Volume 6.35 | Sep 16

Mesenchymal Cell News 6.35 September 16, 2014
Mesenchymal Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Transient Vascularization of Transplanted Human Adult-Derived Progenitors Promotes Self-Organizing Cartilage
Scientists demonstrate efficient regeneration of avascular elastic cartilage from in vitro-grown mesenchymal condensation, which recapitulated the early stages of chondrogenesis, including transient vascularization. [J Clin Invest] Full Article
SmartDish™ with STEMgrid™-6 for Accurate Counting of Hematopoietic CFU Assays
 
PUBLICATIONS (Ranked by impact factor of the journal)
Metabolic Programming of Mesenchymal Stromal Cells by Oxygen Tension Directs Chondrogenic Cell Fate
Researchers prove that metabolic programming of mesenchymal stromal cells (MSCs) by oxygen tension directs chondrogenesis into either permanent or transient hyaline cartilage. Human MSCs chondrogenically differentiated in vitro under hypoxia produced more hyaline cartilage, which expressed typical articular cartilage biomarkers, including established inhibitors of hypertrophic differentiation. [Proc Natl Acad Sci USA] Abstract

Scaffold Mean Pore Size Influences Mesenchymal Stem Cell Chondrogenic Differentiation and Matrix Deposition
Scientists investigated whether scaffold mean pore sizes affects mesenchymal stem cell initial attachment, morphology, chondrogenic gene expression and cartilage-like matrix deposition. [Tissue Eng Part A] Abstract

A Novel Method for Differentiation of Human Mesenchymal Stem Cells into Smooth Muscle-Like Cells on Clinically Deliverable TIPS Microspheres
Scientists report the use of highly porous microcarriers produced using thermally induced phase separation (TIPS) to expand and differentiate adipose-derived mesenchymal stem cells into smooth muscle-like cells in a format that requires minimal manipulation before clinical delivery. [Tissue Eng Part C Methods] Abstract

Gene Expression Profile Analysis of Human Mesenchymal Stem Cells from Herniated and Degenerated Intervertebral Discs Reveals Different Expression of Osteopontin
Researchers present a characterization of mesenchymal stem cells (MSCs) isolated from clinically-categorized herniated (H-IVD) and degenerated (D-IVD) disc samples. H-IVD-MSCs and D-IVD-MSCs showed multipotent mesenchymal differentiation ability, expressing positivity for adipogenic, osteogenic, and chondrogenic markers with an immunophenotypical profile representative of MSCs. [Stem Cells Dev] Abstract

Novel Hedgehog Agonists Promote Osteoblast Differentiation in Mesenchymal Stem Cells
The authors demonstrate that hedgehog-Ag 1.3 and 1.7 strongly activate the expression of endogenous Gli1 and promote osteoblast differentiation in the mesenchymal stem cell line C3H10T1/2. [J Cell Physiol] Abstract

Decreased SIRT3 in Aged Human Mesenchymal Stromal/Stem Cells Increases Cellular Susceptibility to Oxidative Stress
Researchers show that severe oxidative stress reduces sirtuin3 (SIRT3) levels in young human mesenchymal stromal/stem cells (hMSCs). Overexpression of SIRT3 improved hMSCs resistance to the detrimental effects of oxidative stress. [J Cell Mol Med] Full Article

Effects of Negative Pressure Wound Therapy on Mesenchymal Stem Cells Proliferation and Osteogenic Differentiation in a Fibrin Matrix
Researchers investigated the effects of negative pressure wound therapy on rat periosteum-derived mesenchymal stem cells proliferation and osteoblastic differentiation in a 3D fibrin matrix. [PLoS One]
Full Article

Mangiferin Reduces the Inhibition of Chondrogenic Differentiation by IL-1β in Mesenchymal Stem Cells from Subchondral Bone and Targets Multiple Aspects of the Smad and SOX9 Pathways
Scientists determined the effect of mangiferin on chondrogenic differentiation in IL-1β-stimulated mesenchymal stem cells from subchondral bone and to explore the mechanisms underlying these effects. [Int J Mol Sci] Abstract | Download Full Article

The Influence of IL-10 and TNFα on Chondrogenesis of Human Mesenchymal Stromal Cells in Three-Dimensional Cultures
Scientists determined the effectiveness of two three-dimensional (3D) culture systems for chondrogenic mesenchymal stromal cell (MSC) differentiation in comparison to primary chondrocytes and to assess the effect of Interleukin (IL)-10 and Tumor Necrosis Factor (TNF)α on chondrogenesis by MSCs in 3D high-density culture. [Int J Mol Sci] Abstract | Download Full Article

Human Bone Marrow Stromal Cells Lose Immunosuppressive and Anti-Inflammatory Properties upon Oncogenic Transformation
Using sequentially mutated human bone marrow stromal cells (hBMSCs) and spontaneously transformed hBMSCs, scientists report that, upon oncogenic transformation, hBMSCs lose immunosuppressive and anti-inflammatory properties in vitro and in vivo. [Stem Cell Rep] Full Article

Learn How to Assemble & Purge the Hypoxia Chamber Watch the Video
 
REVIEWS
Cell-Based Therapy for Acute Organ Injury: Preclinical Evidence and Ongoing Clinical Trials Using Mesenchymal Stem Cells
The authors review the biological capabilities of mesenchymal stem or stromal cells (MSCs) and the results of clinical trials using MSCs as therapy in acute organ injuries. [Anesthesiology] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.
 
INDUSTRY NEWS
Bone Therapeutics Receives Clearance for ALLOB® Phase II Trial in Spinal Fusion
Bone Therapeutics announce that it has received clearance from the Competent Authorities and Central Ethics Committee in Belgium for a Phase II proof-of-concept study to assess safety and efficacy of its allogeneic osteoblastic cell therapy product ALLOB® in spinal fusion procedures for degenerative lumbar disc disease. [Bone Therapeutics S.A.] Press Release

MEDIPOST America Clears Phase I/II IND for the U.S. Clinical Trial on Stem Cell Drug for Lung
MEDIPOST America Inc. announced the US FDA approval of Phase I/II clinical trial for PNEUMOSTEM®. PNEUMOSTEM® is made from allogeneic human umbilical cord blood-derived mesenchymal stem cells, and is expected to have effect on regenerating the lung tissue and improving inflammatory responses in premature infants. [MEDIPOST America Inc. (Business Wire)] Press Release

From our sponsor: Pluripotent cell isolation for regenerative medicine. Request a free wallchart from Nature.
 
POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW 3rd Annual Cell Culture & Bioprocessing Congress
November 20-21, 2014
London, United Kingdom

Visit our events page to see a complete list of events in the mesenchymal cell community.
 
JOB OPPORTUNITIES
NEW PhD Position – Mitochondrial Disorders (University Children´s Hospital)

NEW Junior Scientist – Multiple Myeloma (University Clinic Hamburg-Eppendorf)

NEW Postdoctoral Position – Cardiopulmonary Molecular Biology (Hannover Medical School)

Mesenchymal Stem/Stromal Cells Characterization (INSERM)

Mesenchymal Stromal/Stem Cell Scientist (UHN Arthritis Program)

Researcher – Phenotypic and Functional Characterization of Adult Stem/Stromal Cells from Bone Marrow and Adipose Tissue (Etablissement Français du Sang Pyrénées-Méditerranée)

Postdoctoral Position – Biomaterials/Cartilage Regeneration (Peking University)

Postdoctoral Fellowship – Developing Applications of Mesenchymal Stromal/Stem Cells in Hematopoietic Cell Transplantation (The Research Institute at Nationwide Children’s Hospital)

Scientist – Mesenchymal Stem and Progenitor Cell Biology (STEMCELL Technologies Inc.)

Scientist – Myogenic Progenitor Cell Biology (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)


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