Volume 6.26 | Jul 15

Mesenchymal Cell News 6.26 July 15, 2014
Mesenchymal Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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Effects of the Endocrine-Disrupting Chemical DDT on Self-Renewal and Differentiation of Human Mesenchymal Stem Cells
Human mesenchymal stem cells (MSCs) exposed to DDT were used to evaluate the impact on stem cell biology. DDT-treated MSCs were assessed for self-renewal, proliferation, and differentiation potential. [Environ Health Perspect] Abstract | Full Article
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PUBLICATIONS (Ranked by impact factor of the journal)
Adipose Tissue-Derived Mesenchymal Stem Cells Cultured at High Density Express IFN-β and Suppress the Growth of MCF-7 Human Breast Cancer Cells
Scientists found that type I interferon is expressed in adipose tissue-derived stem cells (ASCs) cultured at high density, and ASCs and their conditioned medium suppress the growth of MCF-7 cells in vitro. [Cancer Lett] Abstract

Identification of Stable Reference Genes for Gene Expression Analysis of Three-Dimensionally Cultivated Human Bone Marrow-Derived Mesenchymal Stromal Cells for Bone Tissue Engineering
Mesenchymal stromal cells isolated from bone marrow aspirates were cultivated on human cancellous bone cube scaffolds for 14 days. Osteogenic differentiation was assessed by cell-specific alkaline phosphatase activity and expression of osteogenic marker genes. [Tissue Eng Part C Methods] Abstract

The Use of Adipose Mesenchymal Stem Cells and Human Umbilical Vascular Endothelial Cells on a Fibrin Matrix for Endothelialized Skin Substitute
Scientists produced a new model of endothelialized skin substitute that promotes the formation of capillary-like structures by seeding human umbilical vein endothelial cells with dermal fibroblasts and adipose derived mesenchymal stem cells in a fibrin matrix. [Tissue Eng Part A] Abstract

Immunomodulatory Effects of Bone Marrow-Derived Mesenchymal Stem Cells on Pro-Inflammatory Cytokine-Stimulated Human Corneal Epithelial Cells
Scientists investigated the modulatory effect of rat bone marrow mesenchymal stem cells on human corneal epithelial cells stimulated with pro-inflammatory cytokines interferon gamma and tumor necrosis factor alpha in an in vitro co-cultured model. [PLoS One] Full Article

Toll Like Receptor 3 & 4 Responses of Human Turbinate Derived Mesenchymal Stem Cells: Stimulation by Double Stranded RNA and Lipopolysaccharide
Researchers investigated the influence of Toll like receptor on the immune response, proliferation, and differentiation potential of human turbinated mesenchymal stromal cell cultures in vitro. [PLoS One] Full Article

In Vitro Characterization of Scaffold-Free Three-Dimensional Mesenchymal Stem Cell Aggregates
Scientists describe a novel method for generating and culturing rabbit mesenchymal stem cells (MSCs) as scaffold-free three dimensional cell aggregates by using micropatterned wells via a forced aggregation technique. The viability and proliferative capability of MSC aggregates were assessed via Live/Dead staining and 5-ethynyl-2’-deoxyuridine incorporation. [Cell Tissue Res] Abstract

High Extracellular Magnesium Inhibits Mineralized Matrix Deposition and Modulates Intracellular Calcium Signaling in Human Bone Marrow-Derived Mesenchymal Stem Cells
Researchers examined the effects of extracellular Mg2+ on the deposition of calcium phosphate matrix and Ca2+ signaling with or without ATP stimulation in human bone marrow-derived mesenchymal stem cells. [Biochem Biophys Res Commun] Abstract

Bone Marrow Mesenchymal Stem Cells Ameliorate Colitis-Associated Tumorigenesis in Mice
Mesenchymal stem cells (MSCs) were isolated from the bone marrow of allogenic mice and identified by flow cytometry. Mice in the model of colitis-associated tumorigenesis induced by azoxymethane and dextran sulfate sodium were injected with MSCs. [Biochem Biophys Res Commun] Abstract

Low Frequency Magnetic Force Augments Hepatic Differentiation of Mesenchymal Stem Cells on a Biomagnetic Nanofibrous Scaffold
Researchers evaluated hepatic trans-differentiation potential of human mesenchymal stem cells on a biomagnetic electrospun nanofibrous scaffold fabricated from a blend of poly-l-lactide, collagen and fibrin-rich blood clot, under the influence of a low frequency magnetic field. [J Mater Sci Mater Med] Abstract

Safety of Repeated Transplantations of Neurotrophic Factors-Secreting Human Mesenchymal Stromal Stem Cells
Scientists studied the toxicity and tolerability of three consecutive intramuscular injections of cryopreserved human mesenchymal stem cell-neurotrophic factor-secreting cells in C57BL/B6 mice to investigate the effect of repeated administration of these cells. [Clin Transl Med] Abstract | Full Article

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Signaling Pathways Involved in Osteogenesis and Their Application for Bone Regenerative Medicine
The authors provide an overview of the signaling mechanisms involved in bone regeneration and remodeling and the osteogenic potential of mesenchymal stromal cells to become a key cellular resource for such regeneration and remodeling processes. [Tissue Eng Part B Rev] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

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Biotech Company Receives Application Approval from Chinese Food and Drug Administration
Beike Biotechnology Co., Ltd. has officially been accepted into the approval process for the Chinese Food and Drug Administration for the use of human umbilical cord derived mesenchymal stem cells for clinical translation and treatment of systemic lupus erythematosus. [Beike Biotechnology Co., Ltd. (PR Newswire Association LLC)] Press Release

BioTime Announces Issuance of 14 Patents in the Fields of Regenerative Medicine, and Cancer Diagnosis and Therapy
BioTime, Inc. announced the issuance of 14 new patents to BioTime and its subsidiary companies. The patents issued in Australia, Canada, China, Japan, and the United States, cover a wide range of core technologies foundational to BioTime’s businesses. [BioTime, Inc.] Press Release

NIH Awards Scripps Researchers $2.6 Million to Develop Stem Cell Lines
Scientists from the Florida campus of The Scripps Research Institute have been awarded a $2.6 million grant from the office of the director of the National Institutes of Health (NIH) to produce specialized stems cells. [Genetic Engineering & Biotechnology News] Article

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW EMBO Conference: Stem Cells in Cancer and Regenerative Medicine
October 9-12, 2014
Heidelberg, Germany

Visit our events page to see a complete list of events in the mesenchymal cell community.
NEW Postdoctoral Fellow – Crosstalk and Interactions between Skeletal Cells and the Blood Vessels of Bone (KU Leuven)

PhD Studentship – Effects of Aging on MSC Therapy Activity (Loughborough University)

PhD Position – Pericyte Function and Dysfunction in CNS Disease (Lund University)

Research Assistant / Associate Positions – Regenerative Medicine (University of Glasgow)

Postdoctoral Fellow – Molecular and Cellular Biology of Bone (University of Connecticut Health Center)

Postdoctoral Position – Mesenchymal Stem Cells (University of Southern California)

Instructor – Regulation of Stem Cell Differentiation in Vascular Disease (University of Alabama at Birmingham)

Postdoctoral Research Scholar – The Role of Mesenchymal Factors in Cancer Progression (Washington University School of Medicine)

Postdoctoral Position – Epigenetics and Stem Cell Biology (Max Planck Institute for Heart and Lung Research)

Scientist – Mesenchymal Stem and Progenitor Cell Biology (STEMCELL Technologies Inc.)

Scientist – Myogenic Progenitor Cell Biology (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

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