Volume 6.11 | Mar 25

Mesenchymal Cell News 6.11 March 25, 2014
Mesenchymal Cell News
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Inhibition of Akt/mTOR Attenuates Age-Related Changes in Mesenchymal Stem Cells
Researchers showed that blocking of PI3K/Akt/mTOR prevents the development of an age related phenotype and maintains mesenchymal stem cell morphology of early passage cells with high clonogenic frequency and enhanced proliferative capacity. [Stem Cells] Abstract
Achieve Superior Differentiation of Mouse MSC & MEF into Osteoblasts with the New MesenCultâ„¢ Osteogenic Stimulatory Kit (Mouse)
PUBLICATIONS (Ranked by impact factor of the journal)
MiR-335 Correlates with Senescence/Aging in Human Mesenchymal Stem Cells and Inhibits Their Therapeutic Actions through Inhibition of AP-1 Activity
Scientists investigated the significance of microRNA (miR)-335 for the therapeutic potential of human mesenchymal stem cells (hMSCs). Analysis of hMSCs in ex vivo culture demonstrated a significant and progressive increase in miR-335 that is prevented by telomerase. [Stem Cells] Abstract

Mesenchymal Stem Cell Population Derived from Human Pluripotent Stem Cells Displays Potent Immunomodulatory and Therapeutic Properties
Researchers utilized a developmental precursor called the hemangioblast as an intermediate cell type in the derivation of a highly potent and replenishable population of mesenchymal stem cells from human embryonic stem cells. [Stem Cells Dev] Abstract | Full Article | Press Release

Salvianolic Acid B Promotes Osteogenesis of Human Mesenchymal Stem Cells through Activating ERK Signaling Pathway
Researchers investigated the effects of Salvianolic acid B on viability and osteogenic differentiation of human mesenchymal stem cells. [Int J Biochem Cell Biol] Abstract

A Multi-Compartment Holder for Spinner Flasks Improves Expansion and Osteogenic Differentiation of Mesenchymal Stem Cells in 3D Scaffolds
Researchers designed a multi-compartment holder for three-dimensional (3D) cell culture, easily adaptable to spinner flasks. Here, the device was tested with human mesenchymal stem cells seeded in 3D porous chitosan scaffolds that were maintained in spinner flasks under dynamic conditions. [Tissue Eng] Abstract

Mesenchymal Stem Cells Modulate Albumin-Induced Renal Tubular Inflammation and Fibrosis
Using a co-culture model of human proximal tubular epithelial cells (PTECs) and bone marrow-derived mesenchymal stem cells (BM-MSCs), scientists showed that concomitant stimulation of BM-MSCs by albumin excess was a prerequisite for them to attenuate albumin-induced IL-6, IL-8, TNF-a, CCL-2, CCL-5 overexpression in PTECs, which was partly mediated via deactivation of tubular NF-?B signaling. [PLoS One] Full Article

Comparison of Articular Cartilage Repair with Different Hydrogel-Human Umbilical Cord Blood-Derived Mesenchymal Stem Cell Composites in a Rat Model
Investigators explored the feasibility and efficacy of articular cartilage repair using composites of human umbilical cord blood derived mesenchymal stem cells and four different hydrogels in a rat model. [Stem Cells Res Ther] Abstract | Full Article

Can Arthroscopically Harvested Synovial Stem Cells Be Preferentially Sorted Using Stage-Specific Embryonic Antigen 4 Antibody for Cartilage, Bone, and Adipose Regeneration?
Researchers investigated the relation between stage-specific embryonic antigen 4 expression and synovium-derived stem cell lineage differentiation. [Arthroscopy] Abstract

Surface Modification on Polycaprolactone Electrospun Mesh and Human Decalcified Bone Scaffold with Synovium-Derived Mesenchymal Stem Cells Affinity Peptide for Tissue Engineering
Investigators identified a seven amino acid peptide sequence through phage display technology that has a high specific affinity to synovium-derived mesenchymal stem cells. [J Biomed Mater Res A] Abstract

Characterization and In Vitro Differentiation Potency of Early-Passage Canine Amnion- and Umbilical Cord-Derived Mesenchymal Stem Cells as Related to Gestational Age
Scientists cytogenetically and molecularly characterized and followed the in vitro proliferation and differentiation potential of early-passage canine amniotic membrane mesenchymal stem cells (MSCs) and umbilical cord matrix MSCs isolated from fetuses at early and late gestational ages. [Mol Reprod Dev] Abstract

Characterization of Mesenchymal Stem Cells under the Stimulation of Toll-Like Receptor Agonists
Scientists demonstrated that mesenchymal stem cells express functional Toll-like receptors 3 and 4, the Toll-like receptor families that recognize the signals of viral and bacterial mimics, respectively. [Dev Growth Differ] Abstract

Overexpression of Stearoyl-CoA Desaturase 1 in Bone Marrow Mesenchymal Stem Cells Enhance the Expression of Induced Endothelial Cells
Researchers studied the relationship between overexpression of stearoyl-CoA desaturase 1 and the expression of induced endothelial cells in bone marrow mesenchymal stem cells in vitro. [Lipids Health Dis]
Abstract | Full Article

Enter to Win a Travel Award to ISSCR 2014
Mechanisms of Tumor Escape from Immune System: Role of Mesenchymal Stromal Cells
Evidence points out the role of mesenchymal stromal cells (MSC), both in epithelial solid tumors and hematological malignancies, in regulating tumor cell growth and immune response. The authors review this evidence and suggest that MSC can be a suitable target for a more efficient anti-tumor therapy. [Immunol Lett] Abstract

Novel Approaches to Lupus Drug Discovery Using Stem Cell Therapy. Role of Mesenchymal-Stem-Cell-Secreted Factors
The authors highlight the data on mesenchymal stem cell (MSC) treatment of systemic lupus erythematosus and related mechanisms of actions. This data includes the recent evidence that MSC-secreted factors such as extracellular microvesicles are important mediators of MSC therapy. [Expert Opin Drug Discov] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.
Pioneering Stem Cell Therapies to Be Trialed in Birmingham
University of Birmingham researchers are to lead a worldwide collaboration of scientists looking at the possibility of transplanting stem cells from one person to another to reduce inflammation in the liver. [University of Birmingham] Press Release

IntelliCell Biosciences Announces that it Is Collaborating with the Global Alliance for Innovation in Neuroscience, Inc. (GAIN) for Autism, Dementia and Brain Trauma
IntelliCell Biosciences, Inc. announced that it will be entering into a collaboration with GAIN to use its unique approach to the harvest and use of autologous adipose derived mesenchymal stem cells for clinical neuroscience applications including autism, dementia and brain trauma. [Marketwire L.P.] Press Release

Cellular Biomedicine Group Launches Development Program for Asthma Stem Cell Therapy
Cellular Biomedicine Group Inc. announced the launch of their pre-clinical study on human adipose derived mesenchymal progenitor cell (haMPC) therapy for asthma. The study will evaluate the safety and efficacy of haMPCs to treat severe asthma. [GlobeNewswire, Inc.] Press Release

Independent Sports Medicine Study Using Cytori Cell Therapy to Treat ACL Injury Underway in Spain
Cytori Therapeutics announced the first investigator-initiated study evaluating Cytori Cell Therapy as a potential concomitant treatment for Anterior-cruciate ligament (ACL) injury. [Cytori Therapeutics] Press Release

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June 4, 2014
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Visit our events page to see a complete list of events in the mesenchymal cell community.
NEW PhD Student – Stem Cell Biology and Replicative Senescence (RWTH Aachen University Medical School)

Postdoctoral Position – Cardiopulmonary Molecular Biology (Hannover Medical School)

Postdoctoral Associate – Cardiac Repair Mechanisms of Mesenchymal Stem Cells and Cardiac Stem Cells (University of Miami)

Postdoctoral Position – Mesenchymal Stem Cells (University of South Australia)

Director of GMP/GLP Quality Operations (University of Pennsylvania, Perelman School of Medicine)

Cell Culture Specialist (Tisch MS Research Center of New York)

Associate/Full Professor – Cardiovascular, Pulmonary, Neural Tissue Engineering/Regenerative Medicine (Temple University)

Scientific Communications & Publishing Coordinator (STEMCELL Technologies, Inc.)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

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