Volume 7.00 | Jan 6

Mesenchymal Cell News 7.00 January 6, 2014
Mesenchymal Cell News
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MSCs Derived from iPSCs with a Modified Protocol Are Tumor-Tropic but Have Much Less Potential to Promote Tumors than Bone Marrow MSCs
Researchers derived mesenchymal stem or stromal cells (MSCs) from transgene-free human induced pluripotent stem cells (iPSCs) efficiently with a modified protocol that eliminated the need of flow cytometric sorting. These iPSC-derived MSCs homed to cancers with efficiencies similar to bone marrow (BM)-MSCs but were much less prone than BM-MSCs to promote the epithelial–mesenchymal transition, invasion, stemness, and growth of cancer cells. [Proc Natl Acad Sci USA] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
A Novel Collagen-Nanohydroxyapatite MicroRNA-Activated Scaffold for Tissue Engineering Applications Capable of Efficient Delivery of Both miR-Mimics and antagomiRs to Human Mesenchymal Stem Cells
Scientists introduced the first non-viral, non-lipid platform to date, capable of efficient delivery of mature microRNAs (miRNAs) molecules to human mesenchymal stem cells, a particularly difficult cell type to transfect effectively, with minimal treatment-associated cytotoxicity. [J Control Release] Abstract

Random Networks of Single-Walled Carbon Nanotubes Promote Mesenchymal Stem Cell’s Proliferation and Differentiation
The author demonstrated that the single-walled carbon nanotubes (SWCNT) Langmuir-Blodgett and network film based scaffolds do not show any cytotoxicity, while on the other hand, these scaffolds promote differentiation property of rat mesenchymal stem cells when compared with that on conventional tissue culture polystyrene substrates. [ACS Appl Mater Interfaces] Abstract

Effects of Mesenchymal Stem Cell Therapy, in Association with Pharmacologically Active Microcarriers Releasing VEGF, in Ischemic Stroke Model in the Rat
The effect of mesenchymal stem cell attached to laminin-pharmacologically active microcarriers, releasing or not vascular endothelial growth factor (VEGF), was evaluated in vivo in a model of transient stroke. [Acta Biomater] Abstract

Systemic Mesenchymal Stem Cell Administration Enhances Bone Formation in Fracture Repair but Not Load-Induced Bone Formation
Investigators questioned whether circulating mesenchymal stem cells (MSC) are recruited only in case of injury or whether they also participate in mechanically induced bone formation. To answer these questions, they injected green fluorescent protein-labelled MSC into C57BL/6J mice, which were subjected either to a femur osteotomy or to non-invasive mechanical ulna loading to induce bone formation. [Eur Cell Mater]
Abstract | Full Article

Influence of Culture Conditions and Extracellular Matrix Alignment on Human Mesenchymal Stem Cells Invasion into Decellularized Engineered Tissues
Scientists explored the influence of insulin and ascorbic acid and extracellular matrix alignment on the recellularization of decellularized engineered tissue by human mesenchymal stem cells. [J Tissue Eng Regen Med] Abstract

Chronic Spinal Cord Lesions Respond Positively to Transplants of Mesenchymal Stem Cells
Researchers investigated whether transplantation of mesenchymal stem cells in mice during the chronic stage of spinal cord injury has benefits in terms of morphological and functional outcomes. [Restor Neurol Neurosci] Abstract

CCR7 Expressing Mesenchymal Stem Cells Potently Inhibit Graft-versus-Host Disease by Spoiling the Fourth Supplemental Billingham’s Tenet
CCR7 gene was engineered into murine mesenchymal stem cells (MSCs) by lentivirus transfection system (MSCs/CCR7) and the immunomodulatory mechanism of MSCs/CCR7 was further investigated. [PLoS One] Full Article

Comparison of Human Induced Pluripotent Stem-Cell Derived Cardiomyocytes with Human Mesenchymal Stem Cells following Acute Myocardial Infarction
Researchers compared the therapeutic efficacy of human mesenchymal stem cells with human induced pluripotent stem cell-derived cardiomyocytes in mitigating myocardial infarction. [PLoS One] Full Article

Role of Wnt/β-Catenin Signaling in Epithelial Differentiation of Lung Resident Mesenchymal Stem Cells
Researchers explored the roles of Wnt/β-catenin signaling on cell proliferation and epithelial differentiation of lung resident mesenchymal stem cells (LR-MSCs). They also demonstrated the expression of epithelial markers on LR-MSCs following indirect co-culture of these cells with alveolar epithelial type II cells, confirming the epithelial phenotype of LR-MSCs following co-culture. [J Cell Biochem] Abstract

Statins Impair Survival of Primary Human Mesenchymal Progenitor Cells via Mevalonate Depletion, NF-κB Signaling, and Bnip3
Scientists examined the in vitro effects of three HMG-CoA reductase inhibitors atorvastatin, simvastatin, and pravastatin on the viability of mesenchymal stem cells and expression of nuclear factor kappa B (NF-κB). [J Cardiovasc Transl Res] Abstract

The Effect of Extended Passaging on the Phenotype and Osteogenic Potential of Human Umbilical Cord Mesenchymal Stem Cells
Investigators assessed morphology, viability, mesenchymal stem cells (MSC) marker expression, and osteogenic activity of human umbilical cord MSCs after extended passaging. [Mol Cell Biochem] Abstract

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The Multiple Functional Roles of Mesenchymal Stem Cells in Participating in Treating Liver Diseases
The authors review the capacity and molecular mechanism of mesenchymal stem cells (MSCs) transdifferentiation, and the therapeutic effects of MSCs on liver diseases. [J Cell Mol Med] Full Article

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.
BrainStorm Announces Final Analysis of Phase IIa ALS Study Showing Nearly All Subjects Experienced Clinical Benefit from NurOwn™
BrainStorm Cell Therapeutics Inc. announced positive final results from its Phase IIa clinical trial of NurOwn™ in amyotrophic lateral sclerosis (ALS) patients, which enrolled 14 subjects at Hadassah Medical Center in Jerusalem. [BrainStorm Cell Therapeutics Inc.] Press Release

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Philanthropists John and Leslie Malone Propel Regenerative Medicine with $42.5 Million Gift
Philanthropists John and Leslie Malone have committed a record $42.5 million to Colorado State University to develop regenerative medical therapies for animals and people. [Colorado State University] Press Release

Osiris Announces a Strategic Partnership with Stryker for Marketing Osiris’ Viable Bone Matrix
Osiris Therapeutics, Inc. announced that it has entered into an exclusive, worldwide partnership with Stryker Corporation for the commercialization and development of Osiris’ viable bone matrix tissue form. [Osiris Therapeutics, Inc.] Press Release
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Regenerative Medicine & Stem Cell 2015
March 19-21, 2015
Busan, South Korea

Visit our events page to see a complete list of events in the mesenchymal cell community.
NEW Postdoctoral Researcher – Stem Cell Biology (King Saud University)

NEW Postdoctoral Position – Stem Cell Engineering and Bioprocessing (Florida State University)

Postdoctoral Position – Morphogenetic Signaling Pathways in Development and Disease (University of Rochester Medical Center)

Postdoctoral Position – Epigenetic Regulation of Cell Fate and Metabolism (University Medical Center Freiburg)

Postdoctoral Fellow – Cell Therapy and Bone Tissue Engineering (Etablissement Français du Sang Ile de France)

PhD Studentship – Mesenchymal Stem Cells (University of York)

Mesenchymal Stem Cell (MSC) Laboratory Technician (California Cryobank)

Clinical Laboratory Scientist – Umbilical Cord Blood Processing (California Cryobank)

Scientist – Myogenic Progenitor Cell Biology (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

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