Volume 6.44 | Nov 25

Mesenchymal Cell News 6.44 November 25, 2014
Mesenchymal Cell News
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Endogenous Mesenchymal Stromal Cells in Bone Marrow Are Required to Preserve Muscle Function in Mdx Mice
Transplantation of bone marrow cells (BMCs) from 10-week-old Duchenne muscular dystrophy mice (mdx) into three-to-four-week-old mdx mice increased inflammation and fibrosis and reduced muscle function compared with mdx mice that received BMCs from 10-week-old wild-type mice, suggesting that the alteration of BMC populations in mdx mice affects the progression of muscle pathology. [Stem Cells] Abstract
Achieve Superior Differentiation of Mouse MSC & MEF into Osteoblasts with the MesenCult™ Osteogenic Stimulatory Kit (Mouse)
PUBLICATIONS (Ranked by impact factor of the journal)
Aging Disrupts Cell Subpopulation Dynamics and Diminishes the Function of Mesenchymal Stem Cells
Scientists utilized single cell transcriptional analysis to determine the effect of aging on mesenchymal stem cell (MSC) population dynamics. They identified an age-related depletion of a subpopulation of MSCs characterized by a pro-vascular transcriptional profile. [Sci Rep] Full Article

Safety and Neurological Assessments after Autologous Transplantation of Bone Marrow Mesenchymal Stem Cells in Subjects with Chronic Spinal Cord Injury
Researchers evaluated the feasibility, safety and potential efficacy of autologous transplantation of mesenchymal stem cells in subjects with chronic complete spinal cord injury (SCI). They conducted a Phase I, non-controlled study in 14 subjects of both genders aging between 18 to 65 years, with chronic traumatic SCI. [Stem Cell Res Ther] Abstract | Full Article

MicroRNA-378 Promotes Mesenchymal Stem Cells Survival and Vascularization under Hypoxic-Ischemic Condition In Vitro
Scientists investigated the influence of microRNA-378 transfection on mesenchymal stem cells survival and vascularization under hypoxic-ischemic condition in vitro. [Stem Cell Res Ther] Abstract | Full Article

Anti-Inflammatory/Tissue Repair Macrophages Enhance the Cartilage-Forming Capacity of Human Bone Marrow-Derived Mesenchymal Stromal Cells
Researchers investigated whether macrophages with, respectively, pro-inflammatory and tissue-remodeling traits differentially modulate chondrogenesis of bone marrow derived-mesenchymal stem/stromal cells. [J Cell Physiol] Abstract

Bone Marrow Regeneration Promoted by Biophysically Sorted Osteoprogenitors from Mesenchymal Stromal Cells
By leveraging biophysical traits of mesenchymal stromal cell (MSC) subpopulations and label-free microfluidic cell sorting, scientists hypothesized and experimentally verified that MSCs of large diameter within expanded MSC cultures were osteoprogenitors that exhibited significantly greater efficacy over other MSC subpopulations in bone marrow repair. [Stem Cells Transl Med] Abstract

Hypoxia-Controlled EphA3 Marks a Human Endometrium-Derived Multipotent Mesenchymal Stromal Cell that Supports Vascular Growth
Scientists discovered the hypoxia inducible factor-1α-controlled expression of EphA3, an Eph family member with critical functions during human tumor progression, in the vascularized tissue of regenerating human endometrium and on isolated human endometrial multipotent mesenchymal stromal cells, but not in other highly vascularized human organs. [PLoS One] Full Article

Differentiated Mesenchymal Stem Cells Ameliorate Cardiovascular Complications in Diabetic Rats
Bone marrow mesenchymal stem cells (MSCs) differentiated to insulin-secreting β-cells were used to treat STZ-induced diabetic rats. The post-homing effects of the differentiated MSCs were endogenous with definite reversal of diabetic parameters. [Cell Tissue Res] Abstract

Functionally Deficient Mesenchymal Stem Cells Reside in the Bone Marrow Niche with M2-Macrophages and Amyloid-β Protein Adjacent to Loose Total Joint Implants
Researchers sought to demonstrate whether there is a difference in the local mesenchymal stem cell niche obtained from patients undergoing their first total joint replacement surgery versus those patients undergoing a revision surgery for an failing total joint implant. [J Orthop Res] Abstract

Chondroitin Sulfate Microparticles Modulate Transforming Growth Factor-β1-Induced Chondrogenesis of Human Mesenchymal Stem Cell Spheroids
Scientists examined the effects of incorporating chondroitin sulfate methacrylate microparticles within small mesenchymal stem cells spheroids cultured in the presence of transforming growth factor-β1 on chondrogenesis. [Cells Tissues Organs] Full Article

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MicroRNAs as Regulators of Adipogenic Differentiation of Mesenchymal Stem Cells
A number of recent studies have reported several microRNAs (miRNAs) that enhance or inhibit adipogenic differentiation of mesenchymal stem cells (MSCs) and with potential use in microRNA-based therapy to regulate adipogenesis in the context of treating bone diseases and metabolic disorders. This review focuses on miRNAs and their role in regulating adipogenic differentiation of MSCs. [Stem Cells Dev] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.
Remotely Controlled Magnetic Nanoparticles Stimulate Stem Cells to Regenerate Bones
Researchers in bone tissue regeneration believe they have made a significant breakthrough for sufferers of bone trauma, disease or defects such as osteoporosis. Medical researchers from Keele University and Nottingham University have found that magnetic nanoparticles coated with targeting proteins can stimulate stem cells to regenerate bone. [Keele University] Article

Cord Blood Registry Sponsors 2014 World Stem Cell Summit
Cord Blood Registry® announced that the company is a platinum sponsor of the 10th Annual World Stem Cell Summit, the largest global meeting of stem cell science and regenerative medicine stakeholders. [Cord Blood Registry®] Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Keystone Symposium – Endoderm Lineages in Development and Disease
February 8-13, 2015
Keystone, United States

Visit our events page to see a complete list of events in the mesenchymal cell community.
NEW Mesenchymal Stem Cell (MSC) Laboratory Technician (California Cryobank)

NEW Clinical Laboratory Scientist – Umbilical Cord Blood Processing (California Cryobank)

Head of Cellular and Molecular Therapies Laboratory (NHS Blood & Transplant)

Animal Surgery – Regenerative Medicine for Cardiac and Skeletal Muscle Disease (Duke University)

Postdoctoral Fellow – Physiology and Pharmacology of Human Skeletal Muscle Microtissues (Duke University)

Postdoctoral Position – Therapeutic Potential of Mesenchymal Stem Cells (IRSN – French Nuclear Safety Institute)

Assistant/Associate Research Scientist – Bone Healing and Metabolism (New York University)

Postdoctoral Fellow – Collaborative Training Program in Musculoskeletal Health Research (Western University)

Quality Improvement Coordinator – Regenerative Medicine (The University of Texas Health Science Center at Houston)

Research Associate Position – Skeletal Research Center (Case Western Reserve University)

PhD Studentship – Biophysics and Mechanics of Stem Cells (Queen Mary University of London)

Scientist – Myogenic Progenitor Cell Biology (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

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