Volume 6.10 | Mar 18

Mesenchymal Cell News 6.10 March 18, 2014
Mesenchymal Cell News
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Mechanical Memory and Dosing Influence Stem Cell Fate
Researchers found that the activation of the Yes-associated protein and transcriptional coactivator with PDZ-binding domain as well as the pre-osteogenic transcription factor RUNX2 in human mesenchymal stem cells cultured on soft poly(ethylene glycol) hydrogels depended on previous culture time on stiff tissue culture polystyrene. [Nat Mater] Abstract | Editorial
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PUBLICATIONS (Ranked by impact factor of the journal)
Comparative Analysis of Mouse Induced Pluripotent Stem Cells and Mesenchymal Stem Cells during Osteogenic Differentiation In Vitro
Scientists provide a direct in vitro comparison of the osteogenic differentiation process in mesenchymal stem cells and induced pluripotent stem cells from adult C57BL/6J mice. [Stem Cells Dev] Abstract

Functional Comparison of Human Induced Pluripotent Stem Cell-Derived Mesenchymal Cells and Bone Marrow-Derived Mesenchymal Stromal Cells from the Same Donor
Scientists have derived mesenchymal stem cell-like cells (iMPCs) using four different methodologies from a newly established induced pluripotent stem cell line reprogrammed from human bone marrow stromal cells (BMSCs), and compared the iMPCs directly to the originating parental BMSCs. [Stem Cells Dev] Abstract

Development of a Dynamic Stem Cell Culture Platform for Mesenchymal Stem Cell Adhesion and Evaluation
The authors have developed a device, the dynamic stem cell culture platform, consisting of a biomimetic scaffold cultured within the dynamic environment of a perfusion bioreactor. By varying scaffold parameters including stiffness and protein inclusion at the material surface, they found that mesenchymal stem cells were able to adhere to modified substrates, while still maintaining multipotency. [Mol Pharm] Abstract

Growth Differentiation Factor 6 and Transforming Growth Factor-Beta Differentially Mediate Mesenchymal Stem Cell Differentiation, Composition and Micromechanical Properties of Nucleus Pulposus Constructs
Researchers investigated the effect of growth differentiation factor-6, compared to other transforming growth factor superfamily members, on discogenic differentiation of mesenchymal stem cells, the matrix composition and micromechanics of engineered nucleus pulposus tissue constructs. [Arthritis Res Ther]
Abstract | Full Article

Nanotopography Directs Mesenchymal Stem Cells to Osteoblast Lineage through Regulation of MicroRNA-SMAD-BMP-2 Circuit
Researchers investigated if chemically produced nanotopography on titanium surface induces osteoblast differentiation of cultured human bone marrow mesenchymal stem cells by regulating the expression of microRNAs. [J Cell Physiol] Abstract

Mesenchymal Stem Cell or Chondrocyte Seeded Microcarriers as Building Blocks for Cartilage Tissue Engineering
Researchers tested the use of mesenchymal stromal/stem cell- or chondrocyte laden microcarriers as building blocks for engineered cartilage tissue. [Tissue Eng Part A] Abstract

Biochemical and Structural Characterization of Neocartilage Formed by Mesenchymal Stem Cells in Alginate Hydrogels
Investigators focused on mesenchymal stem cells immobilized in alginate hydrogels, and used immunohistochemistry and gene expression analysis combined with advanced microscopy techniques to describe properties of cells and distribution and organization of the forming extracellular matrix. [PLoS One]
Full Article

Cell-Autonomous Heparanase Modulates Self-Renewal and Migration in Bone Marrow-Derived Mesenchymal Stem Cells
Scientists inhibited the enzymatic activity of cell-autonomous heparanase (HPSE1) in bone marrow-derived mesenchymal stem cells to clarify the physiological role of HPSE1 in bone marrow-derived mesenchymal stem cells. [J Biomed Sci] Abstract

IKVAV Regulates ERK1/2 and Akt Signaling Pathways in BMMSC Population Growth and Proliferation
The molecular mechanism of bone marrow mesenchymal stem cell (BMMSC) population growth and proliferation, induced by Isoleucyl-lysyl-valyl-alanyl-valine (IKVAV), was explored in this study. [Cell Prolif]
Full Article

Cell-Penetrating Peptide (CPP)-Conjugated Proteins Is an Efficient Tool for Manipulation of Human Mesenchymal Stromal Cells
Researchers performed a comparison study of CPP-conjugated protein delivery systems using seven arginine and Streptolysin O-mediated systems. [Sci Rep] Full Article

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Mesenchymal Stem Cells, Cancer Challenges and New Directions
The authors focus on the therapeutic potential of the human mesenchymal stem cells (hMSC) with special focus on their use in cancer therapy. They consider different mechanisms, by which stem cells can maintain telomeres and thereby the cell’s ability to be expanded in vitro, and also focus on a new therapeutic venue that utilizes hMSCs as delivery vehicles in innovative new cancer treatments. [Eur J Cancer] Abstract

Significance of Epigenetic Landscape in Cartilage Regeneration from the Cartilage Development and Pathology Perspective
The authors compiled and reorganized the existing literature pertaining to epigenetic remodeling events placing emphasis on perceiving the landscape of epigenetic mechanisms during cartilage regeneration with the new operational definition, especially from the environmental factors’ point of view. [Stem Cells Dev] Abstract

Exosomes Derived from Mesenchymal Stem Cells
Compared with cells, exosomes are more stable and reservable, have no risk of aneuploidy, a lower possibility of immune rejection following in vivo allogeneic administration, and may provide an alternative therapy for various diseases. In this review, the authors summarize the properties and biological functions of mesenchymal stem cell-derived exosomes and discuss the related mechanisms. [Int J Mol Sci] Abstract | Download Full Article

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.
Stem Cell Therapy May Help Severe Congestive Heart Failure
A multi-site study is being conducted, in which stem cells are removed from the bone marrow, their numbers significantly increased by technology developed by Aastrom Biosciences, then injected into multiple weak points in the heart. [Medical College of Georgia at Georgia Regents University] Press Release

AIM Receives $1 Million Gift to Advance Stem Cell Research
Inaugurating a new era of philanthropic giving for stem cell research in Alabama, the Alabama Institute of Medicine (AIM) announced the generous donation of $1 Million dollars from an anonymous Birmingham resident. [Alabama Institute of Medicine] Press Release

STEMSOFT Announces Release of New BMT Clinic Software Solution
STEMSOFT™ Software Inc. announced the release of a new BMT cellular therapy transplant software solution, STEMSOFT CLINIC. This new system efficiently manages all patient and donor information in one location complete with an available BMT registry submission and retrieval process for all available forms using the CIBMTR AGNIS system. [STEMSOFT™ Software Inc.] Press Release

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Alliance for Regenerative Medicine Announces Introduction of Regenerative Medicine Promotion Act of 2014 in the Senate
The Alliance for Regenerative Medicine announced the introduction of the Regenerative Medicine Promotion Act of 2014 in the U.S. Senate and expressed appreciation for the efforts of its lead sponsors, Senators Barbara Boxer and Mark Kirk. [Alliance for Regenerative Medicine] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Tissue Engineering Congress 2014
June 2-4, 2014
London, United Kingdom

Visit our events page to see a complete list of events in the mesenchymal cell community.
NEW Postdoctoral Position – Cardiopulmonary Molecular Biology (Hannover Medical School)

Postdoctoral Associate – Cardiac Repair Mechanisms of Mesenchymal Stem Cells and Cardiac Stem Cells (University of Miami)

Postdoctoral Position – Mesenchymal Stem Cells (University of South Australia)

Director of GMP/GLP Quality Operations (University of Pennsylvania, Perelman School of Medicine)

Postdoctoral Research Assistant – Functional Hybrid Bionanomaterials (University of Bristol)

Cell Culture Specialist (Tisch MS Research Center of New York)

Associate/Full Professor – Cardiovascular, Pulmonary, Neural Tissue Engineering/Regenerative Medicine (Temple University)

Research Fellow – Mesenchymal Stem/Stromal Cell Biology (DRK-Blutspendedienst Baden-Württemberg-Hessen gGmbH)

Scientific Communications & Publishing Coordinator (STEMCELL Technologies, Inc.)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

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