Volume 6.27 | Jul 22

Mesenchymal Cell News 6.27 July 22, 2014
Mesenchymal Cell News
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Tenogenic Induction of Human MSCs by Anisotropically Aligned Collagen Biotextiles
A 3D-biotextile was woven purely from collagen. Mesenchymal stem cells (MSCs) seeded in the woven scaffold underwent tenogenic differentiation in the absence of growth factors and synthesized a matrix that is positive for tenomodulin, COMP and type I collagen. [Adv Funct Mater] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Interleukin-17 Enhances Immunosuppression by Mesenchymal Stem Cells
Scientists examined the effect of interleukin-17 (IL-17) on mesenchymal stem cells (MSCs) under the influence of inflammatory cytokines. Ironically, IL-17 dramatically enhanced the immunosuppressive effect of MSCs induced by interferon-γ and tumor necrosis factor-α, revealing a novel role of IL-17 in immunosuppression. [Cell Death Differ] Full Article

Bone Marrow-Derived Clonal Mesenchymal Stem Cells Inhibit Ovalbumin-Induced Atopic Dermatitis
Using an ovalbumin-induced atopic dermatitis (AD) mouse model, researchers investigated whether mesenchymal stem cells (MSCs) can be used as therapeutics in AD. Clonal MSCs suppressed both T- and B-cell activation. [Cell Death Dis] Full Article

Inhibition of B-Cell Proliferation and Antibody Production by Mesenchymal Stromal Cells Is Mediated by T Cells
Scientists show that, both in healthy subjects and in patients, in vitro B-cell proliferation, plasma-cell differentiation and antibody production are inhibited by bone marrow-derived mesenchymal stromal cells (MSCs) when peripheral blood lymphocytes are stimulated with CpG, but not when sorted B cells are cultured with MSCs+CpG. [Stem Cells Dev] Abstract

Cell-Viability and Chondrogenic Differentiation Capability of Human Mesenchymal Stem Cells after Iron-Labelling with Iron Sucrose
Investigators determined effects on cell viability, traceability and chondrogenic differentiation of human mesenchymal stem cells after iron labelling with iron sucrose. [Stem Cells Dev] Abstract

Autologous Platelet Rich Plasma: A Biological Supplement to Enhance Adipose-Derived Mesenchymal Stem Cell Expansion
Adipose-derived mesenchymal stem cells (AT-MSCs) were cultured for ten days in media supplemented with different concentrations of autologous non-activated or thrombin-activated platelet-rich plasma. AT-MSC proliferation, cell phenotype, and multipotency capacity and chromosome stability were assessed and compared to AT-MSCs expanded in a classical medium supplemented with 10% of fetal bovine serum. [Tissue Eng Part C Methods] Abstract

Expansion of Human Mesenchymal Stromal Cells from Fresh Bone Marrow in a 3D Scaffold-Based System under Direct Perfusion
Scientists demonstrate that conventional monolayer culture on plastic dish mesenchymal stromal/stem cell expansion can be entirely bypassed by culturing freshly isolated bone marrow nucleated cells within three dimensional (3D) porous scaffolds in a perfusion-based bioreactor system. [PLoS One] Full Article

Enhanced Osteogenic Differentiation of Mesenchymal Stem Cells on Poly(L-Lactide) Nanofibrous Scaffolds Containing Carbon Nanomaterials
Carbon nanomaterials (CNM) were incorporated into nanofibrous poly(L-lactic acid) scaffolds by thermal induced phase separation. The CNM-containing composite nanofibrous scaffolds were biologically evaluated by both in vitro co-culture of bone mesenchymal stem cells and in vivo implantation. [J Biomed Mater Res A] Abstract

Overexpression of TGF-β1 Enhances Chondrogenic Differentiation and Proliferation of Human Synovium-Derived Stem Cells
Scientists investigated the effect of continuous transforming growth factor (TGF)-β1 overexpression in human synovium-derived mesenchymal stem cells (hSD-MSCs) on immunophenotype, differentiation potential, and proliferation rate. hSD-MSCs were transduced with recombinant retroviruses encoding TGF-β1. [Biochem Biophys Res Commun] Abstract

Neural Differentiation of Mesenchymal Stem Cells Influences Their Chemotactic Responses to Stromal Cell-Derived Factor-1α
Researchers demonstrated that mesenchymal stem cells in varying neural differentiation states display various chemotactic responses to stromal cell-derived factor-1α. [Cell Mol Neurobiol] Abstract

Frozen Adipose-Derived Mesenchymal Stem Cells Maintain High Capability to Grow and Differentiate
Scientists show that adipose-derived stromal cells in serum free media can easily be frozen and stored in liquid nitrogen with retention of 85% of cell viability and 180,890 cell/g yield plus normal proliferative capacity and differentiation potential compared with fresh controls. [Cryobiology] Full Article

A Novel Albumin-Based Tissue Scaffold for Autogenic Tissue Engineering Applications
Using a culture of human mesenchymal stem cells (MSCs) as a model, scientists showed that MSCs can be seeded and grown in the albumin tissue scaffold. Furthermore, the albumin tissue scaffold can support the long-term osteogenic differentiation of MSCs. [Sci Rep] Full Article

Achieve Superior Differentiation of Mouse MSC & MEF into Osteoblasts with the MesenCult™ Osteogenic Stimulatory Kit (Mouse)
Mesenchymal Stem Cells and Hypoxia: Where Are We?
The authors summarize recent knowledge on the survival of mesenchymal stromal cells (MSCs) under low oxygen conditions of varying duration and severity and to elucidate the mechanisms of MSC resistance/sensitivity to hypoxic impact. [Mitochondrion] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.
Osiris Expands Its Grafix® Product Portfolio and Launches Additional Sizes
Osiris Therapeutics, Inc. announced the addition of several new sizes to the Grafix® product line. Grafix, a cryopreserved placental membrane, is regulated under 21 CFR 1271, part 361, Human Cells, Tissues and Cellular Tissue-Products as a wound cover. [Osiris Therapeutics, Inc.] Press Release

Osteo Science Foundation Awards Nearly 200 Thousand Dollars in Research Grants
The Board of Directors of the Osteo Science Foundation has awarded its inaugural four research grants, totaling close to $200,000, to researchers at Columbia University, Indiana University, Rutgers University and UCLA. The research projects focus on applied developments and treatment concepts in regenerative medicine for clinical application in oral, cranial and maxillofacial surgery. [Osteo Science Foundation] Press Release

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National Institutes of Health (United States)

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Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW NYSCF New York Stem Cell Foundation 9th Annual Gala and Science Fair
October 14, 2014
New York City, New York

Visit our events page to see a complete list of events in the mesenchymal cell community.
NEW Product Marketing Manager (Cesca Therapeutics)

NEW Technical Account Manager (GlobalStem)

Postdoctoral Fellow – Crosstalk and Interactions between Skeletal Cells and the Blood Vessels of Bone (KU Leuven)

PhD Studentship – Effects of Aging on MSC Therapy Activity (Loughborough University)

PhD Position – Pericyte Function and Dysfunction in CNS Disease (Lund University)

Research Assistant / Associate Positions – Regenerative Medicine (University of Glasgow)

Postdoctoral Position – Mesenchymal Stem Cells (University of Southern California)

Instructor – Regulation of Stem Cell Differentiation in Vascular Disease (University of Alabama at Birmingham)

Postdoctoral Research Scholar – The Role of Mesenchymal Factors in Cancer Progression (Washington University School of Medicine)

Scientist – Mesenchymal Stem and Progenitor Cell Biology (STEMCELL Technologies Inc.)

Scientist – Myogenic Progenitor Cell Biology (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

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