“Mesenchymal” Stem Cells|
Two opposing descriptions of so-called mesenchymal stem cells (MSCs) exist at this time. One sees MSCs as the postnatal, self-renewing, and multipotent stem cells for the skeleton. In the alternative description, MSCs are ubiquitous in connective tissues and are defined by in vitro characteristics and by their use in therapy, which rests on their ability to modulate the function of host tissues rather than on stem cell properties. The author discusses how the two views developed, conceptually and experimentally, and attempt to clarify the confusion arising from their collision. [Annu Rev Cell Dev Biol]
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