Volume 6.46 | Dec 9

Mesenchymal Cell News 6.46 December 9, 2014
Mesenchymal Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
miR-543 and miR-590-3p Regulate Human Mesenchymal Stem Cell Aging via Direct Targeting of AIMP3/p18
Scientists report a novel role of aminoacyl-tRNAsynthetase-interacting multifunctional protein-3 (AIMP3)/p18 in the cellular aging of human mesenchymal stem cells (hMSCs). They found that AIMP3/p18 expression significantly increased in senescent hMSCs and in aged mouse bone marrow-derived MSCs. [Age] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Human Mesenchymal Stem Cells Possess Different Biological Characteristics but Do Not Change Their Therapeutic Potential when Cultured in Serum Free Medium
Human umbilical cord mesenchymal stem cells (hUC-MSCs) were cultured in a chemical defined serum free medium. Growth, multipotency, surface antigen expression, telomerase, immunosuppressive ability, gene expression profile and genomic stability of hUC-MSCs cultured in serum free medium and serum-containing medium were analyzed and compared side by side. [Stem Cell Res Ther] Abstract | Full Article

Human Mesenchymal Stromal Cells Enhance the Immunomodulatory Function of CD8+CD28 Regulatory T Cells
Researchers studied the effects of mesenchymal stromal cells (MSCs) on CD8+CD28 regulatory T cells and found that the MSCs could not only increase the proportion of CD8+CD28 T cells, but also enhance CD8+CD28T cells’ ability of hampering naive CD4+ T-cell proliferation and activation, decreasing the production of IFN-γ by activated CD4+ T cells and inducing the apoptosis of activated CD4+ T cells. [Cell Mol Immunol] Full Article

Differential Expression of Basal MicroRNAs’ Patterns in Human Dental Pulp Stem Cells
Dental pulp stem cells (DPSCs) were characterized in terms of their proliferation and differentiation capacity. Scientists observed 19 up-regulated microRNAs (miRNAs) and 29 significantly down-regulated miRNAs in DPSCs in comparison with bone marrow mesenchymal stem cells. [J Cell Mol Med] Full Article

In Vitro Cell Motility as a Potential Mesenchymal Stem Cell Marker for Multipotency
Bone marrow mesenchymal stem cells from various donors and in vitro passages were evaluated for their in vitro motility, and the distances were correlated to the adipogenic, chondrogenic, and osteogenic differentiation potentials and the levels of senescence and cell size. [Stem Cells Transl Med] Abstract

Mesenchymal Stem Cells Promote Liver Regeneration and Prolong Survival in Small-For-Size Liver Grafts: Involvement of C-Jun N-Terminal Kinase, Cyclin D1, and NF-κB
Researchers explored whether and how mesenchymal stem cells protected hepatocytes and stimulated allograft regeneration in small-for-size liver transplantation. [PLoS One] Full Article

Local Delivery of Mesenchymal Stem Cells with Poly-Lactic-Co-Glycolic Acid Nano-Fiber Scaffold Suppress Arthritis in Rats
Mesenchymal stem cells seeded on nano-fiber scaffold suppressed arthritis and bone destruction due to inhibition of systemic inflammatory reaction and immune response by suppressing T cell proliferation and reducing anti- type II collagen antibody production. [PLoS One] Full Article

In Vitro Mutual Interaction between Tenocytes and Adipose-Derived Mesenchymal Stromal Cells
Scientists evaluated the in vitro mutual interaction of adipose-derived mesenchymal stromal cells and tenocytes in standard culture conditions and a microwound healing model. [Cytotherapy] Abstract

Randomized, Double-Blind, Phase I/II Study of Intravenous Allogeneic Mesenchymal Stromal Cells in Acute Myocardial Infarction
A Phase I/II randomized, double-blind, single-dose study was conducted to assess the safety and efficacy of intravenous administration of Stempeucel versus placebo. Twenty patients who had undergone percutaneous coronary intervention for acute myocardial infarction were randomly assigned to receive intravenous Stempeucel or placebo and were followed for two years. [Cytotherapy] Abstract

Co(II)-Mediated Effects of Plain and Plasma Immersion Ion Implanted Cobalt-Chromium Alloys on the Osteogenic Differentiation of Human Mesenchymal Stem Cells
Cobalt-chromium alloy modified by nitrogen plasma immersion ion implantation was evaluated with regard to its effect on the osteogenic differentiation of mesenchymal stem cells. [J Orthop Res] Abstract

Mesenchymal Stem Cell Spheroids Exhibit Enhanced In Vitro and In Vivo Osteoregenerative Potential
Investigators assessed whether the osteoregenerative potential of mesenchymal stem cell (MSC) spheroids is greater than that of monolayer MSCs. [BMC Biotechnol] Abstract | Full Article

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REVIEWS
Characteristics and Potential Applications of Human Dental Tissue-Derived Mesenchymal Stem Cells
The authors outline the properties of various dental mesenchymal stem cell-like populations and the progress toward their use in regenerative therapy. Several dental stem cell banks worldwide are also introduced, with a view toward future clinical application. [Stem Cells] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.
 
INDUSTRY NEWS
PMC Receives $100,000 Donation for Ongoing Stem Cell Research Program
Citing the need to invest in a long range cure, Roger Worthington of the Worthington & Caron, P.C. donated $100,000 to The Pacific Meso Center (PMC) at The Pacific Heart, Lung & Blood Institute to support its ongoing stem cell research program. [Pacific Heart Lung & Blood Institute] Article

Paul G. Allen to Give $100 Million to Create Cell Science Institute
Philanthropist and entrepreneur Paul G. Allen announced a commitment of $100 million to create the Allen Institute for Cell Science in Seattle. Founded to investigate and model the complex living machinery of cells, the nonprofit Allen Institute for Cell Science and its inaugural project, the Allen Cell Observatory, will accelerate disease research around the world by creating and sharing reagents, data and dynamic, predictive models of cells. [Allen Institute for Cell Science] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Tissue Engineering & Bioprinting: Research to Commercialization
February 9-10, 2015
Boston, United States

NEW Molecular Med Tri-Con 2015
February 15-20, 2015
San Francisco, United States

NEW Stem Cells in Drug Discovery
June 2-3, 2015
Cambridge, United Kingdom

Visit our events page to see a complete list of events in the mesenchymal cell community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Position – Epigenetic Regulation of Cell Fate and Metabolism (University Medical Center Freiburg)

NEW Postdoctoral Fellow – Cell Therapy and Bone Tissue Engineering (Etablissement Français du Sang Ile de France)

PhD Studentship – Mesenchymal Stem Cells (University of York)

Mesenchymal Stem Cell (MSC) Laboratory Technician (California Cryobank)

Clinical Laboratory Scientist – Umbilical Cord Blood Processing (California Cryobank)

Animal Surgery – Regenerative Medicine for Cardiac and Skeletal Muscle Disease (Duke University)

Postdoctoral Fellow – Physiology and Pharmacology of Human Skeletal Muscle Microtissues (Duke University)

Postdoctoral Position – Therapeutic Potential of Mesenchymal Stem Cells (IRSN – French Nuclear Safety Institute)

Assistant/Associate Research Scientist – Bone Healing and Metabolism (New York University)

Postdoctoral Fellow – Collaborative Training Program in Musculoskeletal Health Research (Western University)

Quality Improvement Coordinator – Regenerative Medicine (The University of Texas Health Science Center at Houston)

Scientist – Myogenic Progenitor Cell Biology (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)


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