Volume 6.24 | Jun 24

Mesenchymal Cell News 6.24 June 24, 2014
Mesenchymal Cell News
     In this issue: Publications | Reviews | Science News | Industry News | Policy News | Events | Jobs
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TOP STORY
Children’s Research Institute Finds Key to Identifying, Enriching Mesenchymal Stem Cells
Researchers have identified a biomarker that enables researchers to accurately characterize the properties and function of mesenchymal stem cells in the body. [Press release from The University of Texas Southwestern Medical Center discussing online prepublication in Cell Stem Cell]
Press Release | Abstract | Graphical Abstract
Free Cell Stem Cell Poster: Directed Differentiation of ESCs/iPSCs
 
PUBLICATIONS (Ranked by impact factor of the journal)
A Novel PPARγ2 Modulator sLZIP Controls the Balance between Adipogenesis and Osteogenesis during Mesenchymal Stem Cell Differentiation
The role of sLZIP in regulation of PPARγ2 transcriptional activation was investigated along with sLZIP’s involvement in differentiation of mesenchymal stem cells into adipocytes and osteoblasts. [Cell Death Differ] Abstract

Non-Viral Oligonucleotide AntimiR-138 Delivery to Mesenchymal Stem Cell Sheets and the Effect on Osteogenesis
Investigators aimed to verify the feasibility of non-viral oligonucleotide delivery for the cell sheets and to confirm the osteogenesis enhancing effect of antimiR-138 on the cell sheets composed of bone marrow mesenchymal stem cells. [Biomaterials] Abstract

The IL-6-STAT3 Axis Mediates a Reciprocal Crosstalk between Cancer-Derived Mesenchymal Stem Cells and Neutrophils to Synergistically Prompt Gastric Cancer Progression
Researchers investigated the interaction between neutrophils and gastric cancer-derived mesenchymal stem cells (GC-MSCs) and explored the biological role of this interaction. They found that GC-MSCs induced the chemotaxis of neutrophils and protected them from spontaneous apoptosis. [Cell Death Dis] Full Article

Carbon Nanotube – Collagen Three-Dimensional Culture of Mesenchymal Stem Cells Promotes Expression of Neural Phenotypes and Secretion of Neurotrophic Factors
Scientists focused on carbon nanotubes dispersed within collagen hydrogels to provide three dimensional microenvironmental conditions for mesenchymal stem cells in stimulating biological functions for neural regeneration. [Acta Biomater] Abstract

Sequential Third-Party MSC Therapy for Refractory Acute Graft-versus-Host Disease
Researchers evaluated the feasibility, safety and efficacy of the administration of four sequential doses of cryopreserved bone marrow-derived mesenchymal stromal cells (MSC) expanded with platelet lysate and obtained from third-party donors as second line treatment for steroid refractory acute graft-versus-host disease in a series of 25 patients. [Biol Blood Marrow Transplant] Abstract

Tonsil-Derived Mesenchymal Stem Cells Alleviate Concanavalin A-Induced Acute Liver Injury
Intravenous administration of tonsil-derived mesenchymal stem cells (T-MSCs) significantly reduced concanavalin A-induced hepatic toxicity, but not acetaminophen-induced liver injury, affirming the immunoregulatory capacity of T-MSCs. [Exp Cell Res] Abstract

Secreted Adiponectin as a Marker to Evaluate In Vitro the Adipogenic Differentiation of Human Mesenchymal Stromal Cells
Scientists investigated whether it is possible to assess mesenchymal stromal cell adipogenic differentiation in a more efficient, timely and non-destructive manner, while monitoring in vitro secretion of adiponectin, a hormone specifically secreted by adipose tissue. [Cytotherapy] Abstract

Enhanced Proliferation and Differentiation of Oct4- and Sox2-Overexpressing Human Adipose Tissue Mesenchymal Stem Cells
Oct4/Sox2-overexpressing adipose tissue mesenchymal stem cells showed higher differentiation abilities for adipocytes or osteoblasts than controls. The markers of adipogenic or osteogenic differentiation were also upregulated by Oct4/Sox2 overexpression. [Exp Mol Med] Full Article

An Integrated Study of Natural Hydroxyapatite-Induced Osteogenic Differentiation of Mesenchymal Stem Cells Using Transcriptomics, Proteomics and MicroRNA Analyses
Researchers combined transcriptomics, proteomics, and microRNA analyses to elucidate the mechanism of natural hydroxyapatite-induced osteogenic differentiation of mesenchymal stem cells. [Biomed Mater] Abstract

Sustained Expression of Coagulation Factor IX by Modified Cord Blood-Derived Mesenchymal Stromal Cells
Modification of human CB mesenchymal stromal cells with a lentiviral vector resulted in sustained high Factor IX expression in vitro following differentiation to adipogenic, chondrogenic and osteoblastic cells. [J Gene Med] Abstract

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REVIEWS
Immune Modulation to Improve Tissue Engineering Outcomes for Cartilage Repair in the Osteoarthritic Joint
The authors discuss the role of inflammation in osteoarthritis (OA), and investigate novel immune modulation strategies which may prevent disease progression and facilitate successful cartilage regeneration for the treatment of OA. [Tissue Eng Part B Rev] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

BioProcess International Conference & Exhibition - Boston MA
 
SCIENCE NEWS
MAX BioPharma Produces New Potent Bone-Targeted Osteogenic Small Molecule Oxysterols; Receives Second NIH Funded SBIR Grant
MAX BioPharma announced that it has successfully designed and synthesized proprietary small molecule oxysterols that are bone-targeted and possess potent osteogenic activity. The research was conducted as part of MAX BioPharma’s first SBIR grant-supported activities in the area of osteoporosis. [Press release from PR Newswire Association LLC discussing research to be presented at the BIO International Convention, San Diego] Press Release

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INDUSTRY NEWS
Pluristem Receives Patent in India for Cell Therapy Production Methods and Compositions
Pluristem Therapeutics Inc. announced it has been granted Patent No. 261087 from India’s Office of the Controller General of Patents, Designs & Trade Marks for a patent titled, “Methods for Cell Expansion and Conditioned Media Produced Thereby for Therapy.” [Pluristem Therapeutics Inc.] Press Release

Three Groundbreaking Biotech Startups Receive Funding from Peter Thiel’s Breakout Labs
EpiBone, based in the newly opened Harlem Biospace, uses computed tomography scans and fat-derived stem cells to engineer the patient’s own living bone with the precise anatomical fit to the defect being treated. [Business Wire] Press Release
 
POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Advances in Stem Cell Research 2014
September 16-17, 2014
Online

Visit our events page to see a complete list of events in the mesenchymal cell community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Fellow – Molecular and Cellular Biology of Bone (University of Connecticut Health Center)

NEW Scientist – Mesenchymal Stem and Progenitor Cell Biology (STEMCELL Technologies Inc.)

NEW Scientist – Myogenic Progenitor Cell Biology (STEMCELL Technologies Inc.)

NEW Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

NEW Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Postdoctoral Position – Bioengineering (The Andalusian Centre for Nanomedicine and Biotechnology)

Postdoctoral Position – Mesenchymal Stem Cells (University of Southern California)

Postdoctoral Position – Cellular Therapy and Regenerative Medicine of Ocular Pathology (IDIBAPS – August Pi i Sunyer Biomedical Research Institute)

Instructor – Regulation of Stem Cell Differentiation in Vascular Disease (University of Alabama at Birmingham)

Postdoctoral Research Scholar – The Role of Mesenchymal Factors in Cancer Progression (Washington University School of Medicine)

Postdoctoral Position – Epigenetics and Stem Cell Biology (Max Planck Institute for Heart and Lung Research)

PhD Position – The Role of Chromatin in Alternative Splicing Regulation during Cell Fate Decision (Institute of Molecular Biology)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)


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