Volume 6.45 | Dec 2

Mesenchymal Cell News 6.45 December 2, 2014
Mesenchymal Cell News
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Mesenchymal Stromal Cells Form Vascular Tubes when Placed in Fibrin Sealant and Accelerate Wound Healing In Vivo
Researchers developed a fibrin formulation that allows adipose-derived mesenchymal stromal cells to form tubular structures in vitro. [Biomaterials] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Urokinase Type Plasminogen Activator Mediates Interleukin-17-Induced Peripheral Blood Mesenchymal Stem Cells Motility and Transendothelial Migration
Scientists studied the role of interleukin-17 (IL-17) on peripheral blood (PB) derived mesenchymal stem cells (MSCs) migration and transmigration across endothelial cells. IL-17 increased PB-MSCs migration in a wound healing assay as well as cell mobilization from collagen gel. [Biochim Biophys Acta] Abstract

Licochalcone A Up-Regulates of FasL in Mesenchymal Stem Cells to Strengthen Bone Formation and Increase Bone Mass
Researchers found that 0.35 mg/L licochalcone A had a strong effect in increasing the osteogenic differentiation and mineralization of bone marrow-derived mesenchymal stem cells both in vivo and in vitro by up-regulating FasL and further playing a role in regulating the ERK and GSK-3β-catenin systems. [Sci Rep] Full Article

A Decline in Wnt3a Signaling Is Necessary for Mesenchymal Stem Cells to Proceed to Replicative Senescence
Wnt/β-catenin signaling plays a functional role as a key regulator of self-renewal and differentiation in mesenchymal stem cells (MSCs), and thus Wnt/β-catenin signaling and cellular senescence might be closely connected. Scientists show that the expression levels of canonical Wnt families decrease as MSCs age during subculture. [Stem Cells Dev] Abstract

Randomized Placebo-Controlled Phase II Trial of Autologous Mesenchymal Stem Cells in Multiple Sclerosis
Uncontrolled studies of mesenchymal stem cells in multiple sclerosis suggested some beneficial effect. In this randomized, double-blind, placebo-controlled, crossover Phase II study researchers investigated their safety and efficacy in relapsing-remitting multiple sclerosis patients. [PLoS One] Full Article

Tissue Engineering of Rat Bladder Using Marrow-Derived Mesenchymal Stem Cells and Bladder Acellular Matrix
Researchers proposed the use of bladder acellular matrix seeded with marrow-derived mesenchymal stem cells for bladder tissue engineering. They optimized a protocol for decellularization of bladder tissue from different species including rat, rabbit and swine. [PLoS One] Full Article

Ovariectomized Rats with Established Osteopenia have Diminished Mesenchymal Stem Cells in the Bone Marrow and Impaired Homing, Osteoinduction and Bone Regeneration at the Fracture Site
Scientists investigated deleterious changes that take place in mesenchymal stem cells (MSC) and its fracture healing competence in ovariectomy (Ovx)-induced osteopenia. MSC from bone marrow of ovary intact and Ovx rats was isolated. Technetium hexamethylpropylene amine oxime labeled MSC was systemically transplanted to rats and fracture tropism assessed by SPECT/CT. [Stem Cell Rev] Abstract

Effect of T3 Hormone on Neural Differentiation of Human Adipose Derived Stem Cells
Researchers explored the effects of T3 treatment on neural differentiation of human adipose-derived stem cells (ADSCs). ADSCs were harvested from human adipose tissue, after neurosphere formation, and during final differentiation, treatment with T3 was performed. [Cell Biochem Funct] Abstract

Effects of Cartilage Oligomeric Matrix Protein on Bone Morphogenetic Protein-2-Induced Differentiation of Mesenchymal Stem Cells
Scientists used liposomes to transfect mesenchymal stem cells (MSCs) with plasmid encoding cartilage oligomeric matrix protein and then induced the transfected MSCs to differentiate in osteogenic and chondrogenic differentiation media containing BMP-2. [Orthop Surg] Abstract

Gene Expression of Tendon Markers in Mesenchymal Stromal Cells Derived from Different Sources
Scientists assessed and compared the expression of tendon extracellular matrix proteins and tendon differentiation markers in mesenchymal stromal cells (MSC) derived from different sources as well as in native tendon tissue. MSC isolated from equine bone marrow, adipose tissue, umbilical cord tissue, umbilical cord blood and tendon tissue were characterized and then subjected to mRNA analysis by real-time polymerase chain reaction. [BMC Research Notes] Full Article

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Implications for Human Adipose-Derived Stem Cells in Plastic Surgery
The authors examine the current landscape of adipose-derived stem cell (ADSC) isolation and identification, summarize the current applications of ADSCs in the field of plastic surgery, discuss the risks associated with their use, current barriers to universal clinical translatability, and survey the latest research which may help to overcome these obstacles. [J Cell Mol Med] Full Article

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

Don't miss ASGCT 18th Annual Meeting!
Pluristem Granted Patent in Singapore for its 3D Cell Expansion Technology
Pluristem Therapeutics Inc. announced it has been granted a patent in Singapore titled “Methods for Cell Expansion and Uses of Cells and Conditioned Media Produced Thereby for Therapy.” [Pluristem Therapeutics Inc.] Press Release

AlloSource® Celebrates 20 Years of Honoring the Gift of Human Tissue Donation
AlloSource is celebrating its 20th anniversary this month. The company has an array of new products, including fresh tissue for cartilage repair, meniscal tissue for transplant and AlloStem® Cellular Bone Allograft, partially demineralized allograft bone combined with adipose-derived mesenchymal stem cells. [AlloSource]
Press Release

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Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

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Therapeutic Goods Administration (Australia)
NEW Keystone Symposium – Endoderm Lineages in Development and Disease
February 8-13, 2015
Keystone, United States

Visit our events page to see a complete list of events in the mesenchymal cell community.
NEW PhD Studentship – Mesenchymal Stem Cells (University of York)

Mesenchymal Stem Cell (MSC) Laboratory Technician (California Cryobank)

Clinical Laboratory Scientist – Umbilical Cord Blood Processing (California Cryobank)

Head of Cellular and Molecular Therapies Laboratory (NHS Blood & Transplant)

Animal Surgery – Regenerative Medicine for Cardiac and Skeletal Muscle Disease (Duke University)

Postdoctoral Fellow – Physiology and Pharmacology of Human Skeletal Muscle Microtissues (Duke University)

Postdoctoral Position – Therapeutic Potential of Mesenchymal Stem Cells (IRSN – French Nuclear Safety Institute)

Assistant/Associate Research Scientist – Bone Healing and Metabolism (New York University)

Postdoctoral Fellow – Collaborative Training Program in Musculoskeletal Health Research (Western University)

Quality Improvement Coordinator – Regenerative Medicine (The University of Texas Health Science Center at Houston)

Scientist – Myogenic Progenitor Cell Biology (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

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