Tenascin-C Mimetic Peptide Nanofibers Direct Stem Cell Differentiation to Osteogenic Lineage
Investigators achieved control of stem cell fate towards osteogenic commitment by using a single extracellular matrix element despite the contradictory effect of mechanical stiffness. When rat mesenchymal stem cells were cultured on peptide nanofibers, ALP activity and alizarin red staining indicated osteogenic differentiation even in the absence of osteogenic supplements. [Biomacromolecules] Abstract
Prospective Heterotopic Ossification Progenitors in Adult Human Skeletal Muscle
Adherent cells from freshly digested skeletal muscle tissue were expanded in defined culture medium and were FACS-enriched for the CD73+CD105+CD90− population, which displayed robust multilineage potential. In addition to differentiating into typical heterotopic ossification lineages, human muscle resident mesenchymal stromal cells also differentiated into brown adipocytes expressing uncoupling protein 1. [Bone] Full Article
The Key Role of PML in IFN-α Induced Cellular Senescence of Human Mesenchymal Stromal Cells
Scientists investigated the effects of interferon α (IFN-α) on human mesenchymal stromal cells (hMSCs) and defined the role of PML involved in this process. Their results suggested that hMSCs incurred senescence upon IFN-α stimulation, while PML levels were observed significant increased. [Int J Oncol] Abstract
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