Volume 6.12 | Apr 1

Mesenchymal Cell News 6.12 April 1, 2014
Mesenchymal Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Mesenchymal Precursor Cells as Adjunctive Therapy in Recipients of Contemporary LVADs
Allogeneic mesenchymal precursor cells injected during left ventricular assist device (LVAD) implantation may contribute to myocardial recovery. Investigators explored the safety and efficacy of this strategy. [Circulation] Abstract
Request Your Free Wallchart: Mesenchymal Stem Cells (A Nature Reviews Molecular Cell Biology Collaboration)
 
PUBLICATIONS (Ranked by impact factor of the journal)
The Effects of Graphene Nanostructures on Mesenchymal Stem Cells
Researchers report the effects of two-dimensional graphene nanostructures; graphene nano-onions, graphene oxide nanoribbons, and graphene oxide nanoplatelets on viability, and differentiation of human mesenchymal stem cells. [Biomaterials] Abstract | Video

Regeneration of Human-Ear-Shaped Cartilage by Co-Culturing Human Microtia Chondrocytes with BMSCs
Scientists demonstrated that microtia chondrocytes (MCs) possessed strong proliferation ability but accompanied with rapid loss of chondrogenic ability during passage, indicating a poor feasibility to engineer the entire ear using expanded MCs. [Biomaterials] Abstract

Hepatocyte Growth Factor and p38 Promote Osteogenic Differentiation of Human Mesenchymal Stem Cells
Researchers report that hepatocyte growth factor promotes osteogenic differentiation through the transcription of key osteogenic markers, including Osteocalcin, Osterix, and Osteoprotegerin in human mesenchymal stem cells and is a necessary component for the establishment of osteoblast mineralization. [Mol Endocrinol] Abstract

Osteogenesis from Human Induced Pluripotent Stem Cells: an In Vitro and In Vivo Comparison with Mesenchymal Stem Cells
Osteo-induced human induced pluripotent stem cells were implanted on the critical-size calvarial defects and long bone segmental defects in rats. The healing of defects was evaluated after 8 weeks and 12 weeks of implantation respectively. [Stem Cells Dev] Abstract

Generation of 3D Functional Microvascular Networks with Human Mesenchymal Stem Cells in Microfluidic Systems
Scientists investigated the role played by two endothelium-related molecules, angiopoietin and transforming growth factor, on bone marrow-derived human mesenchymal stem cell phenotypic transition toward a mural cell lineage, both in monoculture and in direct contact with human endothelial cells, within 3D fibrin gels in microfluidic devices. [Integr Biol] Abstract

Taurine Promotes Human Mesenchymal Stem Cells to Differentiate into Osteoblast through the ERK Pathway
Investigators showed that taurine increased the alkaline phosphatase activity and mineralized nodules in human mesenchymal stem cells induced by osteogenic induced medium. [Amino Acids] Abstract

Multipotential Stromal Cell Abundance in Cellular Bone Allograft: Comparison with Fresh Age-Matched Iliac Crest Bone and Bone Marrow Aspirate
Scientists enumerated and characterized multipotential stromal cells in a cellular bone allograft and compare with fresh age-matched iliac crest bone and bone marrow aspirate. [Regen Med] Full Article

Repeated Lipopolysaccharide Stimulation Promotes Cellular Senescence in Human Dental Pulp Stem Cells (DPSCs)
DPSCs were stimulated with lipopolysaccharide and senescence was evaluated by senescence-associated ß-galactosidase staining, with cell number and cell-cycle arrest being examined by BrdU assay and flow cytometry, respectively. [Cell Tissue Res] Abstract

Epigallocatechin-3-Gallate (EGCG) as a Pro-Osteogenic Agent to Enhance Osteogenic Differentiation of Mesenchymal Stem Cells from Human Bone Marrow: An In Vitro Study
The osteogenic effects of EGCG were studied in primary human bone-marrow-derived mesenchymal stem cells by detecting cell proliferation, alkaline phosphatase activity and the expression of relevant osteogenic markers. [Cell Tissue Res] Abstract

Estrogen as a Novel Agent for Induction of Adipose-Derived Mesenchymal Stem Cells for Osteogenic Differentiation: In Vivo Bone Tissue-Engineering Study
Scientists investigated whether the in vivo osteogenic differentiation potential of adipose-derived mesenchymal stem cells is enhanced by 17ß-estradiol. [Plast Reconstr Surg] Abstract

Learn How to Assemble & Purge the Hypoxia Chamber Watch the Video
 
REVIEWS
Human Bone Marrow Mesenchymal Progenitors: Perspectives on an Optimized In Vitro Manipulation
The authors propose and recommend a few procedures to be followed to facilitate the establishment of quality control standards when working with mesenchymal progenitors isolation and expansion. [Front Cell Dev Bio] Full Article

Concise Review: Optimizing Expansion of Bone Marrow Mesenchymal Stem/Stromal Cells for Clinical Applications
The authors explore how modulations in the two-dimensional paradigm affect mesenchymal stem/stromal cells progenitor properties and to highlight recent efforts in alternative expansion techniques. [Stem Cells Transl Med] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.
 
INDUSTRY NEWS
NUI Galway Researchers Encouraged by Positive Results on New Osteoarthritis Treatment
NUI Galway researchers are part of an EU-funded project looking at how stem cells from adult fat tissue could be used to activate the regeneration of cartilage. If successful, their work could lead to effective new treatments for millions of osteoarthritis sufferers. [NUI Galway] Press Release

£3.5 Million Boost for Regenerative Medicine Research Programs
The Loughborough University-led Centre for Doctoral Training (CDT) in Regenerative Medicine has been awarded £3.5 million from the Engineering and Physical Sciences Research Council and the Medical Research Council to further its research programs in this globally important and fast-growing field of the healthcare industry. [Loughborough University] Press Release

From our sponsor: Learn about assays for cord blood. Download the free technical bulletin.
 
POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW NYSTEM 2014 Meeting
May 29-30, 2014
New York, United States

Visit our events page to see a complete list of events in the mesenchymal cell community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Fellow – Regenerative Medicine (University of California, San Francisco)

NEW Research Associate – Cell Separation (STEMCELL Technologies Inc.)

PhD Student – Stem Cell Biology and Replicative Senescence (RWTH Aachen University Medical School)

Postdoctoral Position – Cardiopulmonary Molecular Biology (Hannover Medical School)

Postdoctoral Associate – Cardiac Repair Mechanisms of Mesenchymal Stem Cells and Cardiac Stem Cells (University of Miami)

Director of GMP/GLP Quality Operations (University of Pennsylvania, Perelman School of Medicine)

Cell Culture Specialist (Tisch MS Research Center of New York)

Associate/Full Professor – Cardiovascular, Pulmonary, Neural Tissue Engineering/Regenerative Medicine (Temple University)

Scientific Communications & Publishing Coordinator (STEMCELL Technologies, Inc.)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)


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