Volume 6.07 | Feb 25

Mesenchymal Cell News 6.07 February 25, 2014
Mesenchymal Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Researchers Show Nuclear Stiffness Keeps Stem Cells and Cancer Cells in Place
Researchers have shown that cell migration through micron-size pores is regulated by lamin-A, a nuclear protein that is very similar to the fibrous ones that make up hair. The study’s experiments were conducted on immortalized human cancer cells as well as human-donor-derived mesenchymal stem cells. [Press release from the University of Pennsylvania discussing online prepublication in the Journal of Cell Biology]
Press Release | Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Cytotoxic CD8+ T Cells Stimulate Hematopoietic Progenitors by Promoting Cytokine Release from Bone Marrow Mesenchymal Stromal Cells
Researchers indicated that during an acute viral infection, cytotoxic CD8+ T cells indirectly modulate early multipotent hematopoietic progenitors via mesenchymal stromal cells in order to trigger the temporary activation of emergency myelopoiesis and promote clearance of the infection. [Cell Stem Cell]
Abstract | Graphical Abstract

Scaffold-Mediated Lentiviral Transduction for Functional Tissue Engineering of Cartilage
Scientists showed that poly-L-lysine could immobilize lentivirus to poly(e-caprolactone) films and facilitate human mesenchymal stem cell (hMSC) transduction. They then demonstrated that scaffold-mediated gene delivery of transforming growth factor ß3, using a 3D woven poly(e-caprolactone) scaffold, induced robust cartilaginous extracellular matrix formation by hMSCs. [Proc Natl Acad Sci USA] Abstract | Press Release

miR-142-3p Balances Proliferation and Differentiation of Mesenchymal Cells during Lung Development
Investigators determined that miR-142-3p contributes to the proper proliferation of mesenchymal progenitors by controlling the level of WNT signaling. [Development] Abstract

Low-Intensity Pulsed Ultrasound (LIPUS) Influences the Multi-Lineage Differentiation of Mesenchymal Stem and Progenitor Cell Lines through ROCK-Cot/Tpl2-MEK-ERK Signaling Pathway
Researchers applied LIPUS to adipogenic progenitor cell and mesenchymal stem cell lines to analyze how multi-lineage cell differentiation was affected. [J Biol Chem] Abstract | Full Article

Chondrogenically Differentiated Mesenchymal Stromal Cell Pellets Stimulate Endochondral Bone Regeneration in Critical-Sized Bone Defects
Researchers determined if chondrogenically differentiated mesenchymal stromal cells pellets could induce bone regeneration in an orthotopic environment through endochondral ossification. [Eur Cell Mater] Abstract

Cellular Reporter Systems for High-Throughput-Screening of Interactions between Bioactive Matrices and Human Mesenchymal Stromal Cells
Researchers aimed at the identification of extracellular matrix components and candidate morphogens capable of enhancing the expression of hematopoietic stem cell-supportive proteins in human mesenchymal stromal cells, namely Angiopoietin-1 and stromal cell-derived factor 1. [Tissue Eng Part C Methods] Abstract

Comparisons of Rabbit Bone Marrow Mesenchymal Stem Cell Isolation and Culture Methods In Vitro
Isolated bone marrow mesenchymal stem cells were evaluated with respect to primary cell yield, number of CFU-F colonies, proliferative capacity, cell phenotype, and chondrogenic differentiation potential. [PLoS One] Full Article

Umbilical Cord-Derived Mesenchymal Stem Cells Regulate Thymic Epithelial Cell Development and Function in Foxn1-/- Mice
Scientists used human umbilical cord-derived mesenchymal stem cells to treat forkhead box n1 (Foxn1)-/- mice, and then analyzed the maturation and distribution of thymic epithelial cells in the Foxn1-/- thymic rudiment and the thymopoiesis of this newly developed rudiment. [Cell Mol Immunol] Abstract

Adipose Stem Cells Used to Reconstruct 13 Cases with Cranio-Maxillofacial Hard-Tissue Defects
Autologous adipose tissue was harvested from the anterior abdominal wall, and adipose-derived stem cells were cultured, expanded, and then seeded onto resorbable scaffold materials for subsequent reimplantation into hard-tissue defects. [Stem Cells Transl Med] Abstract

Mesenchymal Stem Cells with Modification of Junctional Adhesion Molecule A Induce Hair Formation
Scientists used human junctional adhesion molecule A-modified human mesenchymal stem cells to repair hair follicle abnormalities in BALB/c nu/nu mice. [Stem Cells Transl Med] Abstract

Learn How to Assemble & Purge the Hypoxia Chamber Watch the Video
 
REVIEWS
Mesenchymal Stem Cells: Immune Evasive, Not Immune Privileged
Mesenchymal stem/stromal cells (MSCs) have long been reported to be hypoimmunogenic or ‘immune privileged’; this property is thought to enable MSC transplantation across major histocompatibility barriers and the creation of off-the-shelf therapies consisting of MSCs grown in culture. However, recent studies describing generation of antibodies against and immune rejection of allogeneic donor MSCs suggest that MSCs may not actually be immune privileged. [Nat Biotech] Abstract

Umbilical Cord Mesenchymal Stem Cells: The New Gold Standard for Mesenchymal Stem Cell Based Therapies?
In this review, the authors aimed to synthesize the differences between umbilical cord-mesenchymal stromal cells (MSCs) and MSCs from other sources (bone marrow, adipose tissue, periodontal ligament, dental pulp,…) concerning their proliferation capacity, proteic and transcriptomic profiles and their secretome involved in their regenerative, homing and immunomodulatory capacities. [Tissue Eng Part B Rev] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.
 
INDUSTRY NEWS
Key European Patent Granted for Use of Mesoblast’s Mesenchymal Precursor Cells in Cardiac and Vascular Conditions
The granted patent covers the use of Mesoblast’s allogeneic or ‘off-the-shelf’ mesenchymal precursor cells for cardiac and vascular conditions, including acute myocardial infarction, congestive heart failure, angina, peripheral arterial disease, and cerebrovascular stroke. [Mesoblast Limited] Press Release

Pluristem Receives Key 3D Cell Expansion Patent in Australia
Pluristem Therapeutics, Inc. announced it has been granted a new patent by the Australian Patent Office. Patent #2007228341 covers the method and composition of matter for three-dimensional expansion of placental or adipose (fat) stromal cells, Pluristem’s key technology platform. [Pluristem Therapeutics, Inc.]
Press Release

New Phase IIa Trial in the United States and Phase III Trial in Kazakhstan Study the Use of CardioCell’s Ischemia-Tolerant Mysenchymal Stem Cells Therapy for Treating Acute Myocardial Infarction
CardioCell LLC announced two new clinical trials using its allogeneic stem-cell therapy to treat subjects with acute myocardial infarction, a problem facing more than 1.26 million Americans annually. [CardioCell LLC]
Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Stem Cells and Regenerative Medicines Congress Asia
October 21-23, 2014
Seoul, Korea

NEW Cell Culture World Congress Asia
October 21-23, 2014
Seoul, Korea

Visit our events page to see a complete list of events in the mesenchymal cell community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Research Assistant – Functional Hybrid Bionanomaterials (University of Bristol)

NEW PhD Studentship – Stem Cell Research (University Medical Center Ulm)

Cell Culture Specialist (Tisch MS Research Center of New York)

Associate/Full Professor – Cardiovascular, Pulmonary, Neural Tissue Engineering/Regenerative Medicine (Temple University)

Postdoctoral Fellow – Regenerative Biology (University of California San Francisco)

Research Fellow – Mesenchymal Stem/Stromal Cell Biology (DRK-Blutspendedienst Baden-Württemberg-Hessen gGmbH)

Postdoctoral Researcher Position – Role of Muscle Stem Cells in Tissue Regeneration after Radiation Injury (IRSN [French Nuclear Safety Institute])

Postdoctoral Position – Regenerative Medicine (Centro Cardiologico Monzino IRCCS)

Postdoctoral Position – Cardiopulmonary Molecular Biology (Hannover Medical School)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)


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