Volume 6.18 | May 13

Mesenchymal Cell News 6.18 May 13, 2014
Mesenchymal Cell News
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Osterix Marks Distinct Waves of Primitive and Definitive Stromal Progenitors during Bone Marrow Development
Osterix-expressing cells perinatally contribute to osteolineages and long-lived bone marrow stroma, which have characteristics of Nestin-GFP+ mesenchymal stem and progenitor cells. [Dev Cell]
Abstract | Graphical Abstract
Achieve Superior Differentiation of Mouse MSC & MEF into Osteoblasts with the New MesenCult™ Osteogenic Stimulatory Kit (Mouse)
PUBLICATIONS (Ranked by impact factor of the journal)
Dopamine Mobilizes Mesenchymal Progenitor Cells through D2-Class Receptors and Their PI3K/AKT Pathway
Researchers showed that dopamine induced in vitro, mesenchymal progenitor cells migration through D2-class receptors, and their alternative PI3K/Akt pathways. [Stem Cells] Abstract

Uremic Toxin p-Cresol Induces Akt-Pathway-Selective Insulin Resistance in Bone Marrow-Derived Mesenchymal Stem Cells
Scientists characterized insulin signaling in mesenchymal stem cells (MSCs) and investigated the effect of uremic toxin, p-cresol, on the proangiogenic actions of insulin. In MSCs, insulin induced hypoxia-inducible factor-1α vascular endothelial growth factor, and stromal cell-derived factor-1α expressions via PI3K/Akt-dependent pathway. [Stem Cells] Abstract

Loss of Gsα Early in the Osteoblast Lineage Favors Adipogenic Differentiation of Mesenchymal Progenitors and Committed Osteoblast Precursors
Researchers showed that targeted ablation of Gsα in early osteoblast precursors, but not in differentiated osteocytes, results in a dramatic increase in bone marrow adipocytes. [J Bone Miner Res] Abstract

Direct T Cell-Tumor Interaction Triggers TH1 Phenotype Activation through the Modification of the Mesenchymal Stromal Cells Transcriptional Program
Researchers co-cultured human mesenchymal stromal cells (MSCs), tumor infiltrating lymphocytes, and melanoma cells to investigate the role of MSCs in the tumor environment. [Br J Cancer] Full Article

Periostin Secreted by Mesenchymal Stem Cells Supports Tendon Formation in an Ectopic Mouse Model
Overexpression of periostin alone or in combination with constitutively active BMP receptor type in human mesenchymal stem cells and subsequent implantation into ectopic sites in mice demonstrated a reproducible moderate tenogenic capacity that has not been described before. [Stem Cells Dev] Abstract

Characteristics and Properties of Mesenchymal Stem Cells Derived from Micro-Fragmented Adipose Tissue
Human adipose derived stem cells derived from microfragmented lipoaspirate tissue have been systematically characterized for growth features, phenotype and multi-potent differentiation potential. They fulfill the definition of mesenchymal stem cells although with a higher neural phenotype profile. [Cell Transplant] Abstract

Bone Marrow Stromal Cell Paracrine Factors Direct Osteo/Odontogenic Differentiation of Dental Pulp Cells
Scientists compared the biological effects of recombinant human growth differentiation factor five alone and a cocktail of soluble growth factors release from human bone marrow mesenchymal stem cells on the morphology, proliferation and osteo/odontogenic differentiation potential of human dental pulp cells. [Tissue Eng Part A] Abstract

Proteomic Analysis of Mesenchymal Stem Cells from Normal and Deep Carious Dental Pulp
Researchers defined the molecular features of dental pulp stem cells and carious dental pulp stem cells by comparing the proteomic profiles using two-dimensional fluorescence difference gel electrophoresis in combination with matrix-assisted laser desorption ionization time-of-flight mass spectrometry. [PLoS One]
Full Article

Changes in PTTG1 by Human TERT Gene Expression Modulate the Self-Renewal of Placenta-Derived Mesenchymal Stem Cells
Scientists generated immortalized mesenchymal stem cells (MSCs) derived from MSCs isolated from placenta by human TERT gene transfection with the AMAXA gene delivery system, to compare their characteristics, and to investigate whether increased TERT expression affected the pituitary tumor transforming gene (PTTG1), which is involved in chromosome segregation during mitosis. [Cell Tissue Res] Abstract

Bone Marrow-Derived Mesenchymal Stem Cells Migrate to Healthy and Damaged Salivary Glands following Stem Cell Infusion
Researchers evaluated stem cell distribution following intravenous and intraglandular injections using a surgical model of salivary gland damage and to analyze the effects of mesenchymal stem cell injections on the recruitment of immune cells. [Int J Oral Sci] Full Article

mTeSR™1: Most Published Feeder-Free hPSC Maintenance Medium. Click to View Top Applications
Adipose-Derived Stromal Cells for Osteoarticular Repair: Trophic Function versus Stem Cell Activity
Focusing on bone and cartilage repair, this review summarizes recent in vitro and in vivo studies aiming towards tissue regeneration with adipose-derived stromal cells. [Expert Rev Mol Med] Full Article

The Current Landscape of Adipose-Derived Stem Cells in Clinical Applications
The authors highlight the clinical applicability of adipose-derived stem cells as well as their progress in clinical trials across various medical disciplines. [Expert Rev Mol Med] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

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Taxus Cardium’s Excellagen® Selected for Use with Stem Cells in EU-Funded Human Clinical Study
Taxus Cardium Pharmaceuticals Group Inc. announced that the company’s Excellagen® flowable dermal matrix in combination with Orbsen Therapeutics’ mesenchymal stromal stem cell therapy Cyndacel-M™ has been selected for clinical evaluation in a Phase Ib safety study for the potential treatment of chronic diabetic wounds to be funded by the European Union under EU Framework 7. [Taxus Cardium Pharmaceuticals Group Inc.]
Press Release

STEMCELL Technologies Inc. Has Just Released NEW MesenCult™ Proliferation Kit with MesenPure™ (Mouse), a Novel Cell Culture Medium to Advance Research on Mouse Mesenchymal Stem and Progenitor Cells (MSCs)
MesenCult™ Proliferation Kit with MesenPure™ (Mouse) is a novel cell culture medium to advance research on mouse mesenchymal stem and progenitor cells (MSCs). [STEMCELL Technologies Inc.] Press Release

From our sponsor: Pluripotent cell isolation for regenerative medicine. Request a free wallchart from Nature.
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NEW The Federation of European Biochemical Societies (FEBS)–European Molecular Biology Organization (EMBO) 2014 Conference
August 30 – September 4, 2014
Paris, France

Visit our events page to see a complete list of events in the mesenchymal cell community.
NEW PhD Position – Epigenomic Profiling of Adipocyte Differentiation (German Cancer Research Center [DKFZ])

Postdoctoral Research Fellow – Adipose-Derived Stem Cells and Fat Metabolism (Agency for Science, Technology and Research – A*STAR)

Postdoctoral Position – Transcriptional Networks of Mesenchymal Stem Cells (University of Southern Denmark)

Developmental-Stem Cell Biologist (Mayo Clinic – Rochester)

Assistant Professor – Regenerative Medicine (University of Nebraska Medical Center)

Postdoctoral Fellowship – Hematology, Immunology, Cancer Therapeutics (Nationwide Children’s Hospital)

Postdoctoral Position – Intestinal Immunology (Biomedical Sciences Research Center “Alexander Fleming”)

Director of GMP/GLP Quality Operations (University of Pennsylvania, Perelman School of Medicine)

Research Technologist – hPSC (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

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