Volume 6.15 | Apr 22

Mesenchymal Cell News 6.15 April 22, 2014
Mesenchymal Cell News
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Researchers Transplant Regenerated Esophagus
Tissue engineering has been used to construct natural esophagi, which in combination with bone marrow stem cells have been safely and effectively transplanted in rats. The study showed that the transplanted organs remain patent and display regeneration of nerves, muscles, epithelial cells and blood vessels. [Press release from Karolinska Institutet discussing online prepublication in Nature Communications] Press Release | Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Mesenchymal Stem Cells Reduce Intervertebral Disc Fibrosis and Facilitate Repair
Scientists showed that the presence of mesenchymal stem cells can suppress abnormal deposition of collagen I in the nucleus pulposus, modulating profibrotic mediators MMP12 and HSP47, thus reducing collagen aggregation and maintaining proper fibrillar properties and function. [Stem Cells] Abstract

Identification and Characterization of PDGFRa+ Mesenchymal Progenitors in Human Skeletal Muscle
Researchers previously identified non-myogenic mesenchymal progenitors that contribute to adipogenesis and fibrogenesis in mouse skeletal muscle. In this study, they report the identification and characterization of a human counterpart to these progenitors. [Cell Death Dis] Full Article

Cadherin-11 Regulates Mesenchymal Stem Cell Differentiation into Smooth Muscle Cells and Development of Contractile Function In Vivo
Scientists found that Cadherin-11 but not Cadherin-2 was necessary for mesenchymal stem cell differentiation into smooth muscle cells (SMCs). Cadherin-11 regulated expression of transforming growth factor (TGF)-ß1 and affected SMC differentiation through a TGF-ß receptor II dependent but Smad2/3 independent pathway. [J Cell Sci] Abstract

Netrin-1 Induces MMP-12-Dependent E-Cadherin Degradation via the Distinct Activation of PKCa and FAK/Fyn in Promoting Mesenchymal Stem Cells Motility
Researchers investigated the role of netrin-1 in promoting the motility of human umbilical cord blood derived mesenchymal stem cells and its related signaling pathways. [Stem Cells Dev] Abstract

Mitochondrial Transfer of Induced Pluripotent Stem Cells-Derived MSCs to Airway Epithelial Cells Attenuates Cigarette Smoke-induced Damage
Researchers investigated the potential benefit of mitochondrial transfer from human-induced pluripotent stem cell-derived mesenchymal stem cells (MSCs) to cigarette smoke-exposed airway epithelial cells in vitro and in vivo. [Am J Respir Cell Mol Biol] Abstract

Chondrogenic Phenotype of Articular Chondrocytes in Monoculture and Co-Culture with Mesenchymal Stem Cells in Flow Perfusion
Scientists investigated the effect of flow perfusion bioreactor culture with and without TGF-ß3 supplementation on the proliferation, extracellular matrix production, and chondrogenic gene expression of chondrocytes both in monoculture and in co-culture with bone marrow-derived mesenchymal stem cells. [Tissue Eng] Abstract

Effects of Enamel Matrix Derivative on the Proliferation and Osteogenic Differentiation of Human Gingival Mesenchymal Stem Cells
Recently, enamel matrix derivative (EMD) has been shown to enhance the proliferation and mineralization of human bone marrow mesenchymal stem cells. Because the gingival flap is the major component to cover the surgical wound, the effects of EMD on the proliferation and mineralization of gingiva-derived mesenchymal stem cells were evaluated. [Stem Cells Res Ther] Abstract | Full Article

Protein Synthesis and Secretion in Human Mesenchymal Cells Derived from Bone Marrow, Adipose Tissue and Wharton’s Jelly
Researchers isolated human mesenchymal stromal cells from bone marrow, adipose tissue and Wharton’s jelly and cultured them in fetal bovine serum supplemented media. They evaluated proliferation, in vitro differentiation, expression of cell surface markers and protein secretion using Luminex and ELISA assays. [Stem Cells Res Ther] Abstract | Full Article

Transforming Growth Factor-Beta Signaling-Dependent Alleviation of Dextran Sulfate Sodium-Induced Colitis by Mesenchymal Stem Cell Transplantation
Researchers transplanted primary mouse mesenchymal stem cells (MSC) into isogeneic mice with dextran sulfate sodium (DSS)-induced colitis. They found that MSC transplantation significantly alleviated the DSS-induced colitis. [Mol Biol Rep] Abstract

Human Umbilical Cord Blood Mesenchymal Stem Cell Transplantation Suppresses Inflammatory Responses and Neuronal Apoptosis during Early Stage of Focal Cerebral Ischemia in Rabbits
Researchers investigated the effects of human umbilical cord blood mesenchymal stem cells on inflammatory responses and neuronal apoptosis during the early stage of focal cerebral ischemia in rabbits. [Acta Pharmacol Sin] Abstract

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Mesenchymal Stromal Cells Used for Periodontal Regeneration: A Systematic Review
This systematic review has two goals: to objectively quantify key elements for efficacy and safety of mesenchymal stromal cells used for periodontal regeneration and to identify patterns in the existing literature to explain differences between studies and suggest recommendations for future research. [Stem Cells Transl Med] Abstract

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Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.
Osiris Announces Receipt of $15 Million Cash Payment for Prochymal
Osiris Therapeutics, Inc., a stem cell company focused on developing and marketing products to treat conditions in wound care, orthopedic and sports medicine markets, announced that it has received the next $15 million cash payment from Mesoblast in accordance with the Purchase Agreement relating to the Prochymal business. [Osiris Therapeutics, Inc.] Press Release

Aastrom Announces Definitive Agreement to Acquire Sanofi’s Cell Therapy and Regenerative Medicine Business
Aastrom Biosciences, Inc. announced that it has entered into a definitive agreement to acquire Sanofi’s Cell Therapy and Regenerative Medicine business for a purchase price of $6.5 million, with $4 million payable in cash at closing and $2.5 million payable in the form of a promissory note. [Aastrom Biosciences, Inc.] Press Release

inVentiv Health Clinical Engaged by IntelliCell Biosciences, a Regenerative Medicine Company, as Clinical Research Organization for Osteoarthritis IND
inVentiv Health Clinical announced that it has been selected for an osteoarthritis Investigational New Drug Application (IND) by IntelliCell BioSciences, Inc. IntelliCell will be studying the use of adult autologous vascular cells from blood vessels in adipose tissue to treat osteoarthritis of the knee. [inVentiv Health Clinical]
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NEW Tissue Engineering & Regenerative Medicine International Society (TERMIS) EU 2014 Congress
June 10-13, 2014
Genoa, Italy

Visit our events page to see a complete list of events in the mesenchymal cell community.
NEW Assistant Professor – Regenerative Medicine (University of Nebraska Medical Center)

Research Associate / Adjunct – Mesenchymal Stem Cells (Nicolaus Copernicus University)

Postdoctoral Fellowship – Hematology, Immunology, Cancer Therapeutics (Nationwide Children’s Hospital)

Postdoctoral Position – Intestinal Immunology (Biomedical Sciences Research Center “Alexander Fleming”)

Postdoctoral Fellow – Regenerative Medicine (University of California, San Francisco)

Postdoctoral Position – Cardiopulmonary Molecular Biology (Hannover Medical School)

Postdoctoral Associate – Cardiac Repair Mechanisms of Mesenchymal Stem Cells and Cardiac Stem Cells (University of Miami)

Director of GMP/GLP Quality Operations (University of Pennsylvania, Perelman School of Medicine)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

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