Volume 7.01 | Jan 13

Mesenchymal Cell News 7.01 January 13, 2015
Mesenchymal Cell News
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Steering Stem Cell Trafficking into Pancreas Reverses Type 1 Diabetes
Researchers studying mesenchymal stem cells have uncovered a way to enhance and prolong the cells’ therapeutic effects in a preclinical model of type 1 diabetes. [Press release from Brigham and Women’s Hospital discussing publication in Stem Cells] Press Release | Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Necrotic Cell-Derived High Mobility Group Box 1 Attracts Antigen-Presenting Cells but Inhibits Hepatocyte Growth Factor-Mediated Tropism of Mesenchymal Stem Cells for Apoptotic Cell Death
Researchers investigated the influence of apoptotic and necrotic cell death on recruitment of mesenchymal stem cells, monocytes and immature dendritic cells, and identified hepatocyte growth factor and the alarmin high mobility group box 1 as key factors differentially regulating these migratory responses. [Cell Death Differ] Abstract

Diabetes Reduces Mesenchymal Stem Cells in Fracture Healing through a TNFα-Mediated Mechanism
Researchers examined the impact of diabetes on mesenchymal stem cells (MSCs) during fracture repair. Diabetes significantly increased TNFα levels and reduced MSC numbers in new bone area. [Diabetologia] Abstract

Unexpected Complication in a Rat Stroke Model: Exacerbation of Secondary Pathology in the Thalamus by Subacute Intraarterial Administration of Human Bone Marrow-Derived Mesenchymal Stem Cells
Scientists examined whether human bone marrow mesenchymal stromal/stem cells could alleviate the secondary pathology in the thalamus after middle cerebral artery occlusion in rats. [J Cereb Blood Flow Metab] Abstract

Synergistic Effect of Angiotensin II on Vascular Endothelial Growth Factor-A-Mediated Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells into Endothelial Cells
Scientists investigated a novel role of angiotensin signaling in enhancing vascular endothelial growth factor-A-mediated differentiation of mesenchymal stem cells into endothelial cells. [Stem Cell Res Ther]
Abstract | Full Article

Suspension-Expansion of Bone Marrow Results in Small Mesenchymal Stem Cells Exhibiting Increased Transpulmonary Passage following Intravenous Administration
Researchers explored whether the expansion of whole-marrow in suspension cultures would yield smaller mesenchymal stem cells with increased capacity to traverse the pulmonary microcirculation compared to traditional monolayer cultures. [Tissue Eng Part C Methods] Abstract

Crucial Role of IL1beta and C3a in the In Vitro-Response of Multipotent Mesenchymal Stromal Cells to Inflammatory Mediators of Polytrauma
Scientists investigated the effects of a defined serum-free polytrauma “cocktail” containing IL1beta, IL6, IL8 and the anaphylatoxins C3a and C5a, in concentrations corresponding to those measured in the blood of polytrauma patients, on human mesenchymal stromal cells in vitro. [PLoS One] Full Article

Multidifferentiation Potential of Human Mesenchymal Stem Cells from Adipose Tissue and Hamstring Tendons for Musculoskeletal Cell-Based Therapy
Human tendon stem/progenitor cells and adipose-derived stem cells were isolated from hamstring tendon portions and adipose tissue of healthy donors undergoing ACL reconstruction or liposuction, respectively. Clonogenic ability, immunophenotype and multi-differentiation potential were assessed and compared. [Regen Med] Abstract

Decellularized ECM Effects on Human Mesenchymal Stem Cell Stemness and Differentiation
Scientists addressed effects extracellular matrices (ECMs) deposited by a variety of cell types and decellularized with a cold-EDTA protocol have on multipotent human mesenchymal stromal/stem cell behavior and differentiation. [Differentiation] Abstract

Fucoidan Promotes Osteoblast Differentiation via JNK- and ERK-Dependent BMP2-Smad 1/5/8 Signaling in Human Mesenchymal Stem Cells
Researchers investigated the action of fucoidan on osteoblast differentiation in human alveolar bone marrow-derived mesenchymal stem cells and its impact on signaling pathways. [Exp Mol Med] Full Article

Calcitonin Gene-Related Peptide Stimulates Proliferation and Osteogenic Differentiation of Osteoporotic Rat-Derived Bone Mesenchymal Stem Cells
Researchers investigated the role of calcitonin gene-related peptide (CGRP) on bone mesenchymal stem cells (BMSCs) isolated from female osteoporotic rats. Data showed that CGRP stimulated cell proliferation and inhibited cell apoptosis for short-term culture of BMSCs. [Mol Cell Biochem] Abstract

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Stromal Cells and Stem Cells in Clinical Bone Regeneration
The authors highlight the successes and challenges reported in several clinical trials that involved the use of bone-marrow-derived mesenchymal or adipose-tissue-derived stromal cells. [Nat Rev Endocrinol] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.
BioRestorative Therapies Reports Successful Meeting with FDA
BioRestorative Therapies, Inc. announced that it has had a successful pre-investigational new drug meeting with the U.S. Food and Drug Administration (FDA) concerning its lead therapeutic product, brtxDISC™, to be used in a non-surgical treatment for chronic lumbar disc disease. [BioRestorative Therapies, Inc.]
Press Release

Cord Blood Registry and Cellular Dynamics International Announce Collaboration to Reprogram Newborn Stem Cells into Induced Pluripotent Stem Cells
Cord Blood Registry® (CBR®) and Cellular Dynamics International (CDI) announced that they have entered into a research collaboration to reprogram newborn stem cells from both umbilical cord blood and umbilical cord tissue collected, processed and cryopreserved under CBR’s protocols into induced pluripotent stem cells using CDI’s proprietary methods. [Cord Blood Registry (PR Newswire Association LLC)] Press Release

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Visit our events page to see a complete list of events in the mesenchymal cell community.
NEW Postdoctoral Fellow – Wnt Signaling in Development and Disease (Van Andel Research Institute)

NEW Postdoctoral Fellowship – CNS Inflammation (Rutgers University)

Postdoctoral Researcher – Stem Cell Biology (King Saud University)

Postdoctoral Position – Stem Cell Engineering and Bioprocessing (Florida State University)

Postdoctoral Position – Morphogenetic Signaling Pathways in Development and Disease (University of Rochester Medical Center)

Postdoctoral Position – Epigenetic Regulation of Cell Fate and Metabolism (University Medical Center Freiburg)

Postdoctoral Fellow – Cell Therapy and Bone Tissue Engineering (Etablissement Français du Sang Ile de France)

Mesenchymal Stem Cell (MSC) Laboratory Technician (California Cryobank)

Clinical Laboratory Scientist – Umbilical Cord Blood Processing (California Cryobank)

Scientist – Myogenic Progenitor Cell Biology (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

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