Volume 7.04 | Feb 3

Mesenchymal Cell News 7.04 February 3, 2015
Mesenchymal Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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Pulsed Focused Ultrasound Pretreatment Improves Mesenchymal Stem Cell Efficacy in Preventing and Rescuing Established Acute Kidney Injury In Mice
To examine the efficacy of pulsed focused ultrasound (pFUS)-enhanced cell homing in disease, investigators targeted pFUS to kidneys to enhance mesenchymal stem cell homing after cisplatin-induced acute kidney injury. [Stem Cells] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Chromatin Changes at the PPAR-γ2 Promoter during Bone Marrow-Derived Multipotent Stromal Cell Culture Correlate with Loss of Gene Activation Potential
Researchers used chromatin immunoprecipitation to compare post-translationally modified histones at a subset of gene promoters associated with developmental and environmental plasticity in bone marrow-derived multipotent stromal cells from multiple donors following culture expansion. [Stem Cells] Abstract

Potential of VEGF-Encapsulated Electrospun Nanofibers for In Vitro Cardiomyogenic Differentiation of Human Mesenchymal Stem Cells
Researchers investigated the potential of human mesenchymal stem cells to differentiate into cardiomyogenic cell lineages, using 5-azacytidine on electrospun poly(ε-caprolactone)-gelatin nanofibrous scaffolds. [J Tissue Eng Regen Med] Abstract

Oxidation of the Aromatic Amino Acids Tryptophan and Tyrosine Disrupts Their Anabolic Effects on Bone Marrow Mesenchymal Stem Cells
Using mouse bone marrow mesenchymal stem cells, scientists examined the effects of the oxidized amino acids di-tyrosine and kynurenine on proliferation, differentiation and mitogen-activated protein kinase pathway. [Mol Cell Endocrinol] Abstract

Comparison between Xenogeneic and Allogeneic Adipose Mesenchymal Stem Cells in the Treatment of Acute Cerebral Infarct: Proof of Concept in Rats
Investigators analyzed whether xenogeneic human adipose tissue-derived-mesenchymal stem cells (AD-MSCs) were as safe and effective as allogeneic rat AD-MSCs in permanent middle cerebral artery occlusion in rats. [J Transl Med] Abstract | Full Article

Lysophosphatidic Acid Rescues Bone Mesenchymal Stem Cells from Hydrogen Peroxide-Induced Apoptosis
Researchers demonstrate that lysophosphatidic acid protects bone marrow-derived mesenchymal stem cells against hypoxia and serum deprivation-induced apoptosis. [Apoptosis] Abstract

Impact of the Uremic Milieu on the Osteogenic Potential of Mesenchymal Stem Cells
To study the effects of the uremic milieu on osteogenic properties, researchers applied an in vitro assay culturing human mesenchymal stem cells in osteogenic medium supplemented with serum from healthy donors and from uremic patients on hemodialysis. [PLoS One] Full Article

Oncostatin M Regulates Osteogenic Differentiation of Murine Adipose-Derived Mesenchymal Progenitor Cells through a PKCdelta-Dependent Mechanism
Using uncommitted murine adipose tissue-derived mesenchymal progenitors, scientists examined mechanisms of oncostatin M-induced osteogenesis. [Cell Tissue Res] Abstract

Cell Fusion between Gastric Epithelial Cells and Mesenchymal Stem Cells Results in Epithelial-to-Mesenchymal Transition and Malignant Transformation
Scientists investigated the effect of cell fusion between mesenchymal stem cells and the gastric epithelial cells in tumorigenesis. Cell fusion between cord blood mesenchymal stem cells and human gastric epithelial cells was performed in vitro. [BMC Cancer] Abstract | Full Article

Donor Age and Cell Passage Affect Osteogenic Ability of Rat Bone Marrow Mesenchymal Stem Cells
Researchers cultured bone-marrow-derived mesenchymal stem cells (BMSCs) isolated from rats of various ages and evaluated their morphology, activity, and differentiation potential. Cultured BMSCs formed monolayer of fibroblast-like cells and maintained their characteristic morphology for seven to ten generations. [Cell Biochem Biophys] Abstract

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Scaffold-Based Cartilage Treatments: With or Without Cells? A Systematic Review of Preclinical and Clinical Evidence
The authors analyzed both preclinical and clinical studies on new trends to understand how the available evidence supports the use of cell sources or justifies the cell-free approach for the scaffold-based treatment of cartilage lesions. [Arthroscopy] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.
First Canadian Clinical Trial Studying Ability of Mesenchymal Stem Cells to Treat Multiple Sclerosis
The Multiple Sclerosis Society of Canada and the Multiple Sclerosis Scientific Research Foundation announced a $4.2 million grant in support of the MEsenchymal Stem cell therapy for CAnadian MS patients (MESCAMS) study. [The Multiple Sclerosis Society of Canada] Press Release

San Diego Team Wins $1.7 Million Grant from Stem Cell Agency to Develop Quality Control Methods
A team at The Scripps Research Institute has won a $1,784,000 grant from the California Institute for Regenerative Medicine. The funding will support the development of a new method for detecting DNA damage in stem cells to ensure that only the highest quality cells are used in transplantation or therapy. [The Scripps Research Institute] Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW 2015 Conference on Tissue Engineering and Regenerative Medicine
March 18-20, 2015
Suzhou, China

Visit our events page to see a complete list of events in the mesenchymal cell community.
NEW Research Associate, Mesenchymal (STEMCELL Technologies Inc.)

NEW Researcher – Stem Cell Biology, Regeneration and Apoptosis (Israel Institute of Technology)

NEW Postdoctoral Fellow – Bioinformatics and Stem Cell Biology (The University of Texas Medical School At Houston)

NEW Postdoctoral Research Fellow – Regenerative Medicine (Loma Linda University)

Scientist – Myogenic Progenitor Cell Biology (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Postdoctoral Fellow – Vascular Bioengineering (University of Pittsburgh)

Postdoctoral Research Assistant – Mesenchymal Stem Cell Epigenetics (University of Oxford)

Postdoctoral Fellow – Wnt Signaling in Development and Disease (Van Andel Research Institute)

Postdoctoral Fellowship – CNS Inflammation (Rutgers University)

Postdoctoral Position – Morphogenetic Signaling Pathways in Development and Disease (University of Rochester Medical Center)

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