Volume 6.20 | May 27

Mesenchymal Cell News 6.20 May 27, 2014
Mesenchymal Cell News
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A Comparison of Bone Regeneration with Human Mesenchymal Stem Cells and Muscle-Derived Stem Cells and the Critical Role of BMP
Although human skeletal muscle-derived stem cells (hMDSCs) can undergo osteogenic differentiation and form bone when genetically modified to express BMP2; it is still unclear whether hMDSCs are as efficient as human bone marrow mesenchymal stem cells (hBMMSCs) for bone regeneration. Scientists aimed to address this question by performing a parallel comparison between hMDSCs and hBMMSCs to evaluate their osteogenic and bone regeneration capacities. [Biomaterials] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Selective Inhibition of Inositol Hexakisphosphate Kinases (IP6Ks) Enhances Mesenchymal Stem Cell Engraftment and Improves Therapeutic Efficacy for Myocardial Infarction
Researchers investigated the role of IP6Ks for improving mesenchymal stem cells’ functional survival and cardiac protective effect after transplantation into infarcted mice hearts. [Basic Res Cardiol] Abstract

Modulation of the Early Inflammatory Microenvironment in the Alkali-Burned Eye by Systemically Administered Interferon-γ-Treated Mesenchymal Stromal Cells
Scientists investigated the effects of systemically administered bone marrow-derived mesenchymal stromal cells on the early acute phase of inflammation in the alkali-burned eye. [Stem Cells Dev] Abstract

Generation and Characterization of an Immortalized Human Mesenchymal Stromal Cell Line
Researchers describe the generation of a telomerase-immortalized non-tumorigenic human bone marrow-derived stromal mesenchymal cell line, and its detailed characterization after long term culturing. [Stem Cells Dev] Abstract

Electroacupuncture Promotes the Differentiation of Transplanted Bone Marrow Mesenchymal Stem Cells Pre-Induced with Neurotrophin-3 and Retinoic Acid into Oligodendrocyte-Like Cells in Demyelinated Spinal Cord of Rats
Researchers transplanted neurotrophin-3 (NT-3) and retinoic acid pre-induced mesenchymal stem cells into a demyelinated spinal cord induced by ethidium bromide, and investigated whether EA treatment could promote NT-3 secretion in the demyelinated spinal cord. [Cell Transplant] Full Article

Positive Selection for Bone Morphogenetic Protein Receptor Type-IB (BMPR-IB) promotes Differentiation and Specification of Human Adipose-Derived Stromal Cells towards an Osteogenic Lineage
Human adipose-derived stromal cell subpopulations were prospectively isolated based on expression of BMPR-IB. Unsorted BMPR-IB(+) and BMPR-IB(-) cells were analyzed for their osteogenic capacity through histological staining and gene expression. [Tissue Eng Part A] Abstract

Correlating the Effects of BMP to Secreted Soluble Factors from Fibroblasts and Mesenchymal Stem Cells in Regulating Regenerative Processes In Vitro
Scientists investigated the effect of soluble factors secreted by fibroblasts and mesenchymal stem cells on the proliferation and migration of cells from the regeneration-competent and -incompetent regions of the mouse digit tip. [Tissue Eng Part A] Abstract

Mesenchymal Stem Cells Derived from Human Exfoliated Deciduous Teeth (SHEDs) Induce Immune Modulatory Profile in Monocyte-Derived Dendritic Cells
SHEDs are readily accessible, but their immune regulatory properties have not been completely investigated. Researchers evaluated the SHEDs influence on dendritic cells differentiation, maturation, ability to activate T cells and to expand CD4+Foxp3+ T cells. [PLoS One] Full Article

Regulating Chondrogenesis of Human Mesenchymal Stromal Cells with a Retinoic Acid Receptor-Beta Inhibitor: Differential Sensitivity of Chondral Versus Osteochondral Development
Researchers investigated whether the synthetic retinoic acid receptor-β antagonist LE135 is able to drive in vitro chondrogenesis of human mesenchymal stromal cells or improve differentiation by suppressing hypertrophic chondrocyte development. [Cell Physiol Biochem] Full Article

Multi-Lineage Differentiation of Human Mesenchymal Stromal Cells on the Biophysical Microenvironment of Cell-Derived Matrix
Under osteogenic conditions, human bone-marrow-derived stromal cells exhibited higher amounts of both mineralized nodule formation and alkaline phosphatase expression than those cultured on plastic or gelatin. [Cell Tissue Res] Abstract

Human Placenta Mesenchymal Stem Cells Expressing Exogenous Kringle1-5 Protein by Fiber-Modified Adenovirus Suppress Angiogenesis
Scientists report human placenta-derived mesenchymal stem cell-based gene therapy using a fiber-modified adenoviral vector carrying the kringle1-5 gene to maintain long-term survival and effectively suppress angiogenesis both in vitro and in vivo. [Cancer Gene Ther] Abstract

Osteogenic Differentiation of Umbilical Cord and Adipose Derived Stem Cells onto Highly Porous 45S5 Bioglass®-Based Scaffolds
Researchers evaluated bioactive glass (45S5 Bioglass®) samples as scaffold materials for mesenchymal stem cells. Pore architecture of the scaffolds as well as cell behavior in the 3D environment was evaluated by several methods. [J Biomed Mater Res A] Abstract

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Mesenchymal Stem Cells as Cellular Vectors for Pediatric Neurological Disorders
Recently, direct intracranial transplantation of tissue-specific stem and progenitor cells has been explored as a means to reconstitute metabolic deficiencies in the central nervous system. The authors discuss the merits of bone marrow-derived mesenchymal stem cells for this purpose. [Brain Res] Abstract

The Potential of Mesenchymal Stem Cell in Prion Research
The authors review the use of cell models in prion research with a special interest in the potential use of mesenchymal stem cells. [Zoonoses Public Health] Abstract

TGF-β Signaling and the Development of Osteoarthritis
This review focuses on the function and signaling mechanisms of TGF-β/SMAD pathway in articular chondrocytes, mesenchymal progenitor cells of subchondral bone and synovial lining cells during osteoarthritis development. [Bone Res] Full Article

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.
Gene Therapy Section Formed within the Alliance for Regenerative Medicine
The Alliance for Regenerative Medicine (ARM) and the American Society of Gene & Cell Therapy announced their partnership. ARM’s new Gene and Gene-Modified Cell Therapy Section brings together the leading gene therapy companies and organizations in the U.S. and Europe to advocate for policies and programs to accelerate the development of new therapeutics to treat and cure a range of diseases for which no effective treatment options are available. [The Alliance for Regenerative Medicine] Press Release

Stem Cell Research on Campus Grows after $3 Million Boost
Recently Cornell Stem Cell Program researchers Professor John Schimenti and Nikitin received $3 million from the New York State Stem Cell Science program of the New York State Department of Health to support the Stem Cell Modeling and Phenotyping Core. [Cornell University] Press Release

Maryland Stem Cell Research Commission Funds 31 New Research Proposals in FY 2014 with Continued Focus on Contributing to Cures for Debilitating Diseases and Conditions
The board of directors of the Maryland Technology Development Corporation approved the Maryland Stem Cell Research Commission’s recommendation to fund 31 new proposals with the Maryland Stem Cell Research Fund’s $10.4 million FY2014 budget. [Maryland Stem Cell Research Fund] Press Release

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September 15-16, 2014
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October 20-23, 2014
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Visit our events page to see a complete list of events in the mesenchymal cell community.
NEW PhD Position – The Role of Chromatin in Alternative Splicing Regulation during Cell Fate Decision (Institute of Molecular Biology)

NEW PhD Studentships – Musculoskeletal Tissue Engineering and Regenerative Medicine (University of Cambridge)

NEW Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Postdoctoral Fellow – Cell Therapy with Umbilical Mesenchymal Stem Cells (University of Cincinnati)

PhD Position – Epigenomic Profiling of Adipocyte Differentiation (German Cancer Research Center [DKFZ])

Developmental-Stem Cell Biologist (Mayo Clinic – Rochester)

Assistant Professor – Regenerative Medicine (University of Nebraska Medical Center)

Postdoctoral Fellowship – Hematology, Immunology, Cancer Therapeutics (Nationwide Children’s Hospital)

Director of GMP/GLP Quality Operations (University of Pennsylvania, Perelman School of Medicine)

Research Technologist – hPSC (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

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