Volume 6.30 | Aug 12

Mesenchymal Cell News 6.30 August 12, 2014
Mesenchymal Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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Mesenchymal Stem Cells Maintain Blood-Brain Barrier Integrity by Inhibiting Aquaporin-4
Up-Regulation after Cerebral Ischemia

Scientists investigated whether mesenchymal stem cell therapy protects blood-brain barrier (BBB) integrity and explored the molecular mechanisms of aquaporin-4 on BBB integrity. [Stem Cells] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
GEF-H1 Controls Focal Adhesion Signaling that Regulates Mesenchymal Stem Cell Lineage Commitment
It is well-recognized that stimuli for osteogenesis of mesenchymal stem cells (MSCs) drive focal adhesions (FA) maturation, actin organization, and stress-fiber polarization. Scientists further explored the extent to which FA-mediated signals regulated by the FA protein composition specifies MSC commitment. [J Cell Sci]
Full Article

Mesenchymal Stem Cells Inhibit Lipopolysaccharide-Induced Inflammatory Responses of BV2 Microglial Cells through TSG-6
Researchers investigated the anti-inflammatory effects of mesenchymal stem cells and TNF-alpha stimulated gene/protein 6 (TSG-6) in an in vitro lipopolysaccharide-induced BV2 microglial activation model.
[J Neuroinflammation]
Full Article

Viability of Equine Mesenchymal Stem Cells during Transport and Implantation
Efficient transfer of mesenchymal stem cells from the laboratory into tissue requires well-validated transport and implantation techniques. Cell viability in a range of media was determined over 72 hours and after injection through a 19G, 21G or 23G needle. [Stem Cell Res Ther] Abstract | Full Article

Human Umbilical Cord Mesenchymal Stem Cells and Derived Hepatocyte-Like Cells Exhibit Similar Therapeutic Effects on an Acute Liver Failure Mouse Model
Investigators used a D-galactosamine plus lipopolysaccharide-induced acute liver failure mouse model to compare the therapeutic effects of human umbilical cord mesenchymal stem cells before and after induction of differentiation into hepatocyte. [PLoS One] Full Article

CD4+CD25 + Regulatory T Cells Are Not Required for Mesenchymal Stem Cell Function in Fully MHC-Mismatched Mouse Cardiac Transplantation
By using C57BL/6 mouse mesenchymal stem cells (MSCs), scientists discovered that mesenchymal stem cells suppressed CD4+ T cell proliferation and prolonged mouse cardiac allograft survival in a dose-dependent and non-major histocompatibility complex (MHC)-restricted manner. [Cell Tissue Res] Abstract

Patient-Tailored Application for Duchene Muscular Dystrophy on Mdx Mice Based Induced Mesenchymal Stem Cells
Researchers examined alternative methods for mesenchymal stem cells (MSC) production and showed that induced pluripotent stem cells may be differentiated into MSCs following exposure to SB431542.
[Exp Mol Pathol]

Up-Regulation of CXCR4 in Rat Umbilical Mesenchymal Stem Cells Induced by Serum from Rat with Acute Liver Failure Promotes Stem Cells Migration to Injured Liver Tissue
Investigators evaluated rat umbilical mesenchymal stem cells on C-X-C chemokine receptor type 4 (CXCR4) expression and homing to injured liver tissue. [Mol Cell Biochem] Abstract

Proliferation and Differentiation of Human Adipose-Derived Mesenchymal Stem Cells (ASCs) into Osteoblastic Lineage are Passage Dependent
Scientists examined serial subcultivation with expansion on the ability of ASCs to grow and differentiate into osteoblastic lineages. [Inflamm Res] Abstract

Technical Bulletin: Assays For Cord Blood
MSCs and Hyaluronan: Sticking Together for New Therapeutic Potential?
The authors review recent data suggesting the involvement of hyaluronic acid (HA) in the beneficial effects of mesenchymal multipotent/stem/progenitor/stromal/marrow cells (MSCs), and evaluate the potential of MSC as modulators of HA and the implications of this modulation for disease therapy. [Int J Biochem Cell Biol] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.
National Institutes of Health and Mesoblast Enter into Agreement for 120-Patient Trial in End-Stage Heart Failure
Mesoblast Limited announced the signing of an agreement with the National Institutes of Health’s National Heart, Lung and Blood Institute to collaborate on a trial using Mesoblast’s proprietary adult stem cell therapy to treat patients with advanced heart failure requiring an implantable left ventricular assist device to maintain circulatory support. [Mesoblast Ltd.] Download Press Release

Cedars-Sinai Heart Institute Opens First-of-Its-Kind Research Stem Cell Clinic for Cardiac Patients
Regenerative medicine experts at the Cedars-Sinai Heart Institute have opened a new clinic to evaluate heart and vascular disease patients for participation in stem cell medical studies.
[Cedars-Sinai Medical Center (Newswire LLC)]
Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW XXII Congress of the European Society of Gene and Cell Therapy 2014 (ESGCT)
October 23-26, 2014
The Hague, The Netherlands

Visit our events page to see a complete list of events in the mesenchymal cell community.
NEW Postdoctoral Fellow – Intestinal Immunology (BSRC Fleming)

Postdoctoral Position – Biomaterials/Cartilage Regeneration (Peking University)

Cell Biology Technician (University of Pittsburgh School of Medicine)

Postdoctoral Fellowship – Developing Applications of Mesenchymal Stromal/Stem Cells in Hematopoietic Cell Transplantation (The Research Institute at Nationwide Children’s Hospital)

Postdoctoral Positions – Tissue Engineering and Regenerative Medicine (University of the Andes)

Technical Account Manager (GlobalStem)

Postdoctoral Fellow – Crosstalk and Interactions between Skeletal Cells and the Blood Vessels of Bone (KU Leuven)

PhD Position – Pericyte Function and Dysfunction in CNS Disease (Lund University)

Scientist – Mesenchymal Stem and Progenitor Cell Biology (STEMCELL Technologies Inc.)

Scientist – Myogenic Progenitor Cell Biology (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

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