmbH)

Postdoctoral Researcher Position – Role of Muscle Stem Cells in Tissue Regeneration after Radiation Injury (IRSN [French Nuclear Safety Institute])

Postdoctoral Position – Regenerative Medicine (Centro Cardiologico Monzino IRCCS)

Postdoctoral Position – Cardiopulmonary Molecular Biology (Hannover Medical School)


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