Volume 6.33 | Sept 2

Mesenchymal Cell News 6.33 September 2, 2014
Mesenchymal Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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Neovascularization Capacity of Mesenchymal Stromal Cells from Critical Limb Ischemia Patients Is Equivalent to Healthy Controls
Investigators compared critical limb ischemia-mesenchymal stromal cells to healthy controls using gene expression profiling and functional assays for differentiation, senescence and in vitro and in vivo pro-angiogenic ability. [Mol Ther] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
P2X7-Induced Zeiosis Promotes Osteogenic Differentiation and Mineralization of Postmenopausal Bone Marrow-Derived Mesenchymal Stem Cells
Scientists investigated the role of the P2X7 receptor on osteogenic differentiation and mineralization of bone marrow mesenchymal stem cell cultures from postmenopausal women. [FASEB J] Abstract

Influence of Insulin-Like Growth Factor I Overexpression via Recombinant Adeno-Associated Vector Gene Transfer upon the Biological Activities and Differentiation Potential of Human Bone Marrow-Derived Mesenchymal Stem Cells
Investigators examined the potential benefits of sustained overexpression of the mitogenic and pro-anabolic insulin-like growth factor I via gene transfer upon the biological activities of human mesenchymal stem cells. [Stem Cell Res Ther] Abstract | Full Article

Novel Daidzein Analogs Enhance Osteogenic Activity of Bone Marrow-Derived Mesenchymal Stem Cells and Adipose-Derived Stromal/Stem Cells through Estrogen Receptor Dependent and Independent Mechanisms
Scientists explored the effects of daidzein analogs on the osteogenic differentiation efficiency of human bone marrow-derived mesenchymal stem cells and adipose-derived stromal/stem cells. [Stem Cell Res Ther]
| Full Article

TNFalpha and IL-1beta Influence the Differentiation and Migration of Murine MSCs Independently of the NF-kappaB Pathway
The authors determined if pro-inflammatory cytokines altered the differentiation and migration capacity of murine mesenchymal stem cells (MSCs) from different mouse strains and if this was mediated by NF-kappaB.
[Stem Cell Res Ther]
Abstract | Full Article

Umbilical Cord Mesenchymal Stem Cells Inhibit the Differentiation of Circulating T Follicular Helper Cells in Patients with Primary Sjögren’s Syndrome through the Secretion of Indoleamine 2,3-Dioxygenase
Researchers investigated the effect of umbilical cord mesenchymal stem cells on circulating T follicular helper cells in primary Sjögren’s Syndrome patients. [Rheumatology] Abstract

Systemic Infusion of Mesenchymal Stem Cells Improves Cell-Based Bone Regeneration via Upregulation of Regulatory T Cells
Investigators showed that bone marrow mesenchymal stem cells (BMMSCs) possessed an immunomodulatory function in vitro and that systemic BMMSC infusion significantly improved cell-based repair of critical-sized calvarial defects in a murine model. [Tissue Eng Part A] Abstract

Mesenchymal Stem/Progenitor Cell Isolation from Tooth Extraction Sockets
Researchers identified and characterized a population of stem/progenitor cells in granulation tissue obtained from the dental socket that exhibited several characteristics similar to those of bone marrow-derived mesenchymal stem/progenitor cells. [J Dent Res] Abstract

Reconstruction of Beagle Hemi-Mandibular Defects with Allogenic Mandibular Scaffolds and Autologous Mesenchymal Stem Cells
Scientists tested whether treatment of graft with mesenchymal stem cells can increase the integration of massive allografts (hemi-mandible) in a large animal model. [PLoS One] Full Article

Improved Quality of Cartilage Repair by Bone Marrow Mesenchymal Stem Cells for Treatment of an Osteochondral Defect in a Cynomolgus Macaque Model
Researchers investigated whether incorporation of mesenchymal stem cells into the collagen scaffold improves integration and repair of cartilage defects in a cynomolgus macaque model. [Acta Orthop] Full Article

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The Role of Catecholamines in Mesenchymal Stem Cell Fate
The authors describe the current state of catecholamines in mesenchymal stem cells destination and discuss strategies being used for catecholamines for migration of these cells to damaged tissues. [Cell Tissue Res] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

Cell Culture World Congress Asia 2014
Cellular Biomedicine Group Launches Clinical Research Study for Cartilage Defect Stem Cell Therapy
Cellular Biomedicine Group Inc. announced the launch of a study on human adipose derived mesenchymal progenitor cell therapy for cartilage defects resulting from osteoarthritis or sports injury. [Cellular Biomedicine Group Inc.] Press Release

Treatment with Aastrom’s Ixmyelocel-T Shown to Reduce Incidence of Major Adverse Cardiovascular Events in Patients with Ischemic Dilated Cardiomyopathy
Aastrom Biosciences, Inc. announced that results from the company’s Phase IIa clinical studies of ixmyelocel-T for the treatment of advanced heart failure due to ischemic dilated cardiomyopathy. [Aastrom Biosciences, Inc.] Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW The Australasian Society for Stem Cell Research (ASSCR) Meeting 2014
November 9-11, 2014
Lorne, Australia

NEW Clinical Applications of Stem Cells (CASC) 2015
February 26-27, 2015
Singapore, Singapore

Visit our events page to see a complete list of events in the mesenchymal cell community.
NEW Research Assistant – Umbilical Mesenchymal Stem Cells (University of Cincinnati)

NEW Postdoctoral Position – Intestinal Immunology (BSRC Fleming)

Mesenchymal Stromal/Stem Cell Scientist (UHN Arthritis Program)

Researcher – Phenotypic and Functional Characterization of Adult Stem/Stromal Cells from Bone Marrow and Adipose Tissue (Etablissement Français du Sang Pyrénées-Méditerranée)

PhD Position – Tissue Engineering and Stem Cell Biology (Dublin City University)

Postdoctoral Fellow – Intestinal Immunology (BSRC Fleming)

Postdoctoral Position – Biomaterials/Cartilage Regeneration (Peking University)

Postdoctoral Fellowship – Developing Applications of Mesenchymal Stromal/Stem Cells in Hematopoietic Cell Transplantation (The Research Institute at Nationwide Children’s Hospital)

Scientist – Mesenchymal Stem and Progenitor Cell Biology (STEMCELL Technologies Inc.)

Scientist – Myogenic Progenitor Cell Biology (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

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