Volume 6.17 | May 6

Mesenchymal Cell News 6.17 May 6, 2014
Mesenchymal Cell News
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Engineers Grow Functional Human Cartilage in Lab
Researchers announced that they have successfully grown fully functional human cartilage in vitro from human stem cells derived from fat tissue. [Press release from Columbia University discussing online prepublication in the Proceedings of the National Academy of Sciences, USA] Press Release | Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Mesenchymal Stem Cells from Human Fat Engineered to Secrete BMP4 Are Nononcogenic, Suppress Brain Cancer, and Prolong Survival
The reciprocal effects of human adipose-derived mesenchymal stem cells on primary human brain tumor-initiating cells proliferation, differentiation, and migration were evaluated in vitro. [Clin Cancer Res]
Abstract | Press Release

Electro-Acupuncture Promotes the Survival and Differentiation of Transplanted Bone Marrow Mesenchymal Stem Cells Pre-Induced with Neurotrophin-3 and Retinoic Acid in Gelatin Sponge Scaffold after Rat Spinal Cord Transection
Mesenchymal stem cells were loaded into three-dimensional gelatin sponge scaffold. After seven days of induction with neurotrophin-3 and retinoic acid in vitro, scientists observed a significant increase in TrkC mRNA transcription by real-time PCR and this was confirmed by in situ hybridization. [Stem Cell Rev] Abstract

Repetitive Allogeneic Intraarticular Injections of Synovial Mesenchymal Stem Cells Promote Meniscus Regeneration in a Porcine Massive Meniscus Defect Model
Researchers examined the effect of repetitive intraarticular injections of synovial mesenchymal stem cells on meniscus regeneration in a massive meniscal defect of pigs. [Osteoarthritis Cartilage] Abstract

Ethyl-3,4-Dihydroxybenzoate with a Dual Function of Induction of Osteogenic Differentiation and Inhibition of Osteoclast Differentiation for Bone Tissue Engineering
The osteoinductive ability of ethyl-3,4-dihydroxybenzoate in pre-osteoblasts and human mesenchymal stem cells was examined. [Tissue Eng Part A] Abstract

Impact of Low Oxygen Tension on Stemness, Proliferation and Differentiation Potential of Human Adipose-Derived Stem Cells
Researchers found that hypoxia increased adipose-derived stem cells stemness marker expression and proliferation rate without altering their morphology and surface markers. Low oxygen tension further enhances the chondrogenic differentiation ability, but reduces both adipogenic and osteogenic differentiation potential. [Biochem Biophys Res Commun] Abstract

The Influence of Hypoxia on the Differentiation Capacities and Immunosuppressive Properties of Clonal Mouse Mesenchymal Stromal Cell Lines
Researchers showed that a panel of continuously growing mouse mesenchymal stromal cell lines, namely OP9, MS5, PA6, ST2 and B16-14, exhibit mesenchymal stromal cell characteristic phenotypes and respond physiologically to oxygen deprivation. [Immunol Cell Biol] Abstract

Conditioned Medium from Hypoxic Bone Marrow-Derived Mesenchymal Stem Cells Enhances Wound Healing in Mice
Scientists set out to elucidate and compare the impact of normoxic and hypoxic cell-culture conditions on the expression and secretion of bone marrow-derived mesenchymal stem cell-derived paracrine molecules that hypothetically contribute to cutaneous wound healing in vivo. [PLoS One] Full Article

Human Mesenchymal Stem Cell Spheroids in Fibrin Hydrogels Exhibit Improved Cell Survival and Potential for Bone Healing
Scientists hypothesized that forming mesenchymal stem cells into more physiologic three-dimensional spheroids, rather than employing dissociated cells from two-dimensional monolayer culture, will enhance their survival when exposed to a harsh microenvironment but maintain their osteogenic potential. [Cell Tissue Res] Abstract

Comparative Analysis of Multilineage Properties of Mesenchymal Stromal Cells Derived from Fetal Sources Shows an Advantage of Mesenchymal Stromal Cells Isolated from Cord Blood in Chondrogenic Differentiation Potential
Researchers showed that cord blood-mesenchymal stromal cell (MSCs) and amniotic fluid-MSCs collected at term differ from each other in their biological and differentiation properties. [Cytotherapy] Abstract

Functional Outcome after Anal Sphincter Injury and Treatment with Mesenchymal Stem Cells
Scientists demonstrated the regenerative effects of mesenchymal stem cells (MSCs) on the injured anal sphincter by comparing anal sphincter pressures following intramuscular and serial intravascular MSC infusion in a rat model of anal sphincter injury. [Stem Cells Transl Med] Abstract | Press Release

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Mesenchymal Stromal Cells in the Antimicrobial Host Response of Hematopoietic Stem Cell Recipients with Graft-versus-Host Disease – Friends or Foes?
The authors focus on the available data from in vitro studies and animal models regarding the interaction of mesenchymal stromal cells with bacterial, viral and fungal pathogens. [Leukemia] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

Stem Cells and Regenerative Medicine Asia Congress 2014
Americord Funds Clinical Trial Investigating Stem Cell Therapy for Alzheimer’s Disease
Americord announced that it has provided funding to MEDIPOST, a leading stem cell biotechnology company, to support their clinical trial investigating the use of NEUROSTEM-AD® in the treatment of patients with Alzheimer’s Disease. NEUROSTEM-AD® is a treatment agent for Alzheimer’s Disease that uses human umbilical cord blood-derived mesenchymal stem cells. [PR Newswire Association LLC] Press Release

C. Randal Mills Named as New President of California’s Stem Cell Agency
Describing him as a “visionary and highly regarded scientific and business leader” the California Institute for Regenerative Medicine, the state’s stem cell agency, today appointed C. Randal Mills, Ph.D., as its new President and Chief Executive Officer. [California Institute for Regenerative Medicine] Press Release

UGA to Use $5 Million Gift to Support Center for Molecular Medicine
A $5 million gift to support the Center for Molecular Medicine at the University of Georgia (UGA) will allow the institution to greatly advance its research into human disease. [University of Georgia] Press Release

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NEW European Society of Toxicology In Vitro 2014 International Conference
June 10-13, 2014
Egmond aan Zee, Netherlands

Visit our events page to see a complete list of events in the mesenchymal cell community.
NEW Postdoctoral Research Fellow – Adipose-Derived Stem Cells and Fat Metabolism (Agency for Science, Technology and Research – A*STAR)

NEW Postdoctoral Researcher – Mesenchymal Stem Cells and Regenerative Medicine (University of Crete)

NEW Postdoctoral Position – Transcriptional Networks of Mesenchymal Stem Cells (University of Southern Denmark)

NEW Research Technologist – hPSC (STEMCELL Technologies Inc.)

Developmental-Stem Cell Biologist (Mayo Clinic – Rochester)

Assistant Professor – Regenerative Medicine (University of Nebraska Medical Center)

Postdoctoral Fellowship – Hematology, Immunology, Cancer Therapeutics (Nationwide Children’s Hospital)

Postdoctoral Position – Intestinal Immunology (Biomedical Sciences Research Center “Alexander Fleming”)

Director of GMP/GLP Quality Operations (University of Pennsylvania, Perelman School of Medicine)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

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