MSCs Derived from iPSCs with a Modified Protocol Are Tumor-Tropic but Have Much Less Potential to Promote Tumors than Bone Marrow MSCs
Researchers derived mesenchymal stem or stromal cells (MSCs) from transgene-free human induced pluripotent stem cells (iPSCs) efficiently with a modified protocol that eliminated the need of flow cytometric sorting. These iPSC-derived MSCs homed to cancers with efficiencies similar to bone marrow (BM)-MSCs but were much less prone than BM-MSCs to promote the epithelial–mesenchymal transition, invasion, stemness, and growth of cancer cells. [Proc Natl Acad Sci USA] Abstract
Role of Wnt/β-Catenin Signaling in Epithelial Differentiation of Lung Resident Mesenchymal Stem Cells
Researchers explored the roles of Wnt/β-catenin signaling on cell proliferation and epithelial differentiation of lung resident mesenchymal stem cells (LR-MSCs). They also demonstrated the expression of epithelial markers on LR-MSCs following indirect co-culture of these cells with alveolar epithelial type II cells, confirming the epithelial phenotype of LR-MSCs following co-culture. [J Cell Biochem] Abstract
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