Volume 6.19 | May 20

Mesenchymal Cell News 6.19 May 20, 2014
Mesenchymal Cell News
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Stimulation of Mesenchymal Stromal Cells (MSCs) via TLR3 Reveals a Novel Mechanism of Autocrine Priming
Researchers investigated the inflammatory responses of MSCs isolated from human nasal mucosa upon challenge with different Toll-like receptor (TLR) ligands. [FASEB J] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Allogeneic Bone Marrow Mesenchymal Stem Cell Transplantation in Patients with UDCA-Resistant Primary Biliary Cirrhosis
Researchers evaluated the safety and efficacy of allogeneic bone marrow mesenchymal stromal/stem cell transplantation for patients with ursodeoxycholic acid (UDCA)-resistant primary biliary cirrhosis. [Stem Cells Dev] Abstract

Intermittent PTHrP(1-34) Exposure Augments Chondrogenesis and Reduces Hypertrophy of Mesenchymal Stromal Cells
Scientists investigated whether intermittent supplementation of parathyroid hormone-related protein (PTHrP), as opposed to constant treatment, can beneficially influence mesenchymal stromal cell chondrogenesis and to explore molecular mechanisms below catabolic and anabolic responses. [Stem Cells Dev] Abstract

Different Forms of Tenascin-C with Tenascin-R Regulate Neural Differentiation in Bone Marrow-Derived Human Mesenchymal Stem Cells
A combination of tenascinC and tenascinR significantly promoted human bone marrow-derived mesenchymal stem cells differentiation in neurons or oligodendrocytes, induced neurite formation, and inhibited differentiation into astrocytes. [Tissue Eng Part A] Abstract

SOCS1 Regulates the Immune Modulatory Properties of Mesenchymal Stem Cells by Inhibiting Nitric Oxide Production
Scientists found the suppressor of cytokine signaling 1 (SOCS1) was induced in mesenchymal stem cells (MSCs) treated with inflammatory cytokines. Knockdown of SOCS1 did not bring much difference on the proliferation and differentiation properties of MSCs. [PLoS One] Full Article

Human Mesenchymal Cells from Adipose Tissue Deposit Laminin and Promote Regeneration of Injured Spinal Cord in Rats
Researchers investigated the regenerative properties of human adipose tissue derived stromal cells (hADSCs) in a rat model of spinal cord compression. Cells were delivered directly into the spinal parenchyma immediately after injury. Human ADSCs promoted functional recovery, tissue preservation, and axonal regeneration. [PLoS One] Full Article

Substrate Stiffness and Oxygen Availability as Regulators of Mesenchymal Stem Cell Differentiation within a Mechanically Loaded Bone Chamber
Researchers employed a previously developed computational framework to test the hypothesis that substrate stiffness and oxygen availability regulate stem cell differentiation during tissue regeneration within an implanted bone chamber. [Biomech Model Mechanobiol] Abstract

Tolerogenic Effect of Mesenchymal Stromal Cells on Gliadin-Specific T Lymphocytes in Celiac Disease
Scientists investigated the effects of mesenchymal stromal cells on gliadin-specific T cells, which are known to induce intestinal lesions, in view of a possible use as new therapy. [Cytotherapy] Abstract

Enhancement of Adhesion and Promotion of Osteogenic Differentiation of Human Adipose Stem Cells by Poled Electroactive Poly(Vinylidene Fluoride)
Non-electroactive α-poly(vinylidene fluoride) (PVDF) and electroactive β-PVDF were used to investigate the substrate polarization and polarity influence on the focal adhesion size and number as well as on human adipose stem cells differentiation. [J Biomed Mater Res A] Abstract

Enhancement of Mouse Germ Cell-Associated Genes Expression by Injection of Human Umbilical Cord Mesenchymal Stem Cells into the Testis of Chemical-Induced Azoospermic Mice
Researchers investigated whether injection of human umbilical cord mesenchymal stem cells into the interstitial compartment of the testes to promote spermatogenic regeneration efficiently. [Asian J Androl] Full Article

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Enhancing Chondrogenic Phenotype for Cartilage Tissue Engineering: Monoculture and Co-Culture of Articular Chondrocytes and Mesenchymal Stem Cells
The authors focus on the use of articular chondrocytes and mesenchymal stem cells in either monoculture or co-culture for the enhancement of chondrogenesis. [Tissue Eng Part B Rev] Abstract

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Orbsen Therapeutics Cell Therapy Selected for Diabetic Wound Clinical Trial Led by NUI Galway and Steno Diabetes Centre
Orbsen Therapeutics proprietary stromal cell therapy has been selected to be tested in a EU Framework 7 funded safety trial for the treatment of non-healing, ulcerating wounds in patients with diabetes. [Orbsen Therapeutics] Press Release

NeoStem’s Subsidiary, Progenitor Cell Therapy (PCT), Awarded FACT Re-Accreditation for New Jersey and California Facilities
NeoStem, Inc. and its subsidiary, Progenitor Cell Therapy, LLC announced that PCT has been awarded re-accreditation by the Foundation for the Accreditation of Cellular Therapy (FACT). [NeoStem, Inc.] Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW BIO Latin America
August 9-11, 2014
Rio de Janeiro, Brazil

Visit our events page to see a complete list of events in the mesenchymal cell community.
NEW Postdoctoral Fellow – Cell Therapy with Umbilical Mesenchymal Stem Cells (University of Cincinnati)

PhD Position – Epigenomic Profiling of Adipocyte Differentiation (German Cancer Research Center [DKFZ])

Postdoctoral Research Fellow – Adipose-Derived Stem Cells and Fat Metabolism (Agency for Science, Technology and Research – A*STAR)

Postdoctoral Position – Transcriptional Networks of Mesenchymal Stem Cells (University of Southern Denmark)

Developmental-Stem Cell Biologist (Mayo Clinic – Rochester)

Assistant Professor – Regenerative Medicine (University of Nebraska Medical Center)

Postdoctoral Fellowship – Hematology, Immunology, Cancer Therapeutics (Nationwide Children’s Hospital)

Director of GMP/GLP Quality Operations (University of Pennsylvania, Perelman School of Medicine)

Research Technologist – hPSC (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

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