Tenogenic Induction of Human MSCs by Anisotropically Aligned Collagen Biotextiles
A 3D-biotextile was woven purely from collagen. Mesenchymal stem cells (MSCs) seeded in the woven scaffold underwent tenogenic differentiation in the absence of growth factors and synthesized a matrix that is positive for tenomodulin, COMP and type I collagen. [Adv Funct Mater]
Abstract
Interleukin-17 Enhances Immunosuppression by Mesenchymal Stem Cells
Scientists examined the effect of interleukin-17 (IL-17) on mesenchymal stem cells (MSCs) under the influence of inflammatory cytokines. Ironically, IL-17 dramatically enhanced the immunosuppressive effect of MSCs induced by interferon-γ and tumor necrosis factor-α, revealing a novel role of IL-17 in immunosuppression. [Cell Death Differ]
Full Article
Autologous Platelet Rich Plasma: A Biological Supplement to Enhance Adipose-Derived Mesenchymal Stem Cell Expansion
Adipose-derived mesenchymal stem cells (AT-MSCs) were cultured for ten days in media supplemented with different concentrations of autologous non-activated or thrombin-activated platelet-rich plasma. AT-MSC proliferation, cell phenotype, and multipotency capacity and chromosome stability were assessed and compared to AT-MSCs expanded in a classical medium supplemented with 10% of fetal bovine serum. [Tissue Eng Part C Methods]
Abstract
Mesenchymal Stem Cells and Hypoxia: Where Are We?
The authors summarize recent knowledge on the survival of mesenchymal stromal cells (MSCs) under low oxygen conditions of varying duration and severity and to elucidate the mechanisms of MSC resistance/sensitivity to hypoxic impact. [Mitochondrion]
Abstract
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INDUSTRY NEWS
Osiris Expands Its Grafix® Product Portfolio and Launches Additional Sizes
Osiris Therapeutics, Inc. announced the addition of several new sizes to the Grafix® product line. Grafix, a cryopreserved placental membrane, is regulated under 21 CFR 1271, part 361, Human Cells, Tissues and Cellular Tissue-Products as a wound cover. [Osiris Therapeutics, Inc.]
Press Release
Osteo Science Foundation Awards Nearly 200 Thousand Dollars in Research Grants
The Board of Directors of the Osteo Science Foundation has awarded its inaugural four research grants, totaling close to $200,000, to researchers at Columbia University, Indiana University, Rutgers University and UCLA. The research projects focus on applied developments and treatment concepts in regenerative medicine for clinical application in oral, cranial and maxillofacial surgery. [Osteo Science Foundation]
Press Release
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